Contraception with long-acting subdermal implants. A five-year clinical trial with silastic covered rod implants containing levonorgestrel

Dale N. Robertson, Soledad Diaz, Francisco Alvarez-Sanchez, Pentti Holma, Daniel R. Mishell, Elsimar Coutinho, Vivian Brache, Horacio B. Croxatto, Anibal Paundes, Maria Lacarra, Margarita Pavez, Subir Roy, Ana Rita da Silva, Irving Sivin, Janet Stern

Resultado de la investigación: Contribución a una revistaArtículo

7 Citas (Scopus)

Resumen

A total of 189 women volunteered to accept subdermal implants for contraception. The implants were "covered rods", consisting of a core rod containing equal parts by weight of levonorgestrel and polydimethylsiloxane and sealed inside a thin-walled tube of Silastic tubing with medical adhesive. In one study 78 women used 4 3cm rods (study 07) and in the other 111 women used 6 3cm rods. In 5 years of use there were no pregnancies in either group. Terminations because of menstrual problems were twice as frequent among the 4-rod users than among users of the 6 rods. Menstrual pattern analysis is presented for the two rod regimens and compared with the previously reported patterns for the 6-capsule regimen (NORPLANTR). Long-term in vivo release rates are also presented.

Idioma originalInglés
Páginas (desde-hasta)351-359
Número de páginas9
PublicaciónContraception
Volumen31
N.º4
DOI
EstadoPublicada - abr 1985

Áreas temáticas de ASJC Scopus

  • Medicina reproductiva
  • Ginecología y obstetricia

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    Robertson, D. N., Diaz, S., Alvarez-Sanchez, F., Holma, P., Mishell, D. R., Coutinho, E., Brache, V., Croxatto, H. B., Paundes, A., Lacarra, M., Pavez, M., Roy, S., da Silva, A. R., Sivin, I., & Stern, J. (1985). Contraception with long-acting subdermal implants. A five-year clinical trial with silastic covered rod implants containing levonorgestrel. Contraception, 31(4), 351-359. https://doi.org/10.1016/0010-7824(85)90003-4