EFFECTS OF OXYPERTINE ON THE ISOLATED VAS DEFERENS OF THE RAT

H. MIRANDA

Resultado de la investigación: Contribución a una revistaArtículo

4 Citas (Scopus)

Resumen

The isolated vas deferens of the rat was used to examine the peripheral action of oxypertine, a psychotropic‐anxiolytic drug. Oxypertine (4.4 × 10−10m to 2.6 × 10−5m) antagonized competitively the effects of noradrenaline (pA2 = 7.2), 5‐hydroxytryptamine (pA2 = 8.6) and dopamine (pA2 = 9.8). Oxypertine (8.8 × 10 −9m to 2.6 × 10−5m) antagonized the effects of low concentrations of acetylcholine and enhanced the contractions elicited by high concentrations of acetylcholine. The contractions evoked by transmural stimulation of the vas deferens were reduced by oxypertine. Oxypertine failed to antagonize the responses to potassium chloride. These findings are compared with the effects of other antidepressant drugs. 1978 British Pharmacological Society

Idioma originalInglés
Páginas (desde-hasta)515-518
Número de páginas4
PublicaciónBritish Journal of Pharmacology
Volumen62
N.º4
DOI
EstadoPublicada - 1 ene 1978

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