EFFECT OF PERIODONTAL DEBRIDEMENT PLUS SYSTEMIC AZITHROMYCIN IN SUBJECTS WITH STAGE III PERIODONTITIS: A RANDOMIZED CONTROLLED CLINICAL TRIAL.

Mariely Navarrete; Héctor Oñate; Katarina Loyola; Pamela Olivares

doi:10.17126/joralres.2022.051

EFFECT OF PERIODONTAL DEBRIDEMENT PLUS SYSTEMIC AZITHROMYCIN IN SUBJECTS WITH STAGE III PERIODONTITIS: A RANDOMIZED CONTROLLED CLINICAL TRIAL.

Título traducido de la contribución: Efecto del desbridamiento periodontal más azitromicina sistémica en sujetos con periodontitis estadio III: Un ensayo clínico controlado aleatorio.

Mariely Navarrete
, Héctor Oñate
, Katarina Loyola
, Pamela Olivares

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

2 Citas (Scopus)

Resumen

Objetivo: Evaluar el efecto de la administración sistémica de azitromicina (AZM) como coadyuvante de la terapia periodontal no quirúrgica (TPNQ) en las variables clínicas y microbiológicas de pacientes con periodontitis.
Material y Métodos: Dieciocho voluntarios recibieron TPNQ combinado con placebo o AZM (500 mg/día) durante 3 días (n=9/grupo). Fueron monitoreados clínicamente para determinar Profundidad de Sondaje del Saco (PSS), Nivel de Inserción Clínica (NIC), Indice de O'Leary (IO), Sangrado al sondaje (SS) al inicio y durante el primer, tercer y sexto mes y microbiológicamente, al inicio y a los 3 y 6 meses después de la terapia, mediante la reacción en cadena de la polimerasa convencional.
Resultados: Catorce pacientes completaron el estudio (n=7/grupo). Se observaron diferencias estadísticamente significativas entre ambos grupos. El grupo experimental presentó una media de PSS significativamente menor (p=0,04)
y una reducción de PSS (p=0,02), a los 6 meses post TPNQ. En cuanto al delta (∆) pre y post tratamiento, al tercer mes post TPNQ, hubo un aumento significativo en el número de sitios poco profundos (pConclusión: AZM como adyuvante a TPNQ proporciona efectos benéficos adicionales en la PSS y SS en comparación a TPNQ solo.

Título traducido de la contribución	Efecto del desbridamiento periodontal más azitromicina sistémica en sujetos con periodontitis estadio III: Un ensayo clínico controlado aleatorio.
Idioma original	Inglés
Páginas (desde-hasta)	1-16
Número de páginas	16
Publicación	Journal of Oral Research
Volumen	11
N.º	5
DOI	https://doi.org/10.17126/joralres.2022.051
Estado	Publicada - 1 sep. 2022

Palabras clave

Azithromycin
periodontal debridement
Periodontal diseases
Periodontal index
Periodontitis
Root Planing

Áreas temáticas de ASJC Scopus

Odontología General
Medicina General
Profesionales Sanitarios General
Farmacología, toxicología y ciencias farmacéuticas (todo)

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10.17126/joralres.2022.051

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@article{2d31e61ebac44733bbe95119714ba9b4,

title = "EFFECT OF PERIODONTAL DEBRIDEMENT PLUS SYSTEMIC AZITHROMYCIN IN SUBJECTS WITH STAGE III PERIODONTITIS: A RANDOMIZED CONTROLLED CLINICAL TRIAL.",

abstract = "Aim: To evaluate the effect of the systemic administration of azi-thromycin (AZM) as an adjunct to non-surgical periodontal therapy (NSPT) on the clinical and microbiological variables of patients with periodontitis Material and Methods: Eighteen volunteers received NSPT combined with placebo or AZM (500 mg/day) for 3 days (n=9/group). They were monitored clinically for probing pocket depth (PPD), clinical attachment level (CAL), O'Leary index (OI), bleeding on probing (BoP) at baseline and during the first, third and sixth month and microbiologically, at baseline and at 3 and 6 months after therapy, by conventional polymerase chain reaction tests. Results: Fourteen patients completed the study (n=7/group). Differences statistically significant were observed among both groups. The experimental group presented: A PPD mean (p=0.04) significantly lower and PPD reduction (p=0.02), at 6-months post NSPT. Regarding changes (∆), at the third month post NSPT, there was a significant increase in the number of shallow sites (p<0.001) and a decrease in the intermediate sites (p<0.001). In addition, a significant decrease in the mean number of deep sites (p= 0.04) was detected at 6 months post treatment. There was also a significant decrease in periodontal index BoP at 1 (p=0.01), 3 (p<0.001) and 6 (p=0.01) months and OI at 3-and 6-months (p<0.001), post treatment. Regarding the presence of periodontal pathogens, no significant differences were observed, intra and inter groups. Conclusion: AZM as an adjuvant to NSPT provides additional beneficial effects for PPD and BoP compared to NSPT alone.",

keywords = "Azithromycin, periodontal debridement, Periodontal diseases, Periodontal index, Periodontitis, Root Planing, Azithromycin; periodontal debridement; Root Planing; Periodontal index; Periodontitis; Periodontal diseases.",

author = "Mariely Navarrete and H{\'e}ctor O{\~n}ate and Katarina Loyola and Pamela Olivares",

year = "2022",

month = sep,

day = "1",

doi = "10.17126/joralres.2022.051",

language = "English",

volume = "11",

pages = "1--16",

journal = "Journal of Oral Research",

issn = "0719-2460",

publisher = "Universidad de Concepcion",

number = "5",

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TY - JOUR

T1 - EFFECT OF PERIODONTAL DEBRIDEMENT PLUS SYSTEMIC AZITHROMYCIN IN SUBJECTS WITH STAGE III PERIODONTITIS: A RANDOMIZED CONTROLLED CLINICAL TRIAL.

AU - Navarrete, Mariely

AU - Oñate, Héctor

AU - Loyola, Katarina

AU - Olivares, Pamela

PY - 2022/9/1

Y1 - 2022/9/1

N2 - Aim: To evaluate the effect of the systemic administration of azi-thromycin (AZM) as an adjunct to non-surgical periodontal therapy (NSPT) on the clinical and microbiological variables of patients with periodontitis Material and Methods: Eighteen volunteers received NSPT combined with placebo or AZM (500 mg/day) for 3 days (n=9/group). They were monitored clinically for probing pocket depth (PPD), clinical attachment level (CAL), O'Leary index (OI), bleeding on probing (BoP) at baseline and during the first, third and sixth month and microbiologically, at baseline and at 3 and 6 months after therapy, by conventional polymerase chain reaction tests. Results: Fourteen patients completed the study (n=7/group). Differences statistically significant were observed among both groups. The experimental group presented: A PPD mean (p=0.04) significantly lower and PPD reduction (p=0.02), at 6-months post NSPT. Regarding changes (∆), at the third month post NSPT, there was a significant increase in the number of shallow sites (p<0.001) and a decrease in the intermediate sites (p<0.001). In addition, a significant decrease in the mean number of deep sites (p= 0.04) was detected at 6 months post treatment. There was also a significant decrease in periodontal index BoP at 1 (p=0.01), 3 (p<0.001) and 6 (p=0.01) months and OI at 3-and 6-months (p<0.001), post treatment. Regarding the presence of periodontal pathogens, no significant differences were observed, intra and inter groups. Conclusion: AZM as an adjuvant to NSPT provides additional beneficial effects for PPD and BoP compared to NSPT alone.

AB - Aim: To evaluate the effect of the systemic administration of azi-thromycin (AZM) as an adjunct to non-surgical periodontal therapy (NSPT) on the clinical and microbiological variables of patients with periodontitis Material and Methods: Eighteen volunteers received NSPT combined with placebo or AZM (500 mg/day) for 3 days (n=9/group). They were monitored clinically for probing pocket depth (PPD), clinical attachment level (CAL), O'Leary index (OI), bleeding on probing (BoP) at baseline and during the first, third and sixth month and microbiologically, at baseline and at 3 and 6 months after therapy, by conventional polymerase chain reaction tests. Results: Fourteen patients completed the study (n=7/group). Differences statistically significant were observed among both groups. The experimental group presented: A PPD mean (p=0.04) significantly lower and PPD reduction (p=0.02), at 6-months post NSPT. Regarding changes (∆), at the third month post NSPT, there was a significant increase in the number of shallow sites (p<0.001) and a decrease in the intermediate sites (p<0.001). In addition, a significant decrease in the mean number of deep sites (p= 0.04) was detected at 6 months post treatment. There was also a significant decrease in periodontal index BoP at 1 (p=0.01), 3 (p<0.001) and 6 (p=0.01) months and OI at 3-and 6-months (p<0.001), post treatment. Regarding the presence of periodontal pathogens, no significant differences were observed, intra and inter groups. Conclusion: AZM as an adjuvant to NSPT provides additional beneficial effects for PPD and BoP compared to NSPT alone.

KW - Azithromycin

KW - periodontal debridement

KW - Periodontal diseases

KW - Periodontal index

KW - Periodontitis

KW - Root Planing

KW - Azithromycin; periodontal debridement; Root Planing; Periodontal index; Periodontitis; Periodontal diseases.

UR - https://www.scopus.com/pages/publications/85146782399

U2 - 10.17126/joralres.2022.051

DO - 10.17126/joralres.2022.051

M3 - Article

AN - SCOPUS:85146782399

SN - 0719-2460

VL - 11

SP - 1

EP - 16

JO - Journal of Oral Research

JF - Journal of Oral Research

IS - 5

ER -

EFFECT OF PERIODONTAL DEBRIDEMENT PLUS SYSTEMIC AZITHROMYCIN IN SUBJECTS WITH STAGE III PERIODONTITIS: A RANDOMIZED CONTROLLED CLINICAL TRIAL.

Resumen

Palabras clave

Áreas temáticas de ASJC Scopus

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Huella

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