Efectos de la injuria renal isquémica aguda en la disfunción extrarenal. Estudio experimental aleatorizado

Camila Salas A., Pablo Lillo A., Alejandro Pacheco V., Tatiana Salomón S., Felipe Lillo A., Lberto Goldsack M., Pablo Cruces R.

Resultado de la investigación: Contribución a una revistaArtículo

1 Cita (Scopus)

Resumen

Background: Acute kidney injury (AKI) is a serious disease that can cause distant organ injuries and is associated with high mortality rates. Objective: To identify the hemodynamic and respiratory dysfunction triggered by AKI, in an animal model of renal ischemia-reperfusion. Method: Twelve anesthetized juvenile pigs (11.9 ± 1.0 kg). Six animals underwent ischemia/reperfusion-induced AKI: 45 min of ischemia and 240 minutes of reperfusion, while the remaining six animals were the control group. In basal conditions and after AKI, a conventional hemodynamic monitoring and transpulmonary thermodilution were performed. At the same time, arterial blood gases and lung mechanics were measured. Results: There was a 29% increase in volumetric preload (221 ± 22 ml/m2 vs 286 ± 16 ml/m2, p = 0.04) and a 58% mean arterial pressure increase (71 ± 6 mmHg vs 112 ± 17 mmHg, p = 0.04) compared to controls, without changes in heart rate, central venous pressure and cardiac output. In addition, an increase of 86% in extravascular lung water (7.6 ± 0.6 ml/kg vs 14.1 ± 1.4 ml/ kg, p = 0.02) was reported, without changes in gas exchange and lung mechanics. Simultaneously, a slight increase in serum creatinine (1.12 ± 0.07 mg/dl vs 1.45 ± 0.10 mg/dl, p = 0.03) was described. Discussion: An early development of hemodynamic and pulmonary dysfunction was observed in this experimental reperfusion model. An increase in volumetric preload and blood pressure associated with a substantial increase in the extravascular lung water were also reported. It is essential serially monitor the hemodynamic and respiratory functions in AKI, including non-uremic subjects.

Título traducido de la contribuciónAcute kidney injury and extrarenal organ dysfunction - A randomized experimental study
Idioma originalEspañol
Páginas (desde-hasta)268-275
Número de páginas8
PublicaciónRevista Chilena de Pediatria
Volumen84
N.º3
DOI
EstadoPublicada - jun 2013

Palabras clave

  • Acute kidney injury
  • Hemodynamics
  • Pulmonary function
  • Renal ischemia

Áreas temáticas de ASJC Scopus

  • Pediatría, perinaltología y salud infantil

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