Effect of drimenol and synthetic derivatives on growth and germination of Botrytis cinerea: Evaluation of possible mechanism of action

Christian Robles-Kelly, Julia Rubio, Mario Thomas, Claudia Sedán, Rolando Martinez, Andrés F. Olea, Héctor Carrasco, Lautaro Taborga, Evelyn Silva-Moreno

Resultado de la investigación: Contribución a una revistaArtículo

5 Citas (Scopus)

Resumen

The aim of this study was to determine the antifungal activity of Drimenol (1) and its synthetic derivatives, nordrimenone (2), drimenyl acetate (3), and drimenyl-epoxy-acetate (4), and to establish a possible mechanism of action for drimenol. For that, the effect of each compound on mycelial growth of Botrytis cinerea was assessed. Our results showed that compounds 1, 2, 3 and 4 are able to affect Botrytis cinerea growth with EC50 values of 80, 92, 80 and 314 ppm, respectively. These values suggest that the activity of these compounds is mainly determined by presence of the double bond between carbons 7 and 8 of the drimane ring. In addition, germination of B. cinerea in presence of 40 and 80 ppm of drimenol is reduced almost to a half of the control value. Finally, in order to elucidate a possible mechanism by which drimenol is affecting B. cinerea, the determination of membrane integrity, reactive oxygen species production and gene expression studies of specific genes were performed.

Idioma originalInglés
Páginas (desde-hasta)50-56
Número de páginas7
PublicaciónPesticide Biochemistry and Physiology
Volumen141
DOI
EstadoPublicada - 1 sep 2017

Áreas temáticas de ASJC Scopus

  • Agronomía y cultivos
  • Salud, toxicología y mutagénesis

Huella Profundice en los temas de investigación de 'Effect of drimenol and synthetic derivatives on growth and germination of Botrytis cinerea: Evaluation of possible mechanism of action'. En conjunto forman una huella única.

  • Citar esto

    Robles-Kelly, C., Rubio, J., Thomas, M., Sedán, C., Martinez, R., Olea, A. F., Carrasco, H., Taborga, L., & Silva-Moreno, E. (2017). Effect of drimenol and synthetic derivatives on growth and germination of Botrytis cinerea: Evaluation of possible mechanism of action. Pesticide Biochemistry and Physiology, 141, 50-56. https://doi.org/10.1016/j.pestbp.2016.11.006