Contraceptive efficacy of emergency contraception with levonorgestrel given before or after ovulation

Gabriela Noé, Horacio B. Croxatto, Ana María Salvatierra, Verónica Reyes, Claudio Villarroel, Carla Muñoz, Gabriela Morales, Anita Retamales

Resultado de la investigación: Article

55 Citas (Scopus)

Resumen

Background: We aimed to evaluate whether emergency contraception with levonorgestrel (LNG-EC) administered after ovulation is equally effective to LNG-EC administered before ovulation. Study design: We studied a cohort of women attending a family planning clinic for EC. From interview, we recorded menstrual history, time of intercourse and of intake of LNG-EC. On the day of intake of LNG-EC and during 5 days' follow-up, blood samples were taken for examination of luteinizing hormone, estradiol and progesterone concentrations, and vaginal ultrasound examinations were done for size of the leading follicle and/or corpus luteum. Thereafter women were not contacted until next menses or pregnancy occurred. Results: Of 388 women attending for LNG-EC, 122 women had intercourse on fertile cycle days according to ultrasound and endocrine findings. At the time of LNG-EC intake, 87 women were in Days -5 to -1 and 35 women were in Day 0 (day of ovulation) or beyond. With the use of the probability of clinical pregnancy reported by Wilcox et al. [N Engl J Med 333 (1995) 1517-1521], expected numbers of pregnancies among the 87 and 35 women were 13 and 7, respectively, while 0 and 6 pregnancies, respectively, occurred. Conclusion: We conclude that LNG-EC prevents pregnancy only when taken before fertilization of the ovum has occurred.

Idioma originalEnglish
Páginas (desde-hasta)414-420
Número de páginas7
PublicaciónContraception
Volumen81
N.º5
DOI
EstadoPublished - may 2010

Huella dactilar

Postcoital Contraception
Levonorgestrel
Contraceptive Agents
Ovulation
Pregnancy
Gynecological Examination
Menstruation
Corpus Luteum
Family Planning Services
Luteinizing Hormone
Fertilization
Progesterone
Ovum
Estradiol
Interviews

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Citar esto

Noé, Gabriela ; Croxatto, Horacio B. ; Salvatierra, Ana María ; Reyes, Verónica ; Villarroel, Claudio ; Muñoz, Carla ; Morales, Gabriela ; Retamales, Anita. / Contraceptive efficacy of emergency contraception with levonorgestrel given before or after ovulation. En: Contraception. 2010 ; Vol. 81, N.º 5. pp. 414-420.
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abstract = "Background: We aimed to evaluate whether emergency contraception with levonorgestrel (LNG-EC) administered after ovulation is equally effective to LNG-EC administered before ovulation. Study design: We studied a cohort of women attending a family planning clinic for EC. From interview, we recorded menstrual history, time of intercourse and of intake of LNG-EC. On the day of intake of LNG-EC and during 5 days' follow-up, blood samples were taken for examination of luteinizing hormone, estradiol and progesterone concentrations, and vaginal ultrasound examinations were done for size of the leading follicle and/or corpus luteum. Thereafter women were not contacted until next menses or pregnancy occurred. Results: Of 388 women attending for LNG-EC, 122 women had intercourse on fertile cycle days according to ultrasound and endocrine findings. At the time of LNG-EC intake, 87 women were in Days -5 to -1 and 35 women were in Day 0 (day of ovulation) or beyond. With the use of the probability of clinical pregnancy reported by Wilcox et al. [N Engl J Med 333 (1995) 1517-1521], expected numbers of pregnancies among the 87 and 35 women were 13 and 7, respectively, while 0 and 6 pregnancies, respectively, occurred. Conclusion: We conclude that LNG-EC prevents pregnancy only when taken before fertilization of the ovum has occurred.",
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Noé, G, Croxatto, HB, Salvatierra, AM, Reyes, V, Villarroel, C, Muñoz, C, Morales, G & Retamales, A 2010, 'Contraceptive efficacy of emergency contraception with levonorgestrel given before or after ovulation', Contraception, vol. 81, n.º 5, pp. 414-420. https://doi.org/10.1016/j.contraception.2009.12.015

Contraceptive efficacy of emergency contraception with levonorgestrel given before or after ovulation. / Noé, Gabriela; Croxatto, Horacio B.; Salvatierra, Ana María; Reyes, Verónica; Villarroel, Claudio; Muñoz, Carla; Morales, Gabriela; Retamales, Anita.

En: Contraception, Vol. 81, N.º 5, 05.2010, p. 414-420.

Resultado de la investigación: Article

TY - JOUR

T1 - Contraceptive efficacy of emergency contraception with levonorgestrel given before or after ovulation

AU - Noé, Gabriela

AU - Croxatto, Horacio B.

AU - Salvatierra, Ana María

AU - Reyes, Verónica

AU - Villarroel, Claudio

AU - Muñoz, Carla

AU - Morales, Gabriela

AU - Retamales, Anita

PY - 2010/5

Y1 - 2010/5

N2 - Background: We aimed to evaluate whether emergency contraception with levonorgestrel (LNG-EC) administered after ovulation is equally effective to LNG-EC administered before ovulation. Study design: We studied a cohort of women attending a family planning clinic for EC. From interview, we recorded menstrual history, time of intercourse and of intake of LNG-EC. On the day of intake of LNG-EC and during 5 days' follow-up, blood samples were taken for examination of luteinizing hormone, estradiol and progesterone concentrations, and vaginal ultrasound examinations were done for size of the leading follicle and/or corpus luteum. Thereafter women were not contacted until next menses or pregnancy occurred. Results: Of 388 women attending for LNG-EC, 122 women had intercourse on fertile cycle days according to ultrasound and endocrine findings. At the time of LNG-EC intake, 87 women were in Days -5 to -1 and 35 women were in Day 0 (day of ovulation) or beyond. With the use of the probability of clinical pregnancy reported by Wilcox et al. [N Engl J Med 333 (1995) 1517-1521], expected numbers of pregnancies among the 87 and 35 women were 13 and 7, respectively, while 0 and 6 pregnancies, respectively, occurred. Conclusion: We conclude that LNG-EC prevents pregnancy only when taken before fertilization of the ovum has occurred.

AB - Background: We aimed to evaluate whether emergency contraception with levonorgestrel (LNG-EC) administered after ovulation is equally effective to LNG-EC administered before ovulation. Study design: We studied a cohort of women attending a family planning clinic for EC. From interview, we recorded menstrual history, time of intercourse and of intake of LNG-EC. On the day of intake of LNG-EC and during 5 days' follow-up, blood samples were taken for examination of luteinizing hormone, estradiol and progesterone concentrations, and vaginal ultrasound examinations were done for size of the leading follicle and/or corpus luteum. Thereafter women were not contacted until next menses or pregnancy occurred. Results: Of 388 women attending for LNG-EC, 122 women had intercourse on fertile cycle days according to ultrasound and endocrine findings. At the time of LNG-EC intake, 87 women were in Days -5 to -1 and 35 women were in Day 0 (day of ovulation) or beyond. With the use of the probability of clinical pregnancy reported by Wilcox et al. [N Engl J Med 333 (1995) 1517-1521], expected numbers of pregnancies among the 87 and 35 women were 13 and 7, respectively, while 0 and 6 pregnancies, respectively, occurred. Conclusion: We conclude that LNG-EC prevents pregnancy only when taken before fertilization of the ovum has occurred.

KW - Contraceptive efficacy

KW - Emergency contraception

KW - Levonorgestrel

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U2 - 10.1016/j.contraception.2009.12.015

DO - 10.1016/j.contraception.2009.12.015

M3 - Article

C2 - 20399948

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SP - 414

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JO - Contraception

JF - Contraception

SN - 0010-7824

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