Effects of clonixin, a non-steroidal analgesic, on the neurotransmission of the vas deferens of the rat

D. Bustamante, H. F. Miranda, C. Paeile, W. W. Wolstenholme

Resultado de la investigación: Article

6 Citas (Scopus)

Resumen

1. 1. The effect of C1X on the responses to TNS, ACh and NE in the isolated rat vas deferens was studied. 2. 2. C1X produced a significant reduction of muscular twitch induced by TNS. 3. 3. The M1-ACh response was significantly increased by this non-steroidal analgesic. 4. 4. The M2-ACh response was not changed by pre-treatment with C1X. 5. 5. The α1-NE response was not altered by C1X. 6. 6. The α2-NE response was potentiated by pre-treatment with C1X. 7. 7. The findings suggest that C1X beside its ability to block the release of NE, has some common pharmacological properties, close to those of a "calcium modulator".

Idioma originalEnglish
Páginas (desde-hasta)755-758
Número de páginas4
PublicaciónGeneral Pharmacology
Volumen19
N.º6
EstadoPublished - 1988

Huella dactilar

Clonixin
Vas Deferens
Synaptic Transmission
Analgesics
Pharmacology
Calcium
2-(4-toluidino)-6-naphthalenesulfonic acid

ASJC Scopus subject areas

  • Pharmacology

Citar esto

Bustamante, D., Miranda, H. F., Paeile, C., & Wolstenholme, W. W. (1988). Effects of clonixin, a non-steroidal analgesic, on the neurotransmission of the vas deferens of the rat. General Pharmacology, 19(6), 755-758.
Bustamante, D. ; Miranda, H. F. ; Paeile, C. ; Wolstenholme, W. W. / Effects of clonixin, a non-steroidal analgesic, on the neurotransmission of the vas deferens of the rat. En: General Pharmacology. 1988 ; Vol. 19, N.º 6. pp. 755-758.
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abstract = "1. 1. The effect of C1X on the responses to TNS, ACh and NE in the isolated rat vas deferens was studied. 2. 2. C1X produced a significant reduction of muscular twitch induced by TNS. 3. 3. The M1-ACh response was significantly increased by this non-steroidal analgesic. 4. 4. The M2-ACh response was not changed by pre-treatment with C1X. 5. 5. The α1-NE response was not altered by C1X. 6. 6. The α2-NE response was potentiated by pre-treatment with C1X. 7. 7. The findings suggest that C1X beside its ability to block the release of NE, has some common pharmacological properties, close to those of a {"}calcium modulator{"}.",
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Bustamante, D, Miranda, HF, Paeile, C & Wolstenholme, WW 1988, 'Effects of clonixin, a non-steroidal analgesic, on the neurotransmission of the vas deferens of the rat', General Pharmacology, vol. 19, n.º 6, pp. 755-758.

Effects of clonixin, a non-steroidal analgesic, on the neurotransmission of the vas deferens of the rat. / Bustamante, D.; Miranda, H. F.; Paeile, C.; Wolstenholme, W. W.

En: General Pharmacology, Vol. 19, N.º 6, 1988, p. 755-758.

Resultado de la investigación: Article

TY - JOUR

T1 - Effects of clonixin, a non-steroidal analgesic, on the neurotransmission of the vas deferens of the rat

AU - Bustamante, D.

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AU - Paeile, C.

AU - Wolstenholme, W. W.

PY - 1988

Y1 - 1988

N2 - 1. 1. The effect of C1X on the responses to TNS, ACh and NE in the isolated rat vas deferens was studied. 2. 2. C1X produced a significant reduction of muscular twitch induced by TNS. 3. 3. The M1-ACh response was significantly increased by this non-steroidal analgesic. 4. 4. The M2-ACh response was not changed by pre-treatment with C1X. 5. 5. The α1-NE response was not altered by C1X. 6. 6. The α2-NE response was potentiated by pre-treatment with C1X. 7. 7. The findings suggest that C1X beside its ability to block the release of NE, has some common pharmacological properties, close to those of a "calcium modulator".

AB - 1. 1. The effect of C1X on the responses to TNS, ACh and NE in the isolated rat vas deferens was studied. 2. 2. C1X produced a significant reduction of muscular twitch induced by TNS. 3. 3. The M1-ACh response was significantly increased by this non-steroidal analgesic. 4. 4. The M2-ACh response was not changed by pre-treatment with C1X. 5. 5. The α1-NE response was not altered by C1X. 6. 6. The α2-NE response was potentiated by pre-treatment with C1X. 7. 7. The findings suggest that C1X beside its ability to block the release of NE, has some common pharmacological properties, close to those of a "calcium modulator".

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