Resumen
The antinociceptive activity of dexketoprofen was studied in mice using the acetic acid writhing test (acute tonic pain), the tail flick test (acute phasic pain) and the formalin assay (inflammatory pain). Isobolographic analysis was used to study the antinociceptive interactions between morphine and paracetamol co-administered with dexketoprofen. In the writhing test, the intraperitoneal administration of dexketoprofen or ketoprofen resulted in parallel dose-response curves with equal efficacy, but higher relative potency for dexketoprofen. In the tail flick test, the curves were parallel with similar efficacy and potency. The administration of morphine or paracetamol in both tests resulted in dose-response curves not parallel with that of dexketoprofen, which showed a potency between morphine and paracetamol. In the formalin assay, the antinociceptive activity of morphine during phase I was 122, 295 and 1695 times higher than dexketoprofen, ketoprofen and paracetamol, respectively. Isobolographic analysis demonstrated that the combination of sub-analgesic doses of dexketoprofen with morphine or with paracetamol was strongly synergic in all three tests. Synergistic drug combinations should improve effective pharmacological treatment of pain, minimizing drug specific adverse effects. These findings are undoubtedly worthy of additional controlled clinical trials in severe pain syndromes.
| Idioma original | English |
|---|---|
| Páginas (desde-hasta) | 291-296 |
| Número de páginas | 6 |
| Publicación | Neuropharmacology |
| Volumen | 52 |
| N.º | 2 |
| DOI | |
| Estado | Published - 1 feb 2007 |
Huella dactilar
ASJC Scopus subject areas
- Pharmacology
- Cellular and Molecular Neuroscience
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Dexketoprofen-induced antinociception in animal models of acute pain : Synergy with morphine and paracetamol. / Miranda, Hugo F.; Puig, Margarita M.; Dursteler, Christian; Prieto, Juan Carlos; Pinardi, Gianni.
En: Neuropharmacology, Vol. 52, N.º 2, 01.02.2007, p. 291-296.Resultado de la investigación: Article
TY - JOUR
T1 - Dexketoprofen-induced antinociception in animal models of acute pain
T2 - Synergy with morphine and paracetamol
AU - Miranda, Hugo F.
AU - Puig, Margarita M.
AU - Dursteler, Christian
AU - Prieto, Juan Carlos
AU - Pinardi, Gianni
PY - 2007/2/1
Y1 - 2007/2/1
N2 - The antinociceptive activity of dexketoprofen was studied in mice using the acetic acid writhing test (acute tonic pain), the tail flick test (acute phasic pain) and the formalin assay (inflammatory pain). Isobolographic analysis was used to study the antinociceptive interactions between morphine and paracetamol co-administered with dexketoprofen. In the writhing test, the intraperitoneal administration of dexketoprofen or ketoprofen resulted in parallel dose-response curves with equal efficacy, but higher relative potency for dexketoprofen. In the tail flick test, the curves were parallel with similar efficacy and potency. The administration of morphine or paracetamol in both tests resulted in dose-response curves not parallel with that of dexketoprofen, which showed a potency between morphine and paracetamol. In the formalin assay, the antinociceptive activity of morphine during phase I was 122, 295 and 1695 times higher than dexketoprofen, ketoprofen and paracetamol, respectively. Isobolographic analysis demonstrated that the combination of sub-analgesic doses of dexketoprofen with morphine or with paracetamol was strongly synergic in all three tests. Synergistic drug combinations should improve effective pharmacological treatment of pain, minimizing drug specific adverse effects. These findings are undoubtedly worthy of additional controlled clinical trials in severe pain syndromes.
AB - The antinociceptive activity of dexketoprofen was studied in mice using the acetic acid writhing test (acute tonic pain), the tail flick test (acute phasic pain) and the formalin assay (inflammatory pain). Isobolographic analysis was used to study the antinociceptive interactions between morphine and paracetamol co-administered with dexketoprofen. In the writhing test, the intraperitoneal administration of dexketoprofen or ketoprofen resulted in parallel dose-response curves with equal efficacy, but higher relative potency for dexketoprofen. In the tail flick test, the curves were parallel with similar efficacy and potency. The administration of morphine or paracetamol in both tests resulted in dose-response curves not parallel with that of dexketoprofen, which showed a potency between morphine and paracetamol. In the formalin assay, the antinociceptive activity of morphine during phase I was 122, 295 and 1695 times higher than dexketoprofen, ketoprofen and paracetamol, respectively. Isobolographic analysis demonstrated that the combination of sub-analgesic doses of dexketoprofen with morphine or with paracetamol was strongly synergic in all three tests. Synergistic drug combinations should improve effective pharmacological treatment of pain, minimizing drug specific adverse effects. These findings are undoubtedly worthy of additional controlled clinical trials in severe pain syndromes.
KW - Antinociception
KW - Dexketoprofen
KW - Formalin assay
KW - Isobologram
KW - Ketoprofen
KW - Morphine
KW - Paracetamol
KW - Synergy
KW - Tail flick test
KW - Writhing test
UR - http://www.scopus.com/inward/record.url?scp=33846438213&partnerID=8YFLogxK
U2 - 10.1016/j.neuropharm.2006.07.025
DO - 10.1016/j.neuropharm.2006.07.025
M3 - Article
C2 - 17074372
AN - SCOPUS:33846438213
VL - 52
SP - 291
EP - 296
JO - Neuropharmacology
JF - Neuropharmacology
SN - 0028-3908
IS - 2
ER -