Cytokines in the respiratory airway as biomarkers of severity and prognosis for respiratory syncytial virus infection: An update

Yaneisi Vázquez, Liliana González, Loreani Noguera, Pablo A. González, Claudia A. Riedel, Pablo Bertrand, Susan M. Bueno

Resultado de la investigación: Review article

Resumen

The human respiratory syncytial virus (hRSV) is one of the most important causes of upper and lower respiratory tract infections in children and the main cause of bronchiolitis worldwide. Disease manifestations caused by hRSV may vary from mild to severe, occasionally requiring admission and hospitalization in intensive care units. Despite the high morbidity rates associated to bronchiolitis, treatment options against hRSV are limited and there are no current vaccination strategies to prevent infection. Importantly, the early identification of high-risk patients can help improve disease management and prevent complications associated with hRSV infection. Recently, the characterization of pro- and anti-inflammatory cytokine patterns produced during hRSV-related inflammatory processes has allowed the identification of potential prognosis biomarkers. A suitable biomarker should allow predicting the severity of the infection in a simple and opportune manner and should ideally be obtained from non-invasive samples. Among the cytokines associated with hRSV disease severity, IL-8, interferon-alpha (IFN-alpha), and IL-6, as well as the Th2-type cytokines thymic stromal lymphopoietin (TSLP), IL-3, and IL-33 have been highlighted as molecules with prognostic value in hRSV infections. In this review, we discuss current studies that describe molecules produced by patients during hRSV infection and their potential as biomarkers to anticipate the severity of the disease caused by this virus.

Idioma originalEnglish
Número de artículo1154
PublicaciónFrontiers in Immunology
Volumen10
N.ºJUN
DOI
EstadoPublished - 1 ene 2019

Huella dactilar

Human respiratory syncytial virus
Respiratory Syncytial Virus Infections
Biomarkers
Cytokines
Bronchiolitis
Virus Diseases
Interleukin-3
Disease Management
Infection
Interleukin-8
Interferon-alpha
Respiratory Tract Infections
Intensive Care Units
Interleukin-6
Vaccination
Hospitalization
Anti-Inflammatory Agents
Morbidity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Citar esto

Vázquez, Yaneisi ; González, Liliana ; Noguera, Loreani ; González, Pablo A. ; Riedel, Claudia A. ; Bertrand, Pablo ; Bueno, Susan M. / Cytokines in the respiratory airway as biomarkers of severity and prognosis for respiratory syncytial virus infection : An update. En: Frontiers in Immunology. 2019 ; Vol. 10, N.º JUN.
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Cytokines in the respiratory airway as biomarkers of severity and prognosis for respiratory syncytial virus infection : An update. / Vázquez, Yaneisi; González, Liliana; Noguera, Loreani; González, Pablo A.; Riedel, Claudia A.; Bertrand, Pablo; Bueno, Susan M.

En: Frontiers in Immunology, Vol. 10, N.º JUN, 1154, 01.01.2019.

Resultado de la investigación: Review article

TY - JOUR

T1 - Cytokines in the respiratory airway as biomarkers of severity and prognosis for respiratory syncytial virus infection

T2 - An update

AU - Vázquez, Yaneisi

AU - González, Liliana

AU - Noguera, Loreani

AU - González, Pablo A.

AU - Riedel, Claudia A.

AU - Bertrand, Pablo

AU - Bueno, Susan M.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The human respiratory syncytial virus (hRSV) is one of the most important causes of upper and lower respiratory tract infections in children and the main cause of bronchiolitis worldwide. Disease manifestations caused by hRSV may vary from mild to severe, occasionally requiring admission and hospitalization in intensive care units. Despite the high morbidity rates associated to bronchiolitis, treatment options against hRSV are limited and there are no current vaccination strategies to prevent infection. Importantly, the early identification of high-risk patients can help improve disease management and prevent complications associated with hRSV infection. Recently, the characterization of pro- and anti-inflammatory cytokine patterns produced during hRSV-related inflammatory processes has allowed the identification of potential prognosis biomarkers. A suitable biomarker should allow predicting the severity of the infection in a simple and opportune manner and should ideally be obtained from non-invasive samples. Among the cytokines associated with hRSV disease severity, IL-8, interferon-alpha (IFN-alpha), and IL-6, as well as the Th2-type cytokines thymic stromal lymphopoietin (TSLP), IL-3, and IL-33 have been highlighted as molecules with prognostic value in hRSV infections. In this review, we discuss current studies that describe molecules produced by patients during hRSV infection and their potential as biomarkers to anticipate the severity of the disease caused by this virus.

AB - The human respiratory syncytial virus (hRSV) is one of the most important causes of upper and lower respiratory tract infections in children and the main cause of bronchiolitis worldwide. Disease manifestations caused by hRSV may vary from mild to severe, occasionally requiring admission and hospitalization in intensive care units. Despite the high morbidity rates associated to bronchiolitis, treatment options against hRSV are limited and there are no current vaccination strategies to prevent infection. Importantly, the early identification of high-risk patients can help improve disease management and prevent complications associated with hRSV infection. Recently, the characterization of pro- and anti-inflammatory cytokine patterns produced during hRSV-related inflammatory processes has allowed the identification of potential prognosis biomarkers. A suitable biomarker should allow predicting the severity of the infection in a simple and opportune manner and should ideally be obtained from non-invasive samples. Among the cytokines associated with hRSV disease severity, IL-8, interferon-alpha (IFN-alpha), and IL-6, as well as the Th2-type cytokines thymic stromal lymphopoietin (TSLP), IL-3, and IL-33 have been highlighted as molecules with prognostic value in hRSV infections. In this review, we discuss current studies that describe molecules produced by patients during hRSV infection and their potential as biomarkers to anticipate the severity of the disease caused by this virus.

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KW - Cytokines

KW - HRSV

KW - LRTI

KW - Prognosis

KW - Severity

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JO - Frontiers in Immunology

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