Dopamine receptor D3 deficiency results in chronic depression and anxiety

Rodrigo Moraga-Amaro, Hugo Gonzalez, Rodrigo Pacheco, Jimmy Stehberg

Resultado de la investigación: Article

29 Citas (Scopus)

Resumen

The present study assesses the role of D3R in depression. Here we hypothesized that D3R mediates the antidepressant effects of DA. Thus, genetic deficiency of D3R in D3R knockout (D3RKO) mice would yield animals with chronic depressive symptoms. Whereas D3R deficient mice did not show significant alterations in locomotion when tested in the openfield, these animals showed anxiety-like symptoms measured as a significant increase in thigmotaxis at the openfield and a significantly lower time spent in the lit compartment at the light/dark exploration test. D3RKO animals also showed depressive-like symptoms as measured by increased immobility time in the Porsolt forced swim test and the tail suspension test, as well as anhedonia measured in the non-motor dependent sucrose test. In conclusion, D3R deficiency results in anxiety-like and depressive-like symptoms that cannot be attributed to motor dysfunction.

Idioma originalEnglish
Páginas (desde-hasta)186-193
Número de páginas8
PublicaciónBehavioural Brain Research
Volumen274
DOI
EstadoPublished - 1 nov 2014

Huella dactilar

Dopamine D3 Receptors
Anxiety
Depression
Anhedonia
Hindlimb Suspension
Locomotion
Knockout Mice
Antidepressive Agents
Sucrose
Light

ASJC Scopus subject areas

  • Behavioral Neuroscience

Citar esto

Moraga-Amaro, Rodrigo ; Gonzalez, Hugo ; Pacheco, Rodrigo ; Stehberg, Jimmy. / Dopamine receptor D3 deficiency results in chronic depression and anxiety. En: Behavioural Brain Research. 2014 ; Vol. 274. pp. 186-193.
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Dopamine receptor D3 deficiency results in chronic depression and anxiety. / Moraga-Amaro, Rodrigo; Gonzalez, Hugo; Pacheco, Rodrigo; Stehberg, Jimmy.

En: Behavioural Brain Research, Vol. 274, 01.11.2014, p. 186-193.

Resultado de la investigación: Article

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AU - Gonzalez, Hugo

AU - Pacheco, Rodrigo

AU - Stehberg, Jimmy

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