Efectos de la injuria renal isquémica aguda en la disfunción extrarenal. Estudio experimental aleatorizado

Camila Salas A., Pablo Lillo A., Alejandro Pacheco V., Tatiana Salomón S., Felipe Lillo A., Lberto Goldsack M., Pablo Cruces R.

Resultado de la investigación: Article

1 Cita (Scopus)

Resumen

Background: Acute kidney injury (AKI) is a serious disease that can cause distant organ injuries and is associated with high mortality rates. Objective: To identify the hemodynamic and respiratory dysfunction triggered by AKI, in an animal model of renal ischemia-reperfusion. Method: Twelve anesthetized juvenile pigs (11.9 ± 1.0 kg). Six animals underwent ischemia/reperfusion-induced AKI: 45 min of ischemia and 240 minutes of reperfusion, while the remaining six animals were the control group. In basal conditions and after AKI, a conventional hemodynamic monitoring and transpulmonary thermodilution were performed. At the same time, arterial blood gases and lung mechanics were measured. Results: There was a 29% increase in volumetric preload (221 ± 22 ml/m2 vs 286 ± 16 ml/m2, p = 0.04) and a 58% mean arterial pressure increase (71 ± 6 mmHg vs 112 ± 17 mmHg, p = 0.04) compared to controls, without changes in heart rate, central venous pressure and cardiac output. In addition, an increase of 86% in extravascular lung water (7.6 ± 0.6 ml/kg vs 14.1 ± 1.4 ml/ kg, p = 0.02) was reported, without changes in gas exchange and lung mechanics. Simultaneously, a slight increase in serum creatinine (1.12 ± 0.07 mg/dl vs 1.45 ± 0.10 mg/dl, p = 0.03) was described. Discussion: An early development of hemodynamic and pulmonary dysfunction was observed in this experimental reperfusion model. An increase in volumetric preload and blood pressure associated with a substantial increase in the extravascular lung water were also reported. It is essential serially monitor the hemodynamic and respiratory functions in AKI, including non-uremic subjects.

Idioma originalSpanish
Páginas (desde-hasta)268-275
Número de páginas8
PublicaciónRevista Chilena de Pediatria
Volumen84
N.º3
DOI
EstadoPublished - jun 2013

Huella dactilar

Acute Kidney Injury
Reperfusion
Hemodynamics
Extravascular Lung Water
Ischemia
Mechanics
Lung
Gases
Thermodilution
Central Venous Pressure
Cardiac Output
Creatinine
Arterial Pressure
Theoretical Models
Swine
Animal Models
Heart Rate
Blood Pressure
Kidney
Control Groups

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Citar esto

Salas A., Camila ; Lillo A., Pablo ; Pacheco V., Alejandro ; Salomón S., Tatiana ; Lillo A., Felipe ; Goldsack M., Lberto ; Cruces R., Pablo. / Efectos de la injuria renal isquémica aguda en la disfunción extrarenal. Estudio experimental aleatorizado. En: Revista Chilena de Pediatria. 2013 ; Vol. 84, N.º 3. pp. 268-275.
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title = "Efectos de la injuria renal isqu{\'e}mica aguda en la disfunci{\'o}n extrarenal. Estudio experimental aleatorizado",
abstract = "Background: Acute kidney injury (AKI) is a serious disease that can cause distant organ injuries and is associated with high mortality rates. Objective: To identify the hemodynamic and respiratory dysfunction triggered by AKI, in an animal model of renal ischemia-reperfusion. Method: Twelve anesthetized juvenile pigs (11.9 ± 1.0 kg). Six animals underwent ischemia/reperfusion-induced AKI: 45 min of ischemia and 240 minutes of reperfusion, while the remaining six animals were the control group. In basal conditions and after AKI, a conventional hemodynamic monitoring and transpulmonary thermodilution were performed. At the same time, arterial blood gases and lung mechanics were measured. Results: There was a 29{\%} increase in volumetric preload (221 ± 22 ml/m2 vs 286 ± 16 ml/m2, p = 0.04) and a 58{\%} mean arterial pressure increase (71 ± 6 mmHg vs 112 ± 17 mmHg, p = 0.04) compared to controls, without changes in heart rate, central venous pressure and cardiac output. In addition, an increase of 86{\%} in extravascular lung water (7.6 ± 0.6 ml/kg vs 14.1 ± 1.4 ml/ kg, p = 0.02) was reported, without changes in gas exchange and lung mechanics. Simultaneously, a slight increase in serum creatinine (1.12 ± 0.07 mg/dl vs 1.45 ± 0.10 mg/dl, p = 0.03) was described. Discussion: An early development of hemodynamic and pulmonary dysfunction was observed in this experimental reperfusion model. An increase in volumetric preload and blood pressure associated with a substantial increase in the extravascular lung water were also reported. It is essential serially monitor the hemodynamic and respiratory functions in AKI, including non-uremic subjects.",
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author = "{Salas A.}, Camila and {Lillo A.}, Pablo and {Pacheco V.}, Alejandro and {Salom{\'o}n S.}, Tatiana and {Lillo A.}, Felipe and {Goldsack M.}, Lberto and {Cruces R.}, Pablo",
year = "2013",
month = "6",
doi = "10.4067/S0370-41062013000300004",
language = "Spanish",
volume = "84",
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Efectos de la injuria renal isquémica aguda en la disfunción extrarenal. Estudio experimental aleatorizado. / Salas A., Camila; Lillo A., Pablo; Pacheco V., Alejandro; Salomón S., Tatiana; Lillo A., Felipe; Goldsack M., Lberto; Cruces R., Pablo.

En: Revista Chilena de Pediatria, Vol. 84, N.º 3, 06.2013, p. 268-275.

Resultado de la investigación: Article

TY - JOUR

T1 - Efectos de la injuria renal isquémica aguda en la disfunción extrarenal. Estudio experimental aleatorizado

AU - Salas A., Camila

AU - Lillo A., Pablo

AU - Pacheco V., Alejandro

AU - Salomón S., Tatiana

AU - Lillo A., Felipe

AU - Goldsack M., Lberto

AU - Cruces R., Pablo

PY - 2013/6

Y1 - 2013/6

N2 - Background: Acute kidney injury (AKI) is a serious disease that can cause distant organ injuries and is associated with high mortality rates. Objective: To identify the hemodynamic and respiratory dysfunction triggered by AKI, in an animal model of renal ischemia-reperfusion. Method: Twelve anesthetized juvenile pigs (11.9 ± 1.0 kg). Six animals underwent ischemia/reperfusion-induced AKI: 45 min of ischemia and 240 minutes of reperfusion, while the remaining six animals were the control group. In basal conditions and after AKI, a conventional hemodynamic monitoring and transpulmonary thermodilution were performed. At the same time, arterial blood gases and lung mechanics were measured. Results: There was a 29% increase in volumetric preload (221 ± 22 ml/m2 vs 286 ± 16 ml/m2, p = 0.04) and a 58% mean arterial pressure increase (71 ± 6 mmHg vs 112 ± 17 mmHg, p = 0.04) compared to controls, without changes in heart rate, central venous pressure and cardiac output. In addition, an increase of 86% in extravascular lung water (7.6 ± 0.6 ml/kg vs 14.1 ± 1.4 ml/ kg, p = 0.02) was reported, without changes in gas exchange and lung mechanics. Simultaneously, a slight increase in serum creatinine (1.12 ± 0.07 mg/dl vs 1.45 ± 0.10 mg/dl, p = 0.03) was described. Discussion: An early development of hemodynamic and pulmonary dysfunction was observed in this experimental reperfusion model. An increase in volumetric preload and blood pressure associated with a substantial increase in the extravascular lung water were also reported. It is essential serially monitor the hemodynamic and respiratory functions in AKI, including non-uremic subjects.

AB - Background: Acute kidney injury (AKI) is a serious disease that can cause distant organ injuries and is associated with high mortality rates. Objective: To identify the hemodynamic and respiratory dysfunction triggered by AKI, in an animal model of renal ischemia-reperfusion. Method: Twelve anesthetized juvenile pigs (11.9 ± 1.0 kg). Six animals underwent ischemia/reperfusion-induced AKI: 45 min of ischemia and 240 minutes of reperfusion, while the remaining six animals were the control group. In basal conditions and after AKI, a conventional hemodynamic monitoring and transpulmonary thermodilution were performed. At the same time, arterial blood gases and lung mechanics were measured. Results: There was a 29% increase in volumetric preload (221 ± 22 ml/m2 vs 286 ± 16 ml/m2, p = 0.04) and a 58% mean arterial pressure increase (71 ± 6 mmHg vs 112 ± 17 mmHg, p = 0.04) compared to controls, without changes in heart rate, central venous pressure and cardiac output. In addition, an increase of 86% in extravascular lung water (7.6 ± 0.6 ml/kg vs 14.1 ± 1.4 ml/ kg, p = 0.02) was reported, without changes in gas exchange and lung mechanics. Simultaneously, a slight increase in serum creatinine (1.12 ± 0.07 mg/dl vs 1.45 ± 0.10 mg/dl, p = 0.03) was described. Discussion: An early development of hemodynamic and pulmonary dysfunction was observed in this experimental reperfusion model. An increase in volumetric preload and blood pressure associated with a substantial increase in the extravascular lung water were also reported. It is essential serially monitor the hemodynamic and respiratory functions in AKI, including non-uremic subjects.

KW - Acute kidney injury

KW - Hemodynamics

KW - Pulmonary function

KW - Renal ischemia

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U2 - 10.4067/S0370-41062013000300004

DO - 10.4067/S0370-41062013000300004

M3 - Article

AN - SCOPUS:84885089034

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SP - 268

EP - 275

JO - Revista Chilena de Pediatria

JF - Revista Chilena de Pediatria

SN - 0370-4106

IS - 3

ER -