Consequences of nongenomic actions of estradiol on pathogenic genital tract response

Paula Solar, Luis Velasquez

Resultado de la investigación: Review article

3 Citas (Scopus)

Resumen

Estradiol is a steroid hormone that regulates the structure and function of the female reproductive system. In addition to its genomic effects, which are mediated by activated nuclear receptors, estradiol elicits a variety of rapid signaling events independently of transcriptional or genomic regulation. These nongenomic actions influence the milieu of the genital tract, which changes the ability of pathogens to infect the genital tract. This review discusses our current knowledge regarding the mechanisms and relevance of nongenomic estradiol signaling in the genital tract that could change the ability of pathogens to invade epithelial cells. PubMed was searched through January 1980 for papers related to estradiol actions in the ovary, fallopian tube, uterus and cervix. The mechanisms conveying these rapid effects consist of a multitude of signaling molecules and include cross-talk with slower transcriptional actions. The nongenomic actions of estradiol that influence the infectious abilities of pathogens occur either directly on the genital tract cells or indirectly by modulating the local and systemic immune systems. Additional in-depth characterization of the response is required before the normal and pathological reproductive functions of the nongenomic estradiol pathway can be targeted for pharmacological intervention.

Idioma originalEnglish
Número de artículo1
PublicaciónJournal of Molecular Signaling
Volumen8
DOI
EstadoPublished - 26 ene 2013

Huella dactilar

Estradiol
Pathogens
Steroid hormones
Fallopian Tubes
Immune system
Conveying
Cytoplasmic and Nuclear Receptors
PubMed
Cervix Uteri
Ovary
Immune System
Epithelial Cells
Steroids
Hormones
Pharmacology
Molecules

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Citar esto

@article{39b840774a5c4651bdc447e0d1cc24c7,
title = "Consequences of nongenomic actions of estradiol on pathogenic genital tract response",
abstract = "Estradiol is a steroid hormone that regulates the structure and function of the female reproductive system. In addition to its genomic effects, which are mediated by activated nuclear receptors, estradiol elicits a variety of rapid signaling events independently of transcriptional or genomic regulation. These nongenomic actions influence the milieu of the genital tract, which changes the ability of pathogens to infect the genital tract. This review discusses our current knowledge regarding the mechanisms and relevance of nongenomic estradiol signaling in the genital tract that could change the ability of pathogens to invade epithelial cells. PubMed was searched through January 1980 for papers related to estradiol actions in the ovary, fallopian tube, uterus and cervix. The mechanisms conveying these rapid effects consist of a multitude of signaling molecules and include cross-talk with slower transcriptional actions. The nongenomic actions of estradiol that influence the infectious abilities of pathogens occur either directly on the genital tract cells or indirectly by modulating the local and systemic immune systems. Additional in-depth characterization of the response is required before the normal and pathological reproductive functions of the nongenomic estradiol pathway can be targeted for pharmacological intervention.",
keywords = "Estradiol, Genital tract, Immune response, Nongenomic, Pathogenesis",
author = "Paula Solar and Luis Velasquez",
year = "2013",
month = "1",
day = "26",
doi = "10.1186/1750-2187-8-1",
language = "English",
volume = "8",
journal = "Journal of Molecular Signaling",
issn = "1750-2187",
publisher = "BioMed Central",

}

Consequences of nongenomic actions of estradiol on pathogenic genital tract response. / Solar, Paula; Velasquez, Luis.

En: Journal of Molecular Signaling, Vol. 8, 1, 26.01.2013.

Resultado de la investigación: Review article

TY - JOUR

T1 - Consequences of nongenomic actions of estradiol on pathogenic genital tract response

AU - Solar, Paula

AU - Velasquez, Luis

PY - 2013/1/26

Y1 - 2013/1/26

N2 - Estradiol is a steroid hormone that regulates the structure and function of the female reproductive system. In addition to its genomic effects, which are mediated by activated nuclear receptors, estradiol elicits a variety of rapid signaling events independently of transcriptional or genomic regulation. These nongenomic actions influence the milieu of the genital tract, which changes the ability of pathogens to infect the genital tract. This review discusses our current knowledge regarding the mechanisms and relevance of nongenomic estradiol signaling in the genital tract that could change the ability of pathogens to invade epithelial cells. PubMed was searched through January 1980 for papers related to estradiol actions in the ovary, fallopian tube, uterus and cervix. The mechanisms conveying these rapid effects consist of a multitude of signaling molecules and include cross-talk with slower transcriptional actions. The nongenomic actions of estradiol that influence the infectious abilities of pathogens occur either directly on the genital tract cells or indirectly by modulating the local and systemic immune systems. Additional in-depth characterization of the response is required before the normal and pathological reproductive functions of the nongenomic estradiol pathway can be targeted for pharmacological intervention.

AB - Estradiol is a steroid hormone that regulates the structure and function of the female reproductive system. In addition to its genomic effects, which are mediated by activated nuclear receptors, estradiol elicits a variety of rapid signaling events independently of transcriptional or genomic regulation. These nongenomic actions influence the milieu of the genital tract, which changes the ability of pathogens to infect the genital tract. This review discusses our current knowledge regarding the mechanisms and relevance of nongenomic estradiol signaling in the genital tract that could change the ability of pathogens to invade epithelial cells. PubMed was searched through January 1980 for papers related to estradiol actions in the ovary, fallopian tube, uterus and cervix. The mechanisms conveying these rapid effects consist of a multitude of signaling molecules and include cross-talk with slower transcriptional actions. The nongenomic actions of estradiol that influence the infectious abilities of pathogens occur either directly on the genital tract cells or indirectly by modulating the local and systemic immune systems. Additional in-depth characterization of the response is required before the normal and pathological reproductive functions of the nongenomic estradiol pathway can be targeted for pharmacological intervention.

KW - Estradiol

KW - Genital tract

KW - Immune response

KW - Nongenomic

KW - Pathogenesis

UR - http://www.scopus.com/inward/record.url?scp=84872815246&partnerID=8YFLogxK

U2 - 10.1186/1750-2187-8-1

DO - 10.1186/1750-2187-8-1

M3 - Review article

C2 - 23351368

AN - SCOPUS:84872815246

VL - 8

JO - Journal of Molecular Signaling

JF - Journal of Molecular Signaling

SN - 1750-2187

M1 - 1

ER -