TY - JOUR
T1 - Copper brain homeostasis
T2 - Role of amyloid precursor protein and prion protein
AU - Inestrosa, Nibaldo C.
AU - Cerpa, Waldo
AU - Varela-Nallar, Lorena
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005/9
Y1 - 2005/9
N2 - The main proteins associated with Alzheimer's and prion diseases (amyloid precursor protein (APP) and prion protein (PrPC), respectively, have binding sites for copper and it has therefore been suggested that they play a role in copper metabolism. Here, we review evidence indicating that the copper binding domains (CuBD) of APP and PrPC are able to modulate the oxidation state of copper, and prevent neurotoxic effects and memory impairments induced by copper. Results with transgenic and other animal models have established the relation between these pathogenic proteins and copper. In particular, APP transgenic models, suggest a beneficial effect for copper in AD.
AB - The main proteins associated with Alzheimer's and prion diseases (amyloid precursor protein (APP) and prion protein (PrPC), respectively, have binding sites for copper and it has therefore been suggested that they play a role in copper metabolism. Here, we review evidence indicating that the copper binding domains (CuBD) of APP and PrPC are able to modulate the oxidation state of copper, and prevent neurotoxic effects and memory impairments induced by copper. Results with transgenic and other animal models have established the relation between these pathogenic proteins and copper. In particular, APP transgenic models, suggest a beneficial effect for copper in AD.
KW - APP
KW - Copper
KW - Copper binding domain
KW - Metal homeostasis
KW - Prion protein
UR - http://www.scopus.com/inward/record.url?scp=27444445191&partnerID=8YFLogxK
U2 - 10.1080/15216540500264620
DO - 10.1080/15216540500264620
M3 - Review article
C2 - 16203684
AN - SCOPUS:27444445191
SN - 1521-6543
VL - 57
SP - 645
EP - 650
JO - IUBMB Life
JF - IUBMB Life
IS - 9
ER -