Elevated serum hepatic transaminases in apical periodontitis individuals

María José Bordagaray, Elizabeth Pellegrini, Mauricio Garrido, Patricia Hernández-Ríos, Thomas Villalobos, Alejandra Fernández, Marcela Hernández

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

1 Cita (Scopus)

Resumen

Aim: Apical periodontitis (AP) is the chronic inflammation of the periradicular tissues in response to root canal infection. Whilst AP has been linked with systemic inflammation and noncommunicable diseases, its potential association with nonalcoholic fatty liver disease (NAFLD) is unknown. We aimed to evaluate the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels as surrogate markers of hepatic injury, and the systemic inflammatory burden in otherwise healthy individuals with and without AP diagnosis. Methodology: Cross-sectional study. Individuals with AP (n = 30) and healthy controls (n = 29) were recruited. The number, mean diameter (mm) and periapical index of the apical lesions of endodontic origin (ALEO) were assessed. ALT and AST levels (pg/mL) were measured through enzyme-linked immunosorbent assays. The serum levels of TNF-α, IL-4, IL-9, IL-10, IL-17A and IL-22 were evaluated by Multiplex assay. Inferential analysis was performed using t-test or Mann–Whitney tests according to data distribution and linear regression models. Data were analysed with StataV16 (p <.05). Results: ALT and AST levels were significantly higher in individuals with AP compared to controls (p <.05). Serum inflammatory biomarkers showed no significant differences between the study groups. Bivariate and multivariate analyses confirmed that AP diagnosis was independently associated with ALT and AST elevations (p <.05). Additionally, the number of ALEO positively influenced AST levels (p =.002). IL-22 on the other hand, was associated with reduced ALT levels (p =.043). Conclusion: AP is associated with higher serum hepatic transaminases ALT and AST, potentially contributing to NAFLD physiopathology in young adults.

Idioma originalInglés
Páginas (desde-hasta)1395-1403
Número de páginas9
PublicaciónInternational Endodontic Journal
Volumen57
N.º10
DOI
EstadoEn prensa - 2024

Áreas temáticas de ASJC Scopus

  • Odontología General

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