Effect of intermittent treatment with mifepristone on bleeding patterns in Norplant® implant users

María Rebeca Massai, Margarita Pavez, Blanca Fuentealba, Horacio B. Croxatto, Catherine D'Arcangues

Resultado de la investigación: Contribución a una revistaArtículo

34 Citas (Scopus)

Resumen

A double-blind, placebo-controlled, randomized trial, was carried out in 120 Norplant® users to evaluate the effect of mifepristone, 100 mg/day administered for 2 consecutive days every 30 days, on the vaginal bleeding pattern. Treatment was given from months 2-7 of implant use. Volunteers recorded bleeding and spotting days, during treatment and for the ensuing 6-month period. During treatment, women on mifepristone recorded the same frequency of bleeding/spotting episodes but significantly less prolonged bleeding episodes than placebo controls (mean ± SD: 11 ± 3 vs. 22 ± 23 days) and their total number of bleeding days was 35% lower than in the placebo group. After the end of mifepristone use, bleeding patterns were similar in both groups. One pregnancy occurred in the mifepristone-treated group, in month 6 of treatment, the outcome was a healthy male baby. We conclude that intermittent administration of mifepristone can offer a clinically significant improvement of the vaginal bleeding pattern in Norplant users.

Idioma originalInglés
Páginas (desde-hasta)47-54
Número de páginas8
PublicaciónContraception
Volumen70
N.º1
DOI
EstadoPublicada - 1 jul 2004

Áreas temáticas de ASJC Scopus

  • Medicina reproductiva
  • Ginecología y obstetricia

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