Contraceptive potential of a mifepristone-nomegestrol acetate sequential regimen in women

Horacio B. Croxatto, Ana M. Salvatierra, Blanca Fuentealba, Rebeca Massai

Resultado de la investigación: Article

22 Citas (Scopus)

Resumen

The effectiveness of a sequential regimen consisting of mifepristone, 10 mg/day for 15 days, followed by nomegestrol acetate (NOMA), 5 mg/day for the next 13 days, for inhibiting ovulation and maintaining regular bleeding cycles was assessed in 10 surgically sterilized volunteers who were followed for one pretreatment and three treated cycles. Hormonal determinations in blood and urine, ovarian ultrasonography, bleeding records in all cycles and an endometrial biopsy taken on day 22-25 of the third treatment cycle were used to monitor the effects of treatment. During treatment, 24 monophasic (no sustained progesterone rise above 12 nmol/l) and six biphasic cycles were recorded. Nine follicular ruptures were detected echographically in these 30 treated cycles, five of which occurred in monophasic cycles. All follicular ruptures occurred on days 1-7 of NOMA treatment. Echographic and endocrine features of ovulatory cycles were both present in only four treated cycles (13.3%). Development of a secretory endometrium was achieved in all cases, but it was always irregular. Regular withdrawal bleeding occurred in all subjects and no adverse reactions were recorded. The ovarian and endometrial effects of this regimen justify testing its contraceptive effectiveness in phase 2 clinical trials.

Idioma originalEnglish
Páginas (desde-hasta)3297-3302
Número de páginas6
PublicaciónHuman Reproduction
Volumen13
N.º12
DOI
EstadoPublished - 1998

Huella dactilar

nomegestrol acetate
Mifepristone
Contraceptive Agents
Hemorrhage
Rupture
Therapeutics
Menstrual Cycle
Endometrium
Ovulation
Progesterone
Volunteers
Ultrasonography
Clinical Trials
Urine
Biopsy

ASJC Scopus subject areas

  • Developmental Biology
  • Physiology
  • Obstetrics and Gynaecology
  • Reproductive Medicine
  • Rehabilitation

Citar esto

Croxatto, Horacio B. ; Salvatierra, Ana M. ; Fuentealba, Blanca ; Massai, Rebeca. / Contraceptive potential of a mifepristone-nomegestrol acetate sequential regimen in women. En: Human Reproduction. 1998 ; Vol. 13, N.º 12. pp. 3297-3302.
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abstract = "The effectiveness of a sequential regimen consisting of mifepristone, 10 mg/day for 15 days, followed by nomegestrol acetate (NOMA), 5 mg/day for the next 13 days, for inhibiting ovulation and maintaining regular bleeding cycles was assessed in 10 surgically sterilized volunteers who were followed for one pretreatment and three treated cycles. Hormonal determinations in blood and urine, ovarian ultrasonography, bleeding records in all cycles and an endometrial biopsy taken on day 22-25 of the third treatment cycle were used to monitor the effects of treatment. During treatment, 24 monophasic (no sustained progesterone rise above 12 nmol/l) and six biphasic cycles were recorded. Nine follicular ruptures were detected echographically in these 30 treated cycles, five of which occurred in monophasic cycles. All follicular ruptures occurred on days 1-7 of NOMA treatment. Echographic and endocrine features of ovulatory cycles were both present in only four treated cycles (13.3{\%}). Development of a secretory endometrium was achieved in all cases, but it was always irregular. Regular withdrawal bleeding occurred in all subjects and no adverse reactions were recorded. The ovarian and endometrial effects of this regimen justify testing its contraceptive effectiveness in phase 2 clinical trials.",
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Contraceptive potential of a mifepristone-nomegestrol acetate sequential regimen in women. / Croxatto, Horacio B.; Salvatierra, Ana M.; Fuentealba, Blanca; Massai, Rebeca.

En: Human Reproduction, Vol. 13, N.º 12, 1998, p. 3297-3302.

Resultado de la investigación: Article

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AU - Massai, Rebeca

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