Resumen
Electrochemical and electrophoretic behavior of sodium metamizole under conditions of variable pH has been studied. Voltammetric results indicate that sodium metamizole behaves as a quasi-reversible system over the potential window considered. These studies were complemented with capillary zone electrophoresis analysis in order to know the starting composition of solutions of sodium metamizole at different pH values and buffer composition. Among degradation products, the extent of the active metabolite 4-methylaminoantipyrine was found to be media dependent as well as was the appearance of different degradation products. Consequently, the extent of the oxidation process in voltammetric studies is dependent on the composition of the starting solutions. Information obtained by cyclic voltammetry and capillary zone electrophoresis has been concordant and conclusive in that both methods can be used in a qualitative study of sodium metamizole, under the experimental conditions assayed.
| Idioma original | English |
|---|---|
| Páginas (desde-hasta) | 1572-1575 |
| Número de páginas | 4 |
| Publicación | Journal of the Chilean Chemical Society |
| Volumen | 53 |
| N.º | 3 |
| DOI | |
| Estado | Published - 1 ene 2008 |
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ASJC Scopus subject areas
- Chemistry(all)
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Electrochemical and electrophoretic study of sodium metamizole. / Basáez, Luis A.; Periĉ, Iván M.; Jara, Paola A.; Soto, César A.; Contreras, David R.; Aguirre, Carolina; Vanýsek, Petr.
En: Journal of the Chilean Chemical Society, Vol. 53, N.º 3, 01.01.2008, p. 1572-1575.Resultado de la investigación: Article
TY - JOUR
T1 - Electrochemical and electrophoretic study of sodium metamizole
AU - Basáez, Luis A.
AU - Periĉ, Iván M.
AU - Jara, Paola A.
AU - Soto, César A.
AU - Contreras, David R.
AU - Aguirre, Carolina
AU - Vanýsek, Petr
PY - 2008/1/1
Y1 - 2008/1/1
N2 - Electrochemical and electrophoretic behavior of sodium metamizole under conditions of variable pH has been studied. Voltammetric results indicate that sodium metamizole behaves as a quasi-reversible system over the potential window considered. These studies were complemented with capillary zone electrophoresis analysis in order to know the starting composition of solutions of sodium metamizole at different pH values and buffer composition. Among degradation products, the extent of the active metabolite 4-methylaminoantipyrine was found to be media dependent as well as was the appearance of different degradation products. Consequently, the extent of the oxidation process in voltammetric studies is dependent on the composition of the starting solutions. Information obtained by cyclic voltammetry and capillary zone electrophoresis has been concordant and conclusive in that both methods can be used in a qualitative study of sodium metamizole, under the experimental conditions assayed.
AB - Electrochemical and electrophoretic behavior of sodium metamizole under conditions of variable pH has been studied. Voltammetric results indicate that sodium metamizole behaves as a quasi-reversible system over the potential window considered. These studies were complemented with capillary zone electrophoresis analysis in order to know the starting composition of solutions of sodium metamizole at different pH values and buffer composition. Among degradation products, the extent of the active metabolite 4-methylaminoantipyrine was found to be media dependent as well as was the appearance of different degradation products. Consequently, the extent of the oxidation process in voltammetric studies is dependent on the composition of the starting solutions. Information obtained by cyclic voltammetry and capillary zone electrophoresis has been concordant and conclusive in that both methods can be used in a qualitative study of sodium metamizole, under the experimental conditions assayed.
KW - Capillary zone electrophoresis
KW - Drugs
KW - Electrochemical determination
KW - NSAID
KW - Sodium metamizole
KW - Voltammetry
UR - http://www.scopus.com/inward/record.url?scp=54949093543&partnerID=8YFLogxK
U2 - 10.4067/S0717-97072008000300004
DO - 10.4067/S0717-97072008000300004
M3 - Article
AN - SCOPUS:54949093543
VL - 53
SP - 1572
EP - 1575
JO - Journal of the Chilean Chemical Society
JF - Journal of the Chilean Chemical Society
SN - 0717-9324
IS - 3
ER -