TY - JOUR
T1 - Effects of Capsaicin and Capsiate on Endurance Performance
T2 - A Meta-Analysis
AU - Grgic, Jozo
AU - Memon, Aamir Raoof
AU - Chen, Sitong
AU - Ramirez-Campillo, Rodrigo
AU - Barreto, Gabriel
AU - Haugen, Markus Estifanos
AU - Schoenfeld, Brad J.
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/11
Y1 - 2022/11
N2 - Several studies have explored the effects of capsaicin and capsiate on endurance performance, with conflicting findings. This systematic review aimed to perform a meta-analysis examining the effects of capsaicin and capsiate vs. placebo on endurance performance in humans. Seven databases were searched to find eligible studies. The effects of capsaicin and capsiate on aerobic endurance (e.g., time-trials or time-to-exhaustion tests), muscular endurance (e.g., repetitions performed to muscular failure), and rating of perceived exertion (RPE) were examined in a random-effects meta-analysis. Fourteen studies (n = 183) were included in the review. Most studies provided capsaicin or capsiate in the dose of 12 mg, 45 min before exercise. In the meta-analysis for aerobic endurance, there was no significant difference between the placebo and capsaicin/capsiate conditions (Cohen’s d: 0.04; 95% confidence interval: −0.16, 0.25; p = 0.69). In subgroup meta-analyses, there were no significant differences between the placebo and capsaicin/capsiate conditions when analyzing only studies that used time-trials (p = 0.20) or time-to-exhaustion tests (p = 0.80). In the meta-analysis for muscular endurance, a significant ergogenic effect of capsaicin/capsiate was found (Cohen’s d: 0.27; 95% confidence interval: 0.10, 0.43; p = 0.002). When analyzing set-specific effects, an ergogenic effect of capsaicin/capsiate was found in set 1, set 2, and set 3 (Cohen’s d: 0.21–29). Capsaicin/capsiate ingestion reduced RPE following muscular endurance (p = 0.03) but not aerobic endurance tests (p = 0.58). In summary, capsaicin/capsiate supplementation acutely enhances muscular endurance, while the effects on aerobic endurance are less clear.
AB - Several studies have explored the effects of capsaicin and capsiate on endurance performance, with conflicting findings. This systematic review aimed to perform a meta-analysis examining the effects of capsaicin and capsiate vs. placebo on endurance performance in humans. Seven databases were searched to find eligible studies. The effects of capsaicin and capsiate on aerobic endurance (e.g., time-trials or time-to-exhaustion tests), muscular endurance (e.g., repetitions performed to muscular failure), and rating of perceived exertion (RPE) were examined in a random-effects meta-analysis. Fourteen studies (n = 183) were included in the review. Most studies provided capsaicin or capsiate in the dose of 12 mg, 45 min before exercise. In the meta-analysis for aerobic endurance, there was no significant difference between the placebo and capsaicin/capsiate conditions (Cohen’s d: 0.04; 95% confidence interval: −0.16, 0.25; p = 0.69). In subgroup meta-analyses, there were no significant differences between the placebo and capsaicin/capsiate conditions when analyzing only studies that used time-trials (p = 0.20) or time-to-exhaustion tests (p = 0.80). In the meta-analysis for muscular endurance, a significant ergogenic effect of capsaicin/capsiate was found (Cohen’s d: 0.27; 95% confidence interval: 0.10, 0.43; p = 0.002). When analyzing set-specific effects, an ergogenic effect of capsaicin/capsiate was found in set 1, set 2, and set 3 (Cohen’s d: 0.21–29). Capsaicin/capsiate ingestion reduced RPE following muscular endurance (p = 0.03) but not aerobic endurance tests (p = 0.58). In summary, capsaicin/capsiate supplementation acutely enhances muscular endurance, while the effects on aerobic endurance are less clear.
KW - dietary supplement
KW - performance-enhancing substances
KW - resistance training
UR - http://www.scopus.com/inward/record.url?scp=85141649534&partnerID=8YFLogxK
U2 - 10.3390/nu14214531
DO - 10.3390/nu14214531
M3 - Review article
C2 - 36364793
AN - SCOPUS:85141649534
VL - 14
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 21
M1 - 4531
ER -