Dissecting the role of redox signaling in neuronal development

Daniel A. Bórquez, Pamela J. Urrutia, Carlos Wilson, Brigitte Van Zundert, Marco Tulio Núñez, Christian González-Billault

Resultado de la investigación: Article

24 Citas (Scopus)

Resumen

The generation of abnormally high levels of reactive oxygen species (ROS) is linked to cellular dysfunction, including neuronal toxicity and neurodegeneration. However, physiological ROS production modulates redox-sensitive roles of several molecules such as transcription factors, signaling proteins, and cytoskeletal components. Changes in the functions of redox-sensitive proteins may be important for defining key aspects of stem cell proliferation and differentiation, neuronal maturation, and neuronal plasticity. In neurons, most of the studies have been focused on the pathological implications of such modifications and only very recently their essential roles in neuronal development and plasticity has been recognized. In this review, we discuss the participation of NADPH oxidases (NOXs) and a family of protein-methionine sulfoxide oxidases, named molecule interacting with CasLs, as regulated enzymatic sources of ROS production in neurons, and describes the contribution of ROS signaling to neurogenesis and differentiation, neurite outgrowth, and neuronal plasticity.

Idioma originalEnglish
Páginas (desde-hasta)506-517
Número de páginas12
PublicaciónJournal of Neurochemistry
Volumen137
N.º4
DOI
EstadoPublished - 1 may 2016

Huella dactilar

Neuronal Plasticity
Oxidation-Reduction
Reactive Oxygen Species
Plasticity
Neurons
Molecules
Cytoskeletal Proteins
NADPH Oxidase
Neurogenesis
Cell proliferation
Stem cells
Toxicity
Cell Differentiation
Proteins
Transcription Factors
Stem Cells
Cell Proliferation

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Citar esto

Bórquez, D. A., Urrutia, P. J., Wilson, C., Van Zundert, B., Núñez, M. T., & González-Billault, C. (2016). Dissecting the role of redox signaling in neuronal development. Journal of Neurochemistry, 137(4), 506-517. https://doi.org/10.1111/jnc.13581
Bórquez, Daniel A. ; Urrutia, Pamela J. ; Wilson, Carlos ; Van Zundert, Brigitte ; Núñez, Marco Tulio ; González-Billault, Christian. / Dissecting the role of redox signaling in neuronal development. En: Journal of Neurochemistry. 2016 ; Vol. 137, N.º 4. pp. 506-517.
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Bórquez, DA, Urrutia, PJ, Wilson, C, Van Zundert, B, Núñez, MT & González-Billault, C 2016, 'Dissecting the role of redox signaling in neuronal development', Journal of Neurochemistry, vol. 137, n.º 4, pp. 506-517. https://doi.org/10.1111/jnc.13581

Dissecting the role of redox signaling in neuronal development. / Bórquez, Daniel A.; Urrutia, Pamela J.; Wilson, Carlos; Van Zundert, Brigitte; Núñez, Marco Tulio; González-Billault, Christian.

En: Journal of Neurochemistry, Vol. 137, N.º 4, 01.05.2016, p. 506-517.

Resultado de la investigación: Article

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Bórquez DA, Urrutia PJ, Wilson C, Van Zundert B, Núñez MT, González-Billault C. Dissecting the role of redox signaling in neuronal development. Journal of Neurochemistry. 2016 may 1;137(4):506-517. https://doi.org/10.1111/jnc.13581