Copy number variants in lipid metabolism genes are associated with gallstones disease in men

Eduardo Pérez-Palma, Bernabé I. Bustos, Dennis Lal, Stephan Buch, Lorena Azocar, Mohammad Reza Toliat, Wolfgang Lieb, Andre Franke, Sebastian Hinz, Greta Burmeister, Witigo von Shönfels, Clemens Schafmayer, Peter Ahnert, Henry Völzke, Uwe Völker, Georg Homuth, Markus M. Lerch, Klaus Puschel, Rodrigo A. Gutiérrez, Jochen HampePeter Nürnberg, Juan Francisco Miquel, Giancarlo V. De Ferrari

Resultado de la investigación: Contribución a una revistaArtículo

Resumen

Gallstones Disease (GSD) is one of the most common digestive diseases requiring hospitalization and surgical procedures in the world. GSD has a high prevalence in populations with European or Amerindian ancestry (10–20%) and the influence of genetic factors is broadly acknowledged. However, known genetic variants do not entirely explain the disease heritability suggesting that additional genetic variants remain to be identified. Here, we examined the association of copy number variants (CNVs) with GSD in a sample of 4778 individuals (1929 GSD cases and 2849 controls) including two European cohorts from Germany (n = 3702) and one admixed Latin American cohort from Chile (n = 1076). We detected 2936 large and rare CNVs events (size > 100 kb, frequency < 1%). Case-control burden analysis and generalized linear regression models revealed significant association of CNVs with GSD in men, with the strongest effect observed with CNVs overlapping lipid metabolism genes (p-value = 6.54 × 10–4; OR = 2.76; CI 95% = 1.53–4.89). Our results indicate a clear link between CNVs and GSD in men and provides additional evidence that the genetic components of risk for GSD are complex, can be sex specific and include CNVs affecting genes involved in lipid metabolism.

Idioma originalInglés
Páginas (desde-hasta)264-273
Número de páginas10
PublicaciónEuropean Journal of Human Genetics
Volumen28
N.º2
DOI
EstadoEn prensa - 1 ene 2019

Áreas temáticas de ASJC Scopus

  • Genética
  • Genética (clínica)

Huella Profundice en los temas de investigación de 'Copy number variants in lipid metabolism genes are associated with gallstones disease in men'. En conjunto forman una huella única.

  • Citar esto

    Pérez-Palma, E., Bustos, B. I., Lal, D., Buch, S., Azocar, L., Toliat, M. R., Lieb, W., Franke, A., Hinz, S., Burmeister, G., von Shönfels, W., Schafmayer, C., Ahnert, P., Völzke, H., Völker, U., Homuth, G., Lerch, M. M., Puschel, K., Gutiérrez, R. A., ... De Ferrari, G. V. (Aceptado/En prensa). Copy number variants in lipid metabolism genes are associated with gallstones disease in men. European Journal of Human Genetics, 28(2), 264-273. https://doi.org/10.1038/s41431-019-0501-7