Differential participation of angiotensin II type 1 and 2 receptors in the regulation of cardiac cell death triggered by angiotensin II

Pablo Aránguiz-Urroz, Dagoberto Soto, Ariel Contreras, Rodrigo Troncoso, Mario Chiong, José Montenegro, Daniel Venegas, Christian Smolic, Pedro Ayala, Walter G. Thomas, Sergio Lavandero, Guillermo Díaz-Araya

Resultado de la investigación: Contribución a una revistaArtículo

9 Citas (Scopus)

Resumen

Background: The Angiotensin II (Ang II) type 1 (AT"1R) and type 2 (AT"2R) receptors are increased in the heart following myocardial infarction and dilated cardiomyopathy, yet their contribution at a cellular level to compensation and/or failure remains controversial.MethodsWe ectopically expressed AT"1R and AT"2R in cultured adult rat cardiomyocytes and cardiac fibroblasts to investigate Ang II-mediated cardiomyocyte hypertrophy and cardiac cell viability.ResultsIn adult rat cardiomyocytes, Ang II did not induce hypertrophy via the AT"1R, and no effect of Ang II on cell viability was observed following AT"1R or AT"2R expression. In adult rat cardiac fibroblasts, Ang II stimulated cell death by apoptosis via the AT"1R (but not the AT"2R), which required the presence of extracellular calcium, and induced a rapid dissipation of mitochondrial membrane potential, which was significant from 8 h.ConclusionsWe conclude that Ang II/AT"1R triggers apoptosis in adult rat cardiac fibroblasts, which is dependent on Ca2+ influx.

Idioma originalInglés
Páginas (desde-hasta)569-576
Número de páginas8
PublicaciónAmerican Journal of Hypertension
Volumen22
N.º5
DOI
EstadoPublicada - 1 may 2009

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  • Medicina interna

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    Aránguiz-Urroz, P., Soto, D., Contreras, A., Troncoso, R., Chiong, M., Montenegro, J., Venegas, D., Smolic, C., Ayala, P., Thomas, W. G., Lavandero, S., & Díaz-Araya, G. (2009). Differential participation of angiotensin II type 1 and 2 receptors in the regulation of cardiac cell death triggered by angiotensin II. American Journal of Hypertension, 22(5), 569-576. https://doi.org/10.1038/ajh.2009.32