Delivery of gold nanoparticles to the brain by conjugation with a peptide that recognizes the transferrin receptor

Roger Prades, Simón Guerrero, Eyleen Araya, Claudia Molina, Edison Salas, Esther Zurita, Javier Selva, Gustavo Egea, Carmen López-Iglesias, Meritxell Teixidó, Marcelo J. Kogan, Ernest Giralt

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

233 Citas (Scopus)

Resumen

The treatment of Alzheimer's disease and many other brain-related disorders is limited because of the presence of the blood-brain barrier, which highly regulate the crossing of drugs. Metal nanoparticles have unique features that could contribute to the development of new therapies for these diseases. Nanoparticles have the capacity to carry several molecules of a drug; furthermore, their unique physico-chemical properties allow, for example, photothermal therapy to produce molecular surgery to destroy tumor cells and toxic structures. Recently, we demonstrated that gold nanoparticles conjugated to the peptide CLPFFD are useful to destroy the toxic aggregates of β-amyloid, similar to the ones found in the brains of patients with Alzheimer's disease. However, nanoparticles, like many other compounds, have null or very low capacity to cross the blood-brain barrier. In order to devise a strategy to improve drug delivery to the brain, here we introduced the peptide sequence THRPPMWSPVWP into the gold nanoparticle-CLPFFD conjugate. This peptide sequence interacts with the transferrin receptor present in the microvascular endothelial cells of the blood-brain barrier, thus causing an increase in the permeability of the conjugate in brain, as shown by experiments in vitro and in vivo. Our results are highly relevant for the therapeutic applications of gold nanoparticles for molecular surgery in the treatment of neurodegenerative diseases such as Alzheimer's disease.

Idioma originalInglés
Páginas (desde-hasta)7194-7205
Número de páginas12
PublicaciónBiomaterials
Volumen33
N.º29
DOI
EstadoPublicada - oct. 2012

Áreas temáticas de ASJC Scopus

  • Biofísica
  • Bioingeniería
  • Cerámicos y compuestos
  • Biomateriales
  • Mecánica de materiales

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