Contraception with long-acting subdermal implants. A five-year clinical trial with silastic covered rod implants containing levonorgestrel

Dale N. Robertson, Soledad Diaz, Francisco Alvarez-Sanchez, Pentti Holma, Daniel R. Mishell, Elsimar Coutinho, Vivian Brache, Horacio B. Croxatto, Anibal Paundes, Maria Lacarra, Margarita Pavez, Subir Roy, Ana Rita da Silva, Irving Sivin, Janet Stern

Resultado de la investigación: Article

7 Citas (Scopus)

Resumen

A total of 189 women volunteered to accept subdermal implants for contraception. The implants were "covered rods", consisting of a core rod containing equal parts by weight of levonorgestrel and polydimethylsiloxane and sealed inside a thin-walled tube of Silastic tubing with medical adhesive. In one study 78 women used 4 3cm rods (study 07) and in the other 111 women used 6 3cm rods. In 5 years of use there were no pregnancies in either group. Terminations because of menstrual problems were twice as frequent among the 4-rod users than among users of the 6 rods. Menstrual pattern analysis is presented for the two rod regimens and compared with the previously reported patterns for the 6-capsule regimen (NORPLANTR). Long-term in vivo release rates are also presented.

Idioma originalEnglish
Páginas (desde-hasta)351-359
Número de páginas9
PublicaciónContraception
Volumen31
N.º4
DOI
EstadoPublished - 1 ene 1985

Huella dactilar

Levonorgestrel
Contraception
Clinical Trials
Adhesives
Capsules
Weights and Measures
Pregnancy
baysilon

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Citar esto

Robertson, D. N., Diaz, S., Alvarez-Sanchez, F., Holma, P., Mishell, D. R., Coutinho, E., ... Stern, J. (1985). Contraception with long-acting subdermal implants. A five-year clinical trial with silastic covered rod implants containing levonorgestrel. Contraception, 31(4), 351-359. https://doi.org/10.1016/0010-7824(85)90003-4
Robertson, Dale N. ; Diaz, Soledad ; Alvarez-Sanchez, Francisco ; Holma, Pentti ; Mishell, Daniel R. ; Coutinho, Elsimar ; Brache, Vivian ; Croxatto, Horacio B. ; Paundes, Anibal ; Lacarra, Maria ; Pavez, Margarita ; Roy, Subir ; da Silva, Ana Rita ; Sivin, Irving ; Stern, Janet. / Contraception with long-acting subdermal implants. A five-year clinical trial with silastic covered rod implants containing levonorgestrel. En: Contraception. 1985 ; Vol. 31, N.º 4. pp. 351-359.
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abstract = "A total of 189 women volunteered to accept subdermal implants for contraception. The implants were {"}covered rods{"}, consisting of a core rod containing equal parts by weight of levonorgestrel and polydimethylsiloxane and sealed inside a thin-walled tube of Silastic tubing with medical adhesive. In one study 78 women used 4 3cm rods (study 07) and in the other 111 women used 6 3cm rods. In 5 years of use there were no pregnancies in either group. Terminations because of menstrual problems were twice as frequent among the 4-rod users than among users of the 6 rods. Menstrual pattern analysis is presented for the two rod regimens and compared with the previously reported patterns for the 6-capsule regimen (NORPLANTR). Long-term in vivo release rates are also presented.",
author = "Robertson, {Dale N.} and Soledad Diaz and Francisco Alvarez-Sanchez and Pentti Holma and Mishell, {Daniel R.} and Elsimar Coutinho and Vivian Brache and Croxatto, {Horacio B.} and Anibal Paundes and Maria Lacarra and Margarita Pavez and Subir Roy and {da Silva}, {Ana Rita} and Irving Sivin and Janet Stern",
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Robertson, DN, Diaz, S, Alvarez-Sanchez, F, Holma, P, Mishell, DR, Coutinho, E, Brache, V, Croxatto, HB, Paundes, A, Lacarra, M, Pavez, M, Roy, S, da Silva, AR, Sivin, I & Stern, J 1985, 'Contraception with long-acting subdermal implants. A five-year clinical trial with silastic covered rod implants containing levonorgestrel', Contraception, vol. 31, n.º 4, pp. 351-359. https://doi.org/10.1016/0010-7824(85)90003-4

Contraception with long-acting subdermal implants. A five-year clinical trial with silastic covered rod implants containing levonorgestrel. / Robertson, Dale N.; Diaz, Soledad; Alvarez-Sanchez, Francisco; Holma, Pentti; Mishell, Daniel R.; Coutinho, Elsimar; Brache, Vivian; Croxatto, Horacio B.; Paundes, Anibal; Lacarra, Maria; Pavez, Margarita; Roy, Subir; da Silva, Ana Rita; Sivin, Irving; Stern, Janet.

En: Contraception, Vol. 31, N.º 4, 01.01.1985, p. 351-359.

Resultado de la investigación: Article

TY - JOUR

T1 - Contraception with long-acting subdermal implants. A five-year clinical trial with silastic covered rod implants containing levonorgestrel

AU - Robertson, Dale N.

AU - Diaz, Soledad

AU - Alvarez-Sanchez, Francisco

AU - Holma, Pentti

AU - Mishell, Daniel R.

AU - Coutinho, Elsimar

AU - Brache, Vivian

AU - Croxatto, Horacio B.

AU - Paundes, Anibal

AU - Lacarra, Maria

AU - Pavez, Margarita

AU - Roy, Subir

AU - da Silva, Ana Rita

AU - Sivin, Irving

AU - Stern, Janet

PY - 1985/1/1

Y1 - 1985/1/1

N2 - A total of 189 women volunteered to accept subdermal implants for contraception. The implants were "covered rods", consisting of a core rod containing equal parts by weight of levonorgestrel and polydimethylsiloxane and sealed inside a thin-walled tube of Silastic tubing with medical adhesive. In one study 78 women used 4 3cm rods (study 07) and in the other 111 women used 6 3cm rods. In 5 years of use there were no pregnancies in either group. Terminations because of menstrual problems were twice as frequent among the 4-rod users than among users of the 6 rods. Menstrual pattern analysis is presented for the two rod regimens and compared with the previously reported patterns for the 6-capsule regimen (NORPLANTR). Long-term in vivo release rates are also presented.

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