Effects of clonixin, a non-steroidal analgesic, on the neurotransmission of the vas deferens of the rat

D. Bustamante, H. F. Miranda, C. Paeile, W. W. Wolstenholme

Resultado de la investigación: Contribución a una revistaArtículo

6 Citas (Scopus)

Resumen

1. 1. The effect of C1X on the responses to TNS, ACh and NE in the isolated rat vas deferens was studied. 2. 2. C1X produced a significant reduction of muscular twitch induced by TNS. 3. 3. The M1-ACh response was significantly increased by this non-steroidal analgesic. 4. 4. The M2-ACh response was not changed by pre-treatment with C1X. 5. 5. The α1-NE response was not altered by C1X. 6. 6. The α2-NE response was potentiated by pre-treatment with C1X. 7. 7. The findings suggest that C1X beside its ability to block the release of NE, has some common pharmacological properties, close to those of a "calcium modulator".

Idioma originalInglés
Páginas (desde-hasta)755-758
Número de páginas4
PublicaciónGeneral Pharmacology
Volumen19
N.º6
EstadoPublicada - 1988

Áreas temáticas de ASJC Scopus

  • Farmacología

Huella Profundice en los temas de investigación de 'Effects of clonixin, a non-steroidal analgesic, on the neurotransmission of the vas deferens of the rat'. En conjunto forman una huella única.

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    Bustamante, D., Miranda, H. F., Paeile, C., & Wolstenholme, W. W. (1988). Effects of clonixin, a non-steroidal analgesic, on the neurotransmission of the vas deferens of the rat. General Pharmacology, 19(6), 755-758.