Early difference in the endocrine profile of long and short lactational amenorrhea

S. Díaz, H. Cárdenas, A. Brandeis, P. Miranda, V. Schiappacasse, A. M. Salvatierra, C. Herreros, M. Serón-Ferré, H. B. Croxatto

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

37 Citas (Scopus)


The endocrine profiles associated with long and short lactational amenorrhea were assessed in a longitudinal study in which morning blood samples were drawn in 48 women from the first postpartum month until the recovery of ovulation and in a cross-sectional study in which the samples were drawn throughout 24 h at the end of the third postpartum month in 10 fully nursing and amenorrheic women. PRL, LH, FSH, estradiol (E2), progesterone, cortisol, and dehydroepiandrosterone sulfate were measured. In both studies we detected a smaller PRL increase in response to suckling (P < 0.001) and higher E2 levels (P < 0.001) in nursing women who ovulated within 6 months postpartum compared to those in women who did not. Such differences were observed early after delivery when all women were fully nursing and amenorrheic. These results suggest some probable sources of variability in the duration of lactational amenorrhea in our population. The greater PRL response to suckling associated with longer amenorrhea may be due to higher sensitivity of the breast-hypothalamus-pituitary system or a stronger suckling stimulus in this group. Differences in plasma E2 levels between longer and shorter periods of amenorrhea may reflect dissimilar endogenous production, intake, or clearence of estrogens.

Idioma originalInglés
Páginas (desde-hasta)196-201
Número de páginas6
PublicaciónJournal of Clinical Endocrinology and Metabolism
EstadoPublicada - 1991

Áreas temáticas de ASJC Scopus

  • Endocrinología, diabetes y metabolismo
  • Bioquímica
  • Endocrinología
  • Bioquímica clínica
  • Bioquímica médica


Profundice en los temas de investigación de 'Early difference in the endocrine profile of long and short lactational amenorrhea'. En conjunto forman una huella única.

Citar esto