Discovery of small regulatory RNAs extends our understanding of gene regulation in the Acidithiobacillus genus

Amir Shmaryahu, David S. Holmes

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2 Citas (Scopus)


Small regulatory RNAs (srRNAs) control gene expression in Bacteria, usually at the post-transcriptional level, by acting as antisense RNAs that bind targeted mRNAs or by interacting with regulatory proteins. srRNAs are involved in the regulation of a large variety of processes such as plasmid replication, transposition and global genetic circuits that respond to environmental changes. Since their discovery a few years ago, it has become apparent that they are prolific and widespread. In this study, we describe bioinformatic approaches to srRNA discovery in the biomining microorganisms Acidithiobacillus ferrooxidans, A. caldus and A. thiooxidans. Intergenic regions of the annotated genomes were extracted and computationally searched for srRNAs. Candidate srRNAs that were associated with predicted sigma 70 promoters and/or rho-independent terminators were chosen for further study. The resulting potential srRNAs include known examples from other microorganisms and some novel candidates and reveal interesting underlying biology of the Acidithiobacillus genus.

Idioma originalInglés
Título de la publicación alojadaBiohydrometallurgy
Subtítulo de la publicación alojadaFrom the Single Cell to the Environment
Número de páginas4
EstadoPublicada - 1 dic. 2007
Evento17th International Biohydrometallurgy Symposium, IBS 2007 - Frankfurt am Main, Alemania
Duración: 2 sep. 20075 sep. 2007

Serie de la publicación

NombreAdvanced Materials Research
ISSN (versión impresa)1022-6680


Otros17th International Biohydrometallurgy Symposium, IBS 2007
CiudadFrankfurt am Main

Áreas temáticas de ASJC Scopus

  • Ingeniería General


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