Effect of the antiprogestin onapristone on follicular growth in women

Horacio B. Croxatto, Ana M. Salvatierra, Blanca Fuentealba, Christian Zurth, Sybille Beier

Resultado de la investigación: Article

18 Citas (Scopus)

Resumen

The effects of the antiprogestion onapristone on the menstrual cycle were assessed in surgically sterilized volunteer women. The steroid was given orally at the dose of 5, 15 or 50 mg/day, from day 5 to day 11 of the cycle. Ovarian ultrasonography and hormonal determinations in plasma and urine were used to monitor the pre-treatment, treated and post-treatment cycles. Onapristone, given at a dose of 5 mg/day, arrested follicular growth and inconsistently. The dose of 15 or 50 mg/day arrested follicular growth and oestradiol increase and delayed gonadotrophin surge, extending the length of the follicular phase in five of seven women in each group. After discontinuation of treatment the leading follicle resumed its growth and ovulation occurred as judged by the elevation of plasma progesterone, preceded in most but not all cases by an echographic image of follicular collapse. The ensuing luteal phases were not significantly altered in length or plasma progesterone concentration. Cortisol concentrations were unaffected and no serious side-effects were recorded. The antifolliculotrophic effect of onapristone demonstrated here, together with previous reports of similar activity of mifepristone in women, indicate that this may be a general property of compounds that interfere with progesterone receptor function.

Idioma originalEnglish
Páginas (desde-hasta)1442-1447
Número de páginas6
PublicaciónHuman Reproduction
Volumen9
N.º8
DOI
EstadoPublished - 1 ene 1994

Huella dactilar

Progesterone
Growth
Mifepristone
Follicular Phase
Luteal Phase
Progesterone Receptors
Menstrual Cycle
Ovulation
Gonadotropins
Hydrocortisone
Volunteers
Estradiol
Ultrasonography
Therapeutics
Steroids
Urine
onapristone

ASJC Scopus subject areas

  • Reproductive Medicine
  • Rehabilitation
  • Obstetrics and Gynaecology

Citar esto

Croxatto, Horacio B. ; Salvatierra, Ana M. ; Fuentealba, Blanca ; Zurth, Christian ; Beier, Sybille. / Effect of the antiprogestin onapristone on follicular growth in women. En: Human Reproduction. 1994 ; Vol. 9, N.º 8. pp. 1442-1447.
@article{cd13d77c689247d8bb451bf2e236445d,
title = "Effect of the antiprogestin onapristone on follicular growth in women",
abstract = "The effects of the antiprogestion onapristone on the menstrual cycle were assessed in surgically sterilized volunteer women. The steroid was given orally at the dose of 5, 15 or 50 mg/day, from day 5 to day 11 of the cycle. Ovarian ultrasonography and hormonal determinations in plasma and urine were used to monitor the pre-treatment, treated and post-treatment cycles. Onapristone, given at a dose of 5 mg/day, arrested follicular growth and inconsistently. The dose of 15 or 50 mg/day arrested follicular growth and oestradiol increase and delayed gonadotrophin surge, extending the length of the follicular phase in five of seven women in each group. After discontinuation of treatment the leading follicle resumed its growth and ovulation occurred as judged by the elevation of plasma progesterone, preceded in most but not all cases by an echographic image of follicular collapse. The ensuing luteal phases were not significantly altered in length or plasma progesterone concentration. Cortisol concentrations were unaffected and no serious side-effects were recorded. The antifolliculotrophic effect of onapristone demonstrated here, together with previous reports of similar activity of mifepristone in women, indicate that this may be a general property of compounds that interfere with progesterone receptor function.",
keywords = "Antiprogestin, Follicular maturation, Human, Onapristone, RU486",
author = "Croxatto, {Horacio B.} and Salvatierra, {Ana M.} and Blanca Fuentealba and Christian Zurth and Sybille Beier",
year = "1994",
month = "1",
day = "1",
doi = "10.1093/oxfordjournals.humrep.a138726",
language = "English",
volume = "9",
pages = "1442--1447",
journal = "Human Reproduction",
issn = "0268-1161",
publisher = "Oxford University Press",
number = "8",

}

Effect of the antiprogestin onapristone on follicular growth in women. / Croxatto, Horacio B.; Salvatierra, Ana M.; Fuentealba, Blanca; Zurth, Christian; Beier, Sybille.

En: Human Reproduction, Vol. 9, N.º 8, 01.01.1994, p. 1442-1447.

Resultado de la investigación: Article

TY - JOUR

T1 - Effect of the antiprogestin onapristone on follicular growth in women

AU - Croxatto, Horacio B.

AU - Salvatierra, Ana M.

AU - Fuentealba, Blanca

AU - Zurth, Christian

AU - Beier, Sybille

PY - 1994/1/1

Y1 - 1994/1/1

N2 - The effects of the antiprogestion onapristone on the menstrual cycle were assessed in surgically sterilized volunteer women. The steroid was given orally at the dose of 5, 15 or 50 mg/day, from day 5 to day 11 of the cycle. Ovarian ultrasonography and hormonal determinations in plasma and urine were used to monitor the pre-treatment, treated and post-treatment cycles. Onapristone, given at a dose of 5 mg/day, arrested follicular growth and inconsistently. The dose of 15 or 50 mg/day arrested follicular growth and oestradiol increase and delayed gonadotrophin surge, extending the length of the follicular phase in five of seven women in each group. After discontinuation of treatment the leading follicle resumed its growth and ovulation occurred as judged by the elevation of plasma progesterone, preceded in most but not all cases by an echographic image of follicular collapse. The ensuing luteal phases were not significantly altered in length or plasma progesterone concentration. Cortisol concentrations were unaffected and no serious side-effects were recorded. The antifolliculotrophic effect of onapristone demonstrated here, together with previous reports of similar activity of mifepristone in women, indicate that this may be a general property of compounds that interfere with progesterone receptor function.

AB - The effects of the antiprogestion onapristone on the menstrual cycle were assessed in surgically sterilized volunteer women. The steroid was given orally at the dose of 5, 15 or 50 mg/day, from day 5 to day 11 of the cycle. Ovarian ultrasonography and hormonal determinations in plasma and urine were used to monitor the pre-treatment, treated and post-treatment cycles. Onapristone, given at a dose of 5 mg/day, arrested follicular growth and inconsistently. The dose of 15 or 50 mg/day arrested follicular growth and oestradiol increase and delayed gonadotrophin surge, extending the length of the follicular phase in five of seven women in each group. After discontinuation of treatment the leading follicle resumed its growth and ovulation occurred as judged by the elevation of plasma progesterone, preceded in most but not all cases by an echographic image of follicular collapse. The ensuing luteal phases were not significantly altered in length or plasma progesterone concentration. Cortisol concentrations were unaffected and no serious side-effects were recorded. The antifolliculotrophic effect of onapristone demonstrated here, together with previous reports of similar activity of mifepristone in women, indicate that this may be a general property of compounds that interfere with progesterone receptor function.

KW - Antiprogestin

KW - Follicular maturation

KW - Human

KW - Onapristone

KW - RU486

UR - http://www.scopus.com/inward/record.url?scp=0028124826&partnerID=8YFLogxK

U2 - 10.1093/oxfordjournals.humrep.a138726

DO - 10.1093/oxfordjournals.humrep.a138726

M3 - Article

C2 - 7989502

AN - SCOPUS:0028124826

VL - 9

SP - 1442

EP - 1447

JO - Human Reproduction

JF - Human Reproduction

SN - 0268-1161

IS - 8

ER -