Cysteine metabolism-related genes and bacterial resistance to potassium tellurite

Derie E. Fuentes; Eugenia L. Fuentes; Miguel E. Castro; José M. Pérez; Manuel A. Araya; Thomas G. Chasteen; Sergio E. Pichuantes; Claudio C. Vâsquez

doi:10.1128/JB.01252-07

Cysteine metabolism-related genes and bacterial resistance to potassium tellurite

Derie E. Fuentes, Eugenia L. Fuentes, Miguel E. Castro, José M. Pérez, Manuel A. Araya, Thomas G. Chasteen, Sergio E. Pichuantes, Claudio C. Vâsquez

Facultad de Ciencias de la Vida

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

46 Citas (Scopus)

Resumen

Tellurite exerts a deleterious effect on a number of small molecules containing sulfur moieties that have a recognized role in cellular oxidative stress. Because cysteine is involved in the biosynthesis of glutathione and other sulfur-containing compounds, we investigated the expression of Geobacillus stearothermophilus V cysteine-related genes cob A, cysK, and iscS and Escherichia coli cysteine regulon genes under conditions that included the addition of K₂TeO₃ to the culture medium. Results showed that cell tolerance to tellurite correlates with the expression level of the cysteine metabolic genes and that these genes are up-regulated when tellurite is present in the growth medium.

Idioma original	Inglés
Páginas (desde-hasta)	8953-8960
Número de páginas	8
Publicación	Journal of Bacteriology
Volumen	189
N.º	24
DOI	https://doi.org/10.1128/JB.01252-07
Estado	Publicada - dic. 2007

Áreas temáticas de ASJC Scopus

Microbiología
Biología molecular

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10.1128/JB.01252-07

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title = "Cysteine metabolism-related genes and bacterial resistance to potassium tellurite",

abstract = "Tellurite exerts a deleterious effect on a number of small molecules containing sulfur moieties that have a recognized role in cellular oxidative stress. Because cysteine is involved in the biosynthesis of glutathione and other sulfur-containing compounds, we investigated the expression of Geobacillus stearothermophilus V cysteine-related genes cob A, cysK, and iscS and Escherichia coli cysteine regulon genes under conditions that included the addition of K2TeO3 to the culture medium. Results showed that cell tolerance to tellurite correlates with the expression level of the cysteine metabolic genes and that these genes are up-regulated when tellurite is present in the growth medium.",

author = "Fuentes, {Derie E.} and Fuentes, {Eugenia L.} and Castro, {Miguel E.} and P{\'e}rez, {Jos{\'e} M.} and Araya, {Manuel A.} and Chasteen, {Thomas G.} and Pichuantes, {Sergio E.} and V{\^a}squez, {Claudio C.}",

year = "2007",

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T1 - Cysteine metabolism-related genes and bacterial resistance to potassium tellurite

AU - Fuentes, Derie E.

AU - Fuentes, Eugenia L.

AU - Castro, Miguel E.

AU - Pérez, José M.

AU - Araya, Manuel A.

AU - Chasteen, Thomas G.

AU - Pichuantes, Sergio E.

AU - Vâsquez, Claudio C.

PY - 2007/12

Y1 - 2007/12

N2 - Tellurite exerts a deleterious effect on a number of small molecules containing sulfur moieties that have a recognized role in cellular oxidative stress. Because cysteine is involved in the biosynthesis of glutathione and other sulfur-containing compounds, we investigated the expression of Geobacillus stearothermophilus V cysteine-related genes cob A, cysK, and iscS and Escherichia coli cysteine regulon genes under conditions that included the addition of K2TeO3 to the culture medium. Results showed that cell tolerance to tellurite correlates with the expression level of the cysteine metabolic genes and that these genes are up-regulated when tellurite is present in the growth medium.

AB - Tellurite exerts a deleterious effect on a number of small molecules containing sulfur moieties that have a recognized role in cellular oxidative stress. Because cysteine is involved in the biosynthesis of glutathione and other sulfur-containing compounds, we investigated the expression of Geobacillus stearothermophilus V cysteine-related genes cob A, cysK, and iscS and Escherichia coli cysteine regulon genes under conditions that included the addition of K2TeO3 to the culture medium. Results showed that cell tolerance to tellurite correlates with the expression level of the cysteine metabolic genes and that these genes are up-regulated when tellurite is present in the growth medium.

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SN - 0021-9193

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JO - Journal of Bacteriology

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Cysteine metabolism-related genes and bacterial resistance to potassium tellurite

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