Cysteine metabolism-related genes and bacterial resistance to potassium tellurite

Derie E. Fuentes, Eugenia L. Fuentes, Miguel E. Castro, José M. Pérez, Manuel A. Araya, Thomas G. Chasteen, Sergio E. Pichuantes, Claudio C. Vâsquez

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

40 Citas (Scopus)

Resumen

Tellurite exerts a deleterious effect on a number of small molecules containing sulfur moieties that have a recognized role in cellular oxidative stress. Because cysteine is involved in the biosynthesis of glutathione and other sulfur-containing compounds, we investigated the expression of Geobacillus stearothermophilus V cysteine-related genes cob A, cysK, and iscS and Escherichia coli cysteine regulon genes under conditions that included the addition of K2TeO3 to the culture medium. Results showed that cell tolerance to tellurite correlates with the expression level of the cysteine metabolic genes and that these genes are up-regulated when tellurite is present in the growth medium.

Idioma originalInglés
Páginas (desde-hasta)8953-8960
Número de páginas8
PublicaciónJournal of Bacteriology
Volumen189
N.º24
DOI
EstadoPublicada - dic 2007

Áreas temáticas de ASJC Scopus

  • Microbiología
  • Biología molecular

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