Effect of intermittent treatment with mifepristone on bleeding patterns in Norplant® implant users

María Rebeca Massai, Margarita Pavez, Blanca Fuentealba, Horacio B. Croxatto, Catherine D'Arcangues

Resultado de la investigación: Article

34 Citas (Scopus)

Resumen

A double-blind, placebo-controlled, randomized trial, was carried out in 120 Norplant® users to evaluate the effect of mifepristone, 100 mg/day administered for 2 consecutive days every 30 days, on the vaginal bleeding pattern. Treatment was given from months 2-7 of implant use. Volunteers recorded bleeding and spotting days, during treatment and for the ensuing 6-month period. During treatment, women on mifepristone recorded the same frequency of bleeding/spotting episodes but significantly less prolonged bleeding episodes than placebo controls (mean ± SD: 11 ± 3 vs. 22 ± 23 days) and their total number of bleeding days was 35% lower than in the placebo group. After the end of mifepristone use, bleeding patterns were similar in both groups. One pregnancy occurred in the mifepristone-treated group, in month 6 of treatment, the outcome was a healthy male baby. We conclude that intermittent administration of mifepristone can offer a clinically significant improvement of the vaginal bleeding pattern in Norplant users.

Idioma originalEnglish
Páginas (desde-hasta)47-54
Número de páginas8
PublicaciónContraception
Volumen70
N.º1
DOI
EstadoPublished - 1 jul 2004

Huella dactilar

Mifepristone
Levonorgestrel
Hemorrhage
Metrorrhagia
Uterine Hemorrhage
Placebos
Therapeutics
Volunteers
Randomized Controlled Trials
Pregnancy

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Citar esto

Massai, María Rebeca ; Pavez, Margarita ; Fuentealba, Blanca ; Croxatto, Horacio B. ; D'Arcangues, Catherine. / Effect of intermittent treatment with mifepristone on bleeding patterns in Norplant® implant users. En: Contraception. 2004 ; Vol. 70, N.º 1. pp. 47-54.
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abstract = "A double-blind, placebo-controlled, randomized trial, was carried out in 120 Norplant{\circledR} users to evaluate the effect of mifepristone, 100 mg/day administered for 2 consecutive days every 30 days, on the vaginal bleeding pattern. Treatment was given from months 2-7 of implant use. Volunteers recorded bleeding and spotting days, during treatment and for the ensuing 6-month period. During treatment, women on mifepristone recorded the same frequency of bleeding/spotting episodes but significantly less prolonged bleeding episodes than placebo controls (mean ± SD: 11 ± 3 vs. 22 ± 23 days) and their total number of bleeding days was 35{\%} lower than in the placebo group. After the end of mifepristone use, bleeding patterns were similar in both groups. One pregnancy occurred in the mifepristone-treated group, in month 6 of treatment, the outcome was a healthy male baby. We conclude that intermittent administration of mifepristone can offer a clinically significant improvement of the vaginal bleeding pattern in Norplant users.",
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Effect of intermittent treatment with mifepristone on bleeding patterns in Norplant® implant users. / Massai, María Rebeca; Pavez, Margarita; Fuentealba, Blanca; Croxatto, Horacio B.; D'Arcangues, Catherine.

En: Contraception, Vol. 70, N.º 1, 01.07.2004, p. 47-54.

Resultado de la investigación: Article

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AU - Massai, María Rebeca

AU - Pavez, Margarita

AU - Fuentealba, Blanca

AU - Croxatto, Horacio B.

AU - D'Arcangues, Catherine

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