Effects of a dairy product fortified with multiple micronutrients and omega-3 fatty acids on birth weight and gestation duration in pregnant Chilean women

Francisco Mardones, Maria Teresa Urrutia, Luis Villarroel, Alonso Rioseco, Oscar Castillo, Jaime Rozowski, Jose Luis Tapia, Gabriel Bastias, Jorge Bacallao, Ivan Rojas

Resultado de la investigación: Contribución a una revistaArtículo

43 Citas (Scopus)

Resumen

Objective: To test the hypothesis that maternal food fortification with omega-3 fatty acids and multiple micronutrients increases birth weight and gestation duration, as primary outcomes. Design: Non-blinded, randomised controlled study. Setting: Pregnant women received powdered milk during their health check-ups at 19 antenatal clinics and delivered at two maternity hospitals in Santiago, Chile. Subject: Pregnant women were assigned to receive regular powdered milk (n = 477) or a milk product fortified with multiple micronutrients and omega-3 fatty acids (n = 495). Results: Intention-to-treat analysis showed that mean birth weight was higher in the intervention group than in controls (65.4 g difference, 95% confidence interval (CI) 5-126 g; P = 0.03) and the incidence of very preterm birth (<34 weeks) was lower (0.4% vs. 2.1%; P = 0.03). On-treatment analysis showed a mean birth weight difference of 118 g (95% CI 47-190 g; P = 0.001) and a relative fall in both the proportion of birth weight ≤3000 g (P = 0.015) and the incidence of pre-eclampsia (P = 0.015). Compliance with the experimental product was apparent from a haematological study of red-blood-cell folate at the end of pregnancy, which was performed in a sub-sample. In both types of analyses, positive differences were also present for mean gestation duration, birth length and head circumference. Nevertheless, the relatively small sample sizes allowed a statistical power of >0.80 just for mean birth weight and birth length in the on-treatment analysis; birth length in that analysis had a difference of 0.57 cm (95% CI 0.19-0.96 cm; P = 0.003). Conclusions: The new intervention resulted in increased mean birth weight. Associations with gestation duration and most secondary outcomes need a larger sample size for confirmation.

Idioma originalInglés
Páginas (desde-hasta)30-40
Número de páginas11
PublicaciónPublic Health Nutrition
Volumen11
N.º1
DOI
EstadoPublicada - 1 ene 2008

Áreas temáticas de ASJC Scopus

  • Medicina (miscelánea)
  • Nutrición y dietética
  • Salud pública, medioambiental y laboral

Huella Profundice en los temas de investigación de 'Effects of a dairy product fortified with multiple micronutrients and omega-3 fatty acids on birth weight and gestation duration in pregnant Chilean women'. En conjunto forman una huella única.

  • Citar esto