EFFECTS OF OXYPERTINE ON THE ISOLATED VAS DEFERENS OF THE RAT

H. MIRANDA

doi:10.1111/j.1476-5381.1978.tb07755.x

EFFECTS OF OXYPERTINE ON THE ISOLATED VAS DEFERENS OF THE RAT

H. MIRANDA

Facultad Medicina

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

4 Citas (Scopus)

Resumen

The isolated vas deferens of the rat was used to examine the peripheral action of oxypertine, a psychotropic‐anxiolytic drug. Oxypertine (4.4 × 10⁻¹⁰m to 2.6 × 10⁻⁵m) antagonized competitively the effects of noradrenaline (pA₂ = 7.2), 5‐hydroxytryptamine (pA₂ = 8.6) and dopamine (pA₂ = 9.8). Oxypertine (8.8 × 10 ⁻⁹m to 2.6 × 10⁻⁵m) antagonized the effects of low concentrations of acetylcholine and enhanced the contractions elicited by high concentrations of acetylcholine. The contractions evoked by transmural stimulation of the vas deferens were reduced by oxypertine. Oxypertine failed to antagonize the responses to potassium chloride. These findings are compared with the effects of other antidepressant drugs. 1978 British Pharmacological Society

Idioma original	Inglés
Páginas (desde-hasta)	515-518
Número de páginas	4
Publicación	British Journal of Pharmacology
Volumen	62
N.º	4
DOI	https://doi.org/10.1111/j.1476-5381.1978.tb07755.x
Estado	Publicada - abr. 1978

Áreas temáticas de ASJC Scopus

Farmacología

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title = "EFFECTS OF OXYPERTINE ON THE ISOLATED VAS DEFERENS OF THE RAT",

abstract = "The isolated vas deferens of the rat was used to examine the peripheral action of oxypertine, a psychotropic‐anxiolytic drug. Oxypertine (4.4 × 10−10m to 2.6 × 10−5m) antagonized competitively the effects of noradrenaline (pA2 = 7.2), 5‐hydroxytryptamine (pA2 = 8.6) and dopamine (pA2 = 9.8). Oxypertine (8.8 × 10 −9m to 2.6 × 10−5m) antagonized the effects of low concentrations of acetylcholine and enhanced the contractions elicited by high concentrations of acetylcholine. The contractions evoked by transmural stimulation of the vas deferens were reduced by oxypertine. Oxypertine failed to antagonize the responses to potassium chloride. These findings are compared with the effects of other antidepressant drugs. 1978 British Pharmacological Society",

author = "H. MIRANDA",

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AB - The isolated vas deferens of the rat was used to examine the peripheral action of oxypertine, a psychotropic‐anxiolytic drug. Oxypertine (4.4 × 10−10m to 2.6 × 10−5m) antagonized competitively the effects of noradrenaline (pA2 = 7.2), 5‐hydroxytryptamine (pA2 = 8.6) and dopamine (pA2 = 9.8). Oxypertine (8.8 × 10 −9m to 2.6 × 10−5m) antagonized the effects of low concentrations of acetylcholine and enhanced the contractions elicited by high concentrations of acetylcholine. The contractions evoked by transmural stimulation of the vas deferens were reduced by oxypertine. Oxypertine failed to antagonize the responses to potassium chloride. These findings are compared with the effects of other antidepressant drugs. 1978 British Pharmacological Society

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EFFECTS OF OXYPERTINE ON THE ISOLATED VAS DEFERENS OF THE RAT

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