Contamination with nonessential metals from a solid-waste incinerator correlates with nutritional and immunological stress in prefledgling black kites (Milvus migrans)

Guillermo Blanco, Begoña Jiménez, Oscar Frías, Javier Millan, José A. Dávila

Resultado de la investigación: Article

15 Citas (Scopus)

Resumen

We assessed whether levels of heavy metals in blood have detrimental effects on the health of prefledgling black kites (Milvus migrans) exposed to emissions from a solid waste incinerator near Madrid, central Spain. As health indexes, we considered body mass corrected by structural size as a general indicator of nutritional condition and white blood cell counts (especially the heterophil:lymphocyte ratio) as an indirect measure of immune function. Nutritional condition was positively related to levels of Zn, an essential element with a major role in many physiological pathways, while the opposite trend was found for the essential Cu, the concentration of which tends to increase with decreasing nutritional condition. We found an interaction between Zn and Cd, indicating that high levels of Zn produce smaller effects of Cd on body mass. Potential immunological stress, expressed as an increase in the heterophil:lymphocyte ratio, caused by the toxic Cd increased as levels of Cu decreased. Thus, nestlings with low levels of Cu and poor nutritional condition suffered more immunological stress due to Cd contamination than nestlings with higher levels of Cu. We also found a negative interaction between Zn and Cd, indicating a response of essential Zn to increasing levels of Cd, which may be indicative of the negative effects of Cd on the immune system. These results suggest that the participation of metallothioneins in detoxification and metal regulation may also indirectly enhance the adrenal stress response to contaminants, probably through a competition of Cd and Zn for Zn binding sites on metallothioneins, reducing the ability of Cd to stress the immune system.

Idioma originalEnglish
Páginas (desde-hasta)94-101
Número de páginas8
PublicaciónEnvironmental Research
Volumen94
N.º1
DOI
EstadoPublished - 1 ene 2004

Huella dactilar

Solid Waste
Refuse incinerators
Metallothionein
Solid wastes
solid waste
Immune System
Contamination
Lymphocytes
Immune system
Metals
immune system
nestling
body mass
Poisons
metal
Health
Blood
Heavy Metals
blood
Leukocyte Count

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)

Citar esto

Blanco, Guillermo ; Jiménez, Begoña ; Frías, Oscar ; Millan, Javier ; Dávila, José A. / Contamination with nonessential metals from a solid-waste incinerator correlates with nutritional and immunological stress in prefledgling black kites (Milvus migrans). En: Environmental Research. 2004 ; Vol. 94, N.º 1. pp. 94-101.
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abstract = "We assessed whether levels of heavy metals in blood have detrimental effects on the health of prefledgling black kites (Milvus migrans) exposed to emissions from a solid waste incinerator near Madrid, central Spain. As health indexes, we considered body mass corrected by structural size as a general indicator of nutritional condition and white blood cell counts (especially the heterophil:lymphocyte ratio) as an indirect measure of immune function. Nutritional condition was positively related to levels of Zn, an essential element with a major role in many physiological pathways, while the opposite trend was found for the essential Cu, the concentration of which tends to increase with decreasing nutritional condition. We found an interaction between Zn and Cd, indicating that high levels of Zn produce smaller effects of Cd on body mass. Potential immunological stress, expressed as an increase in the heterophil:lymphocyte ratio, caused by the toxic Cd increased as levels of Cu decreased. Thus, nestlings with low levels of Cu and poor nutritional condition suffered more immunological stress due to Cd contamination than nestlings with higher levels of Cu. We also found a negative interaction between Zn and Cd, indicating a response of essential Zn to increasing levels of Cd, which may be indicative of the negative effects of Cd on the immune system. These results suggest that the participation of metallothioneins in detoxification and metal regulation may also indirectly enhance the adrenal stress response to contaminants, probably through a competition of Cd and Zn for Zn binding sites on metallothioneins, reducing the ability of Cd to stress the immune system.",
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Contamination with nonessential metals from a solid-waste incinerator correlates with nutritional and immunological stress in prefledgling black kites (Milvus migrans). / Blanco, Guillermo; Jiménez, Begoña; Frías, Oscar; Millan, Javier; Dávila, José A.

En: Environmental Research, Vol. 94, N.º 1, 01.01.2004, p. 94-101.

Resultado de la investigación: Article

TY - JOUR

T1 - Contamination with nonessential metals from a solid-waste incinerator correlates with nutritional and immunological stress in prefledgling black kites (Milvus migrans)

AU - Blanco, Guillermo

AU - Jiménez, Begoña

AU - Frías, Oscar

AU - Millan, Javier

AU - Dávila, José A.

PY - 2004/1/1

Y1 - 2004/1/1

N2 - We assessed whether levels of heavy metals in blood have detrimental effects on the health of prefledgling black kites (Milvus migrans) exposed to emissions from a solid waste incinerator near Madrid, central Spain. As health indexes, we considered body mass corrected by structural size as a general indicator of nutritional condition and white blood cell counts (especially the heterophil:lymphocyte ratio) as an indirect measure of immune function. Nutritional condition was positively related to levels of Zn, an essential element with a major role in many physiological pathways, while the opposite trend was found for the essential Cu, the concentration of which tends to increase with decreasing nutritional condition. We found an interaction between Zn and Cd, indicating that high levels of Zn produce smaller effects of Cd on body mass. Potential immunological stress, expressed as an increase in the heterophil:lymphocyte ratio, caused by the toxic Cd increased as levels of Cu decreased. Thus, nestlings with low levels of Cu and poor nutritional condition suffered more immunological stress due to Cd contamination than nestlings with higher levels of Cu. We also found a negative interaction between Zn and Cd, indicating a response of essential Zn to increasing levels of Cd, which may be indicative of the negative effects of Cd on the immune system. These results suggest that the participation of metallothioneins in detoxification and metal regulation may also indirectly enhance the adrenal stress response to contaminants, probably through a competition of Cd and Zn for Zn binding sites on metallothioneins, reducing the ability of Cd to stress the immune system.

AB - We assessed whether levels of heavy metals in blood have detrimental effects on the health of prefledgling black kites (Milvus migrans) exposed to emissions from a solid waste incinerator near Madrid, central Spain. As health indexes, we considered body mass corrected by structural size as a general indicator of nutritional condition and white blood cell counts (especially the heterophil:lymphocyte ratio) as an indirect measure of immune function. Nutritional condition was positively related to levels of Zn, an essential element with a major role in many physiological pathways, while the opposite trend was found for the essential Cu, the concentration of which tends to increase with decreasing nutritional condition. We found an interaction between Zn and Cd, indicating that high levels of Zn produce smaller effects of Cd on body mass. Potential immunological stress, expressed as an increase in the heterophil:lymphocyte ratio, caused by the toxic Cd increased as levels of Cu decreased. Thus, nestlings with low levels of Cu and poor nutritional condition suffered more immunological stress due to Cd contamination than nestlings with higher levels of Cu. We also found a negative interaction between Zn and Cd, indicating a response of essential Zn to increasing levels of Cd, which may be indicative of the negative effects of Cd on the immune system. These results suggest that the participation of metallothioneins in detoxification and metal regulation may also indirectly enhance the adrenal stress response to contaminants, probably through a competition of Cd and Zn for Zn binding sites on metallothioneins, reducing the ability of Cd to stress the immune system.

KW - Black kites

KW - Body condition

KW - H:L ratio

KW - Heavy metals

KW - Solid-waste incineration

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C2 - 14643291

AN - SCOPUS:0344551942

VL - 94

SP - 94

EP - 101

JO - Environmental Research

JF - Environmental Research

SN - 0013-9351

IS - 1

ER -