TY - JOUR
T1 - Effects of prenatal stress and exercise on dentate granule cells maturation and spatial memory in adolescent mice
AU - Bustamante, Carlos
AU - Bilbao, Pamela
AU - Contreras, William
AU - Martínez, Mauricio
AU - Mendoza, Antonio
AU - Reyes, Álvaro
AU - Pascual, Rodrigo
PY - 2010/11/1
Y1 - 2010/11/1
N2 - Exposure to prenatal stress (PS) increases the risk of developing neurobehavioral disturbances later in life. Previous work has shown that exercise can exert beneficial effects on brain damage; however, it is unknown whether voluntary wheel running (VWR) can ameliorate the neurobehavioral impairments induced by PS in adolescent offspring. Pregnant CF-1 mice were randomly assigned to control (n= 5) or stressed (n= 5) groups. Pregnant dams were subjected to restraint stress between gestational days 14 and 21 (G14-21), whereas controls remained undisturbed in their home cages. On postnatal day 21 (P21), male pups were randomly assigned to the following experimental groups: control (n= 5), stressed (n= 5), and stressed mice. +. daily submitted to VWR (n= 4). At P52, all groups were behaviorally evaluated in the Morris water maze. Animals were then sacrificed, and Golgi-impregnated granule cells were morphometrically analyzed. The results indicate that PS produced significant behavioral and neuronal impairments in adolescent offspring and that VWR significantly offset these deleterious effects.
AB - Exposure to prenatal stress (PS) increases the risk of developing neurobehavioral disturbances later in life. Previous work has shown that exercise can exert beneficial effects on brain damage; however, it is unknown whether voluntary wheel running (VWR) can ameliorate the neurobehavioral impairments induced by PS in adolescent offspring. Pregnant CF-1 mice were randomly assigned to control (n= 5) or stressed (n= 5) groups. Pregnant dams were subjected to restraint stress between gestational days 14 and 21 (G14-21), whereas controls remained undisturbed in their home cages. On postnatal day 21 (P21), male pups were randomly assigned to the following experimental groups: control (n= 5), stressed (n= 5), and stressed mice. +. daily submitted to VWR (n= 4). At P52, all groups were behaviorally evaluated in the Morris water maze. Animals were then sacrificed, and Golgi-impregnated granule cells were morphometrically analyzed. The results indicate that PS produced significant behavioral and neuronal impairments in adolescent offspring and that VWR significantly offset these deleterious effects.
KW - Dentate granule cells
KW - Morris water maze
KW - Prenatal stress
KW - Voluntary wheel running
UR - http://www.scopus.com/inward/record.url?scp=79961143085&partnerID=8YFLogxK
U2 - 10.1016/j.ijdevneu.2010.07.229
DO - 10.1016/j.ijdevneu.2010.07.229
M3 - Article
C2 - 20638465
AN - SCOPUS:79961143085
SN - 0736-5748
VL - 28
SP - 605
EP - 609
JO - International Journal of Developmental Neuroscience
JF - International Journal of Developmental Neuroscience
IS - 7
ER -