Drug and gut microbe relationships: Moving beyond antibiotics

Shreyas V. Kumbhare, Inti Pedroso, Juan A. Ugalde, Valeria Márquez-Miranda, Ranjan Sinha, Daniel E. Almonacid

Producción científica: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

1 Cita (Scopus)

Resumen

Our understanding of drug-microbe relationships has evolved from viewing microbes as mere drug producers to a dynamic, modifiable system where they can serve as drugs or targets of precision pharmacology. This review highlights recent findings on the gut microbiome, particularly focusing on four aspects of research: (i) drugs for bugs, covering recent strategies for targeting gut pathogens; (ii) bugs as drugs, including probiotics; (iii) drugs from bugs, including postbiotics; and (iv) bugs and drugs, discussing additional types of drug–microbe interactions. This review provides a perspective on future translational research, including efficient companion diagnostics in pharmaceutical interventions.

Idioma originalInglés
Número de artículo103797
PublicaciónDrug Discovery Today
Volumen28
N.º11
DOI
EstadoPublicada - nov. 2023

Áreas temáticas de ASJC Scopus

  • Farmacología
  • Descubrimiento de medicamentos

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