Contraceptive action of megestrol acetate implants in women

Horacio B. Croxatto, Soledad Díaz, Pablo Atria, Sergio Cheviakoff, Sergio Rosatti, Hernán Oddó

Resultado de la investigación: Article

15 Citas (Scopus)

Resumen

Silastic capsules containing megestrol acetate were implanted under the skin for evaluation as a long-term contraceptive method in women. Inhibition of fertility lasting from 9 to 12 months was obtained after a single implantation of 4 capsules. During this period the pregnancy rate was 9.4 and 6.0 per 100 women-years respectively with 2 types of capsules. Restoration of fertility took place promptly after removal of the implant. Spotting or breakthrough bleeding occurred in 30% of the cycles at the beginning of treatment but decreased gradually thereafter to a rate of 8%. This figure did not increase after replacing the capsules with a new set. The only major complication associated with this treatment was a higher than normal incidence of ectopic pregnancies. It is concluded that these implants at the doses tested in this study can reduce fertility for periods up to 1 year but their acceptability as a contraceptive method in humans is limited mainly by their low effectiveness and the increased medical risk associated with method failures.

Idioma originalEnglish
Páginas (desde-hasta)155-167
Número de páginas13
PublicaciónContraception
Volumen4
N.º3
DOI
EstadoPublished - 1971

Huella dactilar

Megestrol Acetate
Contraceptive Agents
Capsules
Fertility
Metrorrhagia
Contraception
Ectopic Pregnancy
Pregnancy Rate
Skin
Incidence
Therapeutics

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Citar esto

Croxatto, H. B., Díaz, S., Atria, P., Cheviakoff, S., Rosatti, S., & Oddó, H. (1971). Contraceptive action of megestrol acetate implants in women. Contraception, 4(3), 155-167. https://doi.org/10.1016/S0010-7824(71)80002-1
Croxatto, Horacio B. ; Díaz, Soledad ; Atria, Pablo ; Cheviakoff, Sergio ; Rosatti, Sergio ; Oddó, Hernán. / Contraceptive action of megestrol acetate implants in women. En: Contraception. 1971 ; Vol. 4, N.º 3. pp. 155-167.
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abstract = "Silastic capsules containing megestrol acetate were implanted under the skin for evaluation as a long-term contraceptive method in women. Inhibition of fertility lasting from 9 to 12 months was obtained after a single implantation of 4 capsules. During this period the pregnancy rate was 9.4 and 6.0 per 100 women-years respectively with 2 types of capsules. Restoration of fertility took place promptly after removal of the implant. Spotting or breakthrough bleeding occurred in 30{\%} of the cycles at the beginning of treatment but decreased gradually thereafter to a rate of 8{\%}. This figure did not increase after replacing the capsules with a new set. The only major complication associated with this treatment was a higher than normal incidence of ectopic pregnancies. It is concluded that these implants at the doses tested in this study can reduce fertility for periods up to 1 year but their acceptability as a contraceptive method in humans is limited mainly by their low effectiveness and the increased medical risk associated with method failures.",
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Croxatto, HB, Díaz, S, Atria, P, Cheviakoff, S, Rosatti, S & Oddó, H 1971, 'Contraceptive action of megestrol acetate implants in women', Contraception, vol. 4, n.º 3, pp. 155-167. https://doi.org/10.1016/S0010-7824(71)80002-1

Contraceptive action of megestrol acetate implants in women. / Croxatto, Horacio B.; Díaz, Soledad; Atria, Pablo; Cheviakoff, Sergio; Rosatti, Sergio; Oddó, Hernán.

En: Contraception, Vol. 4, N.º 3, 1971, p. 155-167.

Resultado de la investigación: Article

TY - JOUR

T1 - Contraceptive action of megestrol acetate implants in women

AU - Croxatto, Horacio B.

AU - Díaz, Soledad

AU - Atria, Pablo

AU - Cheviakoff, Sergio

AU - Rosatti, Sergio

AU - Oddó, Hernán

PY - 1971

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