Contribution of autophagy to antiviral immunity

Emma Rey-Jurado, Claudia A. Riedel, Pablo A. González, Susan M. Bueno, Alexis M. Kalergis

Resultado de la investigación: Article

21 Citas (Scopus)

Resumen

Although identified in the 1960's, interest in autophagy has significantly increased in the past decade with notable research efforts oriented at understanding as to how this multi-protein complex operates and is regulated. Autophagy is commonly defined as a "self-eating" process evolved by eukaryotic cells to recycle senescent organelles and expired proteins, which is significantly increased during cellular stress responses. In addition, autophagy can also play important roles during human diseases, such as cancer, neurodegenerative and autoimmune disorders. Furthermore, novel findings suggest that autophagy contributes to the host defense against microbial infections. In this article, we review the role of macroautophagy in antiviral immune responses and discuss molecular mechanisms evolved by viral pathogens to evade this process. A role for autophagy as an effector mechanism used both, by innate and adaptive immunity is also discussed.

Idioma originalEnglish
Páginas (desde-hasta)3461-3470
Número de páginas10
PublicaciónFEBS Letters
Volumen589
N.º22
DOI
EstadoPublished - 3 may 2015

Huella dactilar

Autophagy
Antiviral Agents
Immunity
Pathogens
Proteins
Eukaryotic Cells
Adaptive Immunity
Innate Immunity
Neurodegenerative Diseases
Organelles
Eating
Infection
Research
Neoplasms

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Citar esto

Rey-Jurado, E., Riedel, C. A., González, P. A., Bueno, S. M., & Kalergis, A. M. (2015). Contribution of autophagy to antiviral immunity. FEBS Letters, 589(22), 3461-3470. https://doi.org/10.1016/j.febslet.2015.07.047
Rey-Jurado, Emma ; Riedel, Claudia A. ; González, Pablo A. ; Bueno, Susan M. ; Kalergis, Alexis M. / Contribution of autophagy to antiviral immunity. En: FEBS Letters. 2015 ; Vol. 589, N.º 22. pp. 3461-3470.
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Rey-Jurado, E, Riedel, CA, González, PA, Bueno, SM & Kalergis, AM 2015, 'Contribution of autophagy to antiviral immunity', FEBS Letters, vol. 589, n.º 22, pp. 3461-3470. https://doi.org/10.1016/j.febslet.2015.07.047

Contribution of autophagy to antiviral immunity. / Rey-Jurado, Emma; Riedel, Claudia A.; González, Pablo A.; Bueno, Susan M.; Kalergis, Alexis M.

En: FEBS Letters, Vol. 589, N.º 22, 03.05.2015, p. 3461-3470.

Resultado de la investigación: Article

TY - JOUR

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AU - González, Pablo A.

AU - Bueno, Susan M.

AU - Kalergis, Alexis M.

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AB - Although identified in the 1960's, interest in autophagy has significantly increased in the past decade with notable research efforts oriented at understanding as to how this multi-protein complex operates and is regulated. Autophagy is commonly defined as a "self-eating" process evolved by eukaryotic cells to recycle senescent organelles and expired proteins, which is significantly increased during cellular stress responses. In addition, autophagy can also play important roles during human diseases, such as cancer, neurodegenerative and autoimmune disorders. Furthermore, novel findings suggest that autophagy contributes to the host defense against microbial infections. In this article, we review the role of macroautophagy in antiviral immune responses and discuss molecular mechanisms evolved by viral pathogens to evade this process. A role for autophagy as an effector mechanism used both, by innate and adaptive immunity is also discussed.

KW - Adaptive immunity

KW - Autophagy

KW - Innate immunity

KW - Macroautophagy

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Rey-Jurado E, Riedel CA, González PA, Bueno SM, Kalergis AM. Contribution of autophagy to antiviral immunity. FEBS Letters. 2015 may 3;589(22):3461-3470. https://doi.org/10.1016/j.febslet.2015.07.047