Resumen
The human respiratory syncytial virus (hRSV) is one of the most important causes of upper and lower respiratory tract infections in children and the main cause of bronchiolitis worldwide. Disease manifestations caused by hRSV may vary from mild to severe, occasionally requiring admission and hospitalization in intensive care units. Despite the high morbidity rates associated to bronchiolitis, treatment options against hRSV are limited and there are no current vaccination strategies to prevent infection. Importantly, the early identification of high-risk patients can help improve disease management and prevent complications associated with hRSV infection. Recently, the characterization of pro- and anti-inflammatory cytokine patterns produced during hRSV-related inflammatory processes has allowed the identification of potential prognosis biomarkers. A suitable biomarker should allow predicting the severity of the infection in a simple and opportune manner and should ideally be obtained from non-invasive samples. Among the cytokines associated with hRSV disease severity, IL-8, interferon-alpha (IFN-alpha), and IL-6, as well as the Th2-type cytokines thymic stromal lymphopoietin (TSLP), IL-3, and IL-33 have been highlighted as molecules with prognostic value in hRSV infections. In this review, we discuss current studies that describe molecules produced by patients during hRSV infection and their potential as biomarkers to anticipate the severity of the disease caused by this virus.
| Idioma original | English |
|---|---|
| Número de artículo | 1154 |
| Publicación | Frontiers in Immunology |
| Volumen | 10 |
| N.º | JUN |
| DOI | |
| Estado | Published - 1 ene 2019 |
Huella dactilar
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
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Cytokines in the respiratory airway as biomarkers of severity and prognosis for respiratory syncytial virus infection : An update. / Vázquez, Yaneisi; González, Liliana; Noguera, Loreani; González, Pablo A.; Riedel, Claudia A.; Bertrand, Pablo; Bueno, Susan M.
En: Frontiers in Immunology, Vol. 10, N.º JUN, 1154, 01.01.2019.Resultado de la investigación: Review article
TY - JOUR
T1 - Cytokines in the respiratory airway as biomarkers of severity and prognosis for respiratory syncytial virus infection
T2 - An update
AU - Vázquez, Yaneisi
AU - González, Liliana
AU - Noguera, Loreani
AU - González, Pablo A.
AU - Riedel, Claudia A.
AU - Bertrand, Pablo
AU - Bueno, Susan M.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - The human respiratory syncytial virus (hRSV) is one of the most important causes of upper and lower respiratory tract infections in children and the main cause of bronchiolitis worldwide. Disease manifestations caused by hRSV may vary from mild to severe, occasionally requiring admission and hospitalization in intensive care units. Despite the high morbidity rates associated to bronchiolitis, treatment options against hRSV are limited and there are no current vaccination strategies to prevent infection. Importantly, the early identification of high-risk patients can help improve disease management and prevent complications associated with hRSV infection. Recently, the characterization of pro- and anti-inflammatory cytokine patterns produced during hRSV-related inflammatory processes has allowed the identification of potential prognosis biomarkers. A suitable biomarker should allow predicting the severity of the infection in a simple and opportune manner and should ideally be obtained from non-invasive samples. Among the cytokines associated with hRSV disease severity, IL-8, interferon-alpha (IFN-alpha), and IL-6, as well as the Th2-type cytokines thymic stromal lymphopoietin (TSLP), IL-3, and IL-33 have been highlighted as molecules with prognostic value in hRSV infections. In this review, we discuss current studies that describe molecules produced by patients during hRSV infection and their potential as biomarkers to anticipate the severity of the disease caused by this virus.
AB - The human respiratory syncytial virus (hRSV) is one of the most important causes of upper and lower respiratory tract infections in children and the main cause of bronchiolitis worldwide. Disease manifestations caused by hRSV may vary from mild to severe, occasionally requiring admission and hospitalization in intensive care units. Despite the high morbidity rates associated to bronchiolitis, treatment options against hRSV are limited and there are no current vaccination strategies to prevent infection. Importantly, the early identification of high-risk patients can help improve disease management and prevent complications associated with hRSV infection. Recently, the characterization of pro- and anti-inflammatory cytokine patterns produced during hRSV-related inflammatory processes has allowed the identification of potential prognosis biomarkers. A suitable biomarker should allow predicting the severity of the infection in a simple and opportune manner and should ideally be obtained from non-invasive samples. Among the cytokines associated with hRSV disease severity, IL-8, interferon-alpha (IFN-alpha), and IL-6, as well as the Th2-type cytokines thymic stromal lymphopoietin (TSLP), IL-3, and IL-33 have been highlighted as molecules with prognostic value in hRSV infections. In this review, we discuss current studies that describe molecules produced by patients during hRSV infection and their potential as biomarkers to anticipate the severity of the disease caused by this virus.
KW - Biomarker
KW - Cytokines
KW - HRSV
KW - LRTI
KW - Prognosis
KW - Severity
UR - http://www.scopus.com/inward/record.url?scp=85068469385&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2019.01154
DO - 10.3389/fimmu.2019.01154
M3 - Review article
C2 - 31214165
AN - SCOPUS:85068469385
VL - 10
JO - Frontiers in Immunology
JF - Frontiers in Immunology
SN - 1664-3224
IS - JUN
M1 - 1154
ER -