Depletion study of three formulations of flumequine in edible tissues and drug transfer into chicken feathers

J. Cornejo, L. Lapierre, D. Iragüen, N. Pizarro, H. Hidalgo, B. San Martín

Resultado de la investigación: Article

23 Citas (Scopus)

Resumen

To ensure the delivery of safe animal products to consumers, withdrawal times (WDT) of drugs must be respected. Drugs administered in therapies can also reach nonedible tissues (for humans) such as feathers; this transfer is of concern as feather meal is used in diets of food producing animals, being this a possible source of residue contamination of final products for human consumption. WDTs of three flumequine formulations (10%, 80% premix powder and 20% solution) as well as the transfer of this drug into feathers were determined. One hundred and twenty broiler chickens were allocated into four experimental groups (36 birds each). Three of them were treated with 24mg/kg bw orally for five consecutive days of each flumequine formulation, whereas one group remained untreated (12 birds as control group). After the treatment ended, six chickens of each experimental group and two controls were slaughtered daily for 6days. Samples of muscle, liver and feathers were collected and analyzed by liquid chromatography tandem mass spectrometry (LC MS/MS). The WDTs showed differences between formulations. Flumequine concentrations found in feathers remained high during WDT and after this period, thus suggesting that the WDTs estimated for the pharmaceutical formulation of flumequine do not guarantee the absence of this drug in chicken nonedible tissues such as feathers.

Idioma originalEnglish
Páginas (desde-hasta)168-175
Número de páginas8
PublicaciónJournal of Veterinary Pharmacology and Therapeutics
Volumen34
N.º2
DOI
EstadoPublished - abr 2011

Huella dactilar

flumequine
Feathers
feathers
Chickens
chickens
drugs
Pharmaceutical Preparations
Birds
drug formulations
feather meal
animal products
birds
Drug Compounding
Control Groups
liquid chromatography
Tandem Mass Spectrometry
powders
Liquid Chromatography
Powders
broiler chickens

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

Citar esto

Cornejo, J. ; Lapierre, L. ; Iragüen, D. ; Pizarro, N. ; Hidalgo, H. ; Martín, B. San. / Depletion study of three formulations of flumequine in edible tissues and drug transfer into chicken feathers. En: Journal of Veterinary Pharmacology and Therapeutics. 2011 ; Vol. 34, N.º 2. pp. 168-175.
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abstract = "To ensure the delivery of safe animal products to consumers, withdrawal times (WDT) of drugs must be respected. Drugs administered in therapies can also reach nonedible tissues (for humans) such as feathers; this transfer is of concern as feather meal is used in diets of food producing animals, being this a possible source of residue contamination of final products for human consumption. WDTs of three flumequine formulations (10{\%}, 80{\%} premix powder and 20{\%} solution) as well as the transfer of this drug into feathers were determined. One hundred and twenty broiler chickens were allocated into four experimental groups (36 birds each). Three of them were treated with 24mg/kg bw orally for five consecutive days of each flumequine formulation, whereas one group remained untreated (12 birds as control group). After the treatment ended, six chickens of each experimental group and two controls were slaughtered daily for 6days. Samples of muscle, liver and feathers were collected and analyzed by liquid chromatography tandem mass spectrometry (LC MS/MS). The WDTs showed differences between formulations. Flumequine concentrations found in feathers remained high during WDT and after this period, thus suggesting that the WDTs estimated for the pharmaceutical formulation of flumequine do not guarantee the absence of this drug in chicken nonedible tissues such as feathers.",
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Depletion study of three formulations of flumequine in edible tissues and drug transfer into chicken feathers. / Cornejo, J.; Lapierre, L.; Iragüen, D.; Pizarro, N.; Hidalgo, H.; Martín, B. San.

En: Journal of Veterinary Pharmacology and Therapeutics, Vol. 34, N.º 2, 04.2011, p. 168-175.

Resultado de la investigación: Article

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