Crystal structure, Hirshfeld surface analysis, and molecular dynamics simulations of two isostructural N-propargyl-4-(2-oxopyrrolidin-1-yl)-1,2,3,4-tetrahydroquinolines

Fausto M. Güiza, Yeray A. Rodríguez-Núñez, David Ramírez, Arnold R. Romero Bohórquez, José Antonio Henao, Robert A. Toro, José Miguel Delgado, Graciela Díaz de Delgado

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Resumen

Two new N-propargyl-4-(2-oxopyrrolidin-1-yl)-1,2,3,4-tetrahydroquinoline derivatives (4a and 4b), have been efficiently prepared through a one-pot InCl3-catalyzed cationic Povarov reaction between N-propargylanilines (1a and 1b), formaldehyde (2) and N-vinyl-pyrrolidin-2-one (3). These compounds were characterized by ATR-FTIR spectroscopy, 1H/13C NMR spectroscopy, ESI-IT mass spectrometry, and by single-crystal X-ray diffraction. N-propargyl-6-methyl-4-(2′-oxopyrrolidin-1′-yl)-1,2,3,4-tetrahydroquinoline (4a) and N-propargyl-6-chloro-4-(2′-oxopyrrolidin-1′-yl)-1,2,3,4-tetrahydroquinoline (4b) are isostructural and crystallize in space group P21/c. The crystal structures are characterized by inversion-related interpenetrated helices along the b-axis that form columns along the c-axis. C—H···O, C—H···C, and C—H···π(aryl) for 4a and C—H···O, C—H···Cl, and C—H···π(aryl) for 4b interactions occur within the columns which are connected by C—H···π(propargyl) interactions. These features were further visualized by Hirshfeld surface analysis and energy frameworks calculations and evaluated by the EXY enrichment ratio. Molecular dynamics simulations show that these compounds are promising monoamine oxidase B (MAO‐B) inhibitors, since they interact with MAO-B in a similar manner as rasagiline, a drug commonly used in the treatment of Parkinson's and Alzheimer's diseases.

Idioma originalInglés
Número de artículo132280
PublicaciónJournal of Molecular Structure
Volumen1254
DOI
EstadoPublicada - 15 abr. 2022

Áreas temáticas de ASJC Scopus

  • Química analítica
  • Espectroscopia
  • Química orgánica
  • Química inorgánica

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