Effects of multidisciplinary therapy on physical function in Huntington's disease

Travis M. Cruickshank, Alvaro P. Reyes, Luis E. Penailillo, Tim Pulverenti, Danielle M. Bartlett, Pauline Zaenker, Anthony J. Blazevich, Robert U. Newton, Jennifer A. Thompson, Johnny Lo, Mel R. Ziman

Resultado de la investigación: Article

4 Citas (Scopus)

Resumen

Objective: The primary objective of this trial was to evaluate the effects of outpatient multidisciplinary therapy, compared to usual care, on measures of physical function and muscle strength in patients with manifest Huntington's disease (HD). Methods: Twenty-two patients with clinically verified HD were randomized to receive 36 weeks of outpatient multidisciplinary therapy or usual care. Outpatient multidisciplinary therapy comprised 9 months of supervised exercise, cognitive therapy and self-directed home-based exercise. Usual care consisted of standard medical care. Patients were assessed at 0 and 36 weeks by blinded assessors. The primary outcome was changed in mobility as measured by the 10-m Timed Walk Test. Secondary outcome measures included changes in manual dexterity (Timed Nut and Bolt Test), balance (Berg Balance Scale), cardiorespiratory endurance (6-Minute Walk Test) and upper and lower extremity muscle strength (isokinetic and isometric muscle strength and 10 Repetition Sit-to-Stand Tests). Results: Patients receiving outpatient multidisciplinary therapy demonstrated significantly enhanced manual dexterity (P < 0.05) and lower extremity muscle strength (P < 0.05) than patients receiving usual care. No significant differences in mobility, balance, cardiorespiratory endurance and upper extremity strength outcomes were observed between groups after the intervention period. There were no adverse events associated with multidisciplinary therapy. Conclusion: Our findings suggest that outpatient multidisciplinary therapy has positive effects on manual dexterity and muscle strength, but no meaningful effects on mobility, balance, cardiorespiratory endurance and upper extremity muscle strength in patients with HD. Larger randomized controlled trials are needed to confirm these preliminary findings.

Idioma originalEnglish
PublicaciónActa Neurologica Scandinavica
DOI
EstadoAccepted/In press - 1 ene 2018

Huella dactilar

Huntington Disease
Muscle Strength
Outpatients
Upper Extremity
Lower Extremity
Therapeutics
Exercise Therapy
Cognitive Therapy
Standard of Care
Randomized Controlled Trials
Outcome Assessment (Health Care)
Exercise

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Citar esto

Cruickshank, T. M., Reyes, A. P., Penailillo, L. E., Pulverenti, T., Bartlett, D. M., Zaenker, P., ... Ziman, M. R. (Aceptado/En prensa). Effects of multidisciplinary therapy on physical function in Huntington's disease. Acta Neurologica Scandinavica. https://doi.org/10.1111/ane.13002
Cruickshank, Travis M. ; Reyes, Alvaro P. ; Penailillo, Luis E. ; Pulverenti, Tim ; Bartlett, Danielle M. ; Zaenker, Pauline ; Blazevich, Anthony J. ; Newton, Robert U. ; Thompson, Jennifer A. ; Lo, Johnny ; Ziman, Mel R. / Effects of multidisciplinary therapy on physical function in Huntington's disease. En: Acta Neurologica Scandinavica. 2018.
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abstract = "Objective: The primary objective of this trial was to evaluate the effects of outpatient multidisciplinary therapy, compared to usual care, on measures of physical function and muscle strength in patients with manifest Huntington's disease (HD). Methods: Twenty-two patients with clinically verified HD were randomized to receive 36 weeks of outpatient multidisciplinary therapy or usual care. Outpatient multidisciplinary therapy comprised 9 months of supervised exercise, cognitive therapy and self-directed home-based exercise. Usual care consisted of standard medical care. Patients were assessed at 0 and 36 weeks by blinded assessors. The primary outcome was changed in mobility as measured by the 10-m Timed Walk Test. Secondary outcome measures included changes in manual dexterity (Timed Nut and Bolt Test), balance (Berg Balance Scale), cardiorespiratory endurance (6-Minute Walk Test) and upper and lower extremity muscle strength (isokinetic and isometric muscle strength and 10 Repetition Sit-to-Stand Tests). Results: Patients receiving outpatient multidisciplinary therapy demonstrated significantly enhanced manual dexterity (P < 0.05) and lower extremity muscle strength (P < 0.05) than patients receiving usual care. No significant differences in mobility, balance, cardiorespiratory endurance and upper extremity strength outcomes were observed between groups after the intervention period. There were no adverse events associated with multidisciplinary therapy. Conclusion: Our findings suggest that outpatient multidisciplinary therapy has positive effects on manual dexterity and muscle strength, but no meaningful effects on mobility, balance, cardiorespiratory endurance and upper extremity muscle strength in patients with HD. Larger randomized controlled trials are needed to confirm these preliminary findings.",
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Cruickshank, TM, Reyes, AP, Penailillo, LE, Pulverenti, T, Bartlett, DM, Zaenker, P, Blazevich, AJ, Newton, RU, Thompson, JA, Lo, J & Ziman, MR 2018, 'Effects of multidisciplinary therapy on physical function in Huntington's disease', Acta Neurologica Scandinavica. https://doi.org/10.1111/ane.13002

Effects of multidisciplinary therapy on physical function in Huntington's disease. / Cruickshank, Travis M.; Reyes, Alvaro P.; Penailillo, Luis E.; Pulverenti, Tim; Bartlett, Danielle M.; Zaenker, Pauline; Blazevich, Anthony J.; Newton, Robert U.; Thompson, Jennifer A.; Lo, Johnny; Ziman, Mel R.

En: Acta Neurologica Scandinavica, 01.01.2018.

Resultado de la investigación: Article

TY - JOUR

T1 - Effects of multidisciplinary therapy on physical function in Huntington's disease

AU - Cruickshank, Travis M.

AU - Reyes, Alvaro P.

AU - Penailillo, Luis E.

AU - Pulverenti, Tim

AU - Bartlett, Danielle M.

AU - Zaenker, Pauline

AU - Blazevich, Anthony J.

AU - Newton, Robert U.

AU - Thompson, Jennifer A.

AU - Lo, Johnny

AU - Ziman, Mel R.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objective: The primary objective of this trial was to evaluate the effects of outpatient multidisciplinary therapy, compared to usual care, on measures of physical function and muscle strength in patients with manifest Huntington's disease (HD). Methods: Twenty-two patients with clinically verified HD were randomized to receive 36 weeks of outpatient multidisciplinary therapy or usual care. Outpatient multidisciplinary therapy comprised 9 months of supervised exercise, cognitive therapy and self-directed home-based exercise. Usual care consisted of standard medical care. Patients were assessed at 0 and 36 weeks by blinded assessors. The primary outcome was changed in mobility as measured by the 10-m Timed Walk Test. Secondary outcome measures included changes in manual dexterity (Timed Nut and Bolt Test), balance (Berg Balance Scale), cardiorespiratory endurance (6-Minute Walk Test) and upper and lower extremity muscle strength (isokinetic and isometric muscle strength and 10 Repetition Sit-to-Stand Tests). Results: Patients receiving outpatient multidisciplinary therapy demonstrated significantly enhanced manual dexterity (P < 0.05) and lower extremity muscle strength (P < 0.05) than patients receiving usual care. No significant differences in mobility, balance, cardiorespiratory endurance and upper extremity strength outcomes were observed between groups after the intervention period. There were no adverse events associated with multidisciplinary therapy. Conclusion: Our findings suggest that outpatient multidisciplinary therapy has positive effects on manual dexterity and muscle strength, but no meaningful effects on mobility, balance, cardiorespiratory endurance and upper extremity muscle strength in patients with HD. Larger randomized controlled trials are needed to confirm these preliminary findings.

AB - Objective: The primary objective of this trial was to evaluate the effects of outpatient multidisciplinary therapy, compared to usual care, on measures of physical function and muscle strength in patients with manifest Huntington's disease (HD). Methods: Twenty-two patients with clinically verified HD were randomized to receive 36 weeks of outpatient multidisciplinary therapy or usual care. Outpatient multidisciplinary therapy comprised 9 months of supervised exercise, cognitive therapy and self-directed home-based exercise. Usual care consisted of standard medical care. Patients were assessed at 0 and 36 weeks by blinded assessors. The primary outcome was changed in mobility as measured by the 10-m Timed Walk Test. Secondary outcome measures included changes in manual dexterity (Timed Nut and Bolt Test), balance (Berg Balance Scale), cardiorespiratory endurance (6-Minute Walk Test) and upper and lower extremity muscle strength (isokinetic and isometric muscle strength and 10 Repetition Sit-to-Stand Tests). Results: Patients receiving outpatient multidisciplinary therapy demonstrated significantly enhanced manual dexterity (P < 0.05) and lower extremity muscle strength (P < 0.05) than patients receiving usual care. No significant differences in mobility, balance, cardiorespiratory endurance and upper extremity strength outcomes were observed between groups after the intervention period. There were no adverse events associated with multidisciplinary therapy. Conclusion: Our findings suggest that outpatient multidisciplinary therapy has positive effects on manual dexterity and muscle strength, but no meaningful effects on mobility, balance, cardiorespiratory endurance and upper extremity muscle strength in patients with HD. Larger randomized controlled trials are needed to confirm these preliminary findings.

KW - Balance

KW - Huntington's disease

KW - Manual dexterity

KW - Mobility

KW - Muscle strength

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DO - 10.1111/ane.13002

M3 - Article

AN - SCOPUS:85051144128

JO - Acta Neurologica Scandinavica

JF - Acta Neurologica Scandinavica

SN - 0001-6314

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