Connexin43 hemichannels in satellite glial cells, can they influence sensory neuron activity?

Mauricio A. Retamal, Manuel A. Riquelme, Jimmy Stehberg, Julio Alcayaga

Resultado de la investigación: Review article

4 Citas (Scopus)

Resumen

In this review article, we summarize the current insight on the role of Connexin- and Pannexin-based channels as modulators of sensory neurons. The somas of sensory neurons are located in sensory ganglia (i.e., trigeminal and nodose ganglia). It is well known that within sensory ganglia, sensory neurons do not form neither electrical nor chemical synapses. One of the reasons for this is that each soma is surrounded by glial cells, known as satellite glial cells (SGCs). Recent evidence shows that connexin43 (Cx43) hemichannels and probably pannexons located at SGCs have an important role in paracrine communication between glial cells and sensory neurons. This communication may be exerted via the release of bioactive molecules from SGCs and their subsequent action on receptors located at the soma of sensory neurons. The glio-neuronal communication seems to be relevant for the establishment of chronic pain, hyperalgesia and pathologies associated with tissue inflammation. Based on the current literature, it is possible to propose that Cx43 hemichannels expressed in SGCs could be a novel pharmacological target for treating chronic pain, which need to be directly evaluated in future studies.

Idioma originalEnglish
Número de artículo374
PublicaciónFrontiers in Molecular Neuroscience
Volumen10
DOI
EstadoPublished - 16 nov 2017

Huella dactilar

Connexin 43
Sensory Receptor Cells
Neuroglia
Carisoprodol
Sensory Ganglia
Chronic Pain
Paracrine Communication
Nodose Ganglion
Trigeminal Ganglion
Connexins
Hyperalgesia
Synapses
Pharmacology
Pathology
Inflammation

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Citar esto

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title = "Connexin43 hemichannels in satellite glial cells, can they influence sensory neuron activity?",
abstract = "In this review article, we summarize the current insight on the role of Connexin- and Pannexin-based channels as modulators of sensory neurons. The somas of sensory neurons are located in sensory ganglia (i.e., trigeminal and nodose ganglia). It is well known that within sensory ganglia, sensory neurons do not form neither electrical nor chemical synapses. One of the reasons for this is that each soma is surrounded by glial cells, known as satellite glial cells (SGCs). Recent evidence shows that connexin43 (Cx43) hemichannels and probably pannexons located at SGCs have an important role in paracrine communication between glial cells and sensory neurons. This communication may be exerted via the release of bioactive molecules from SGCs and their subsequent action on receptors located at the soma of sensory neurons. The glio-neuronal communication seems to be relevant for the establishment of chronic pain, hyperalgesia and pathologies associated with tissue inflammation. Based on the current literature, it is possible to propose that Cx43 hemichannels expressed in SGCs could be a novel pharmacological target for treating chronic pain, which need to be directly evaluated in future studies.",
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Connexin43 hemichannels in satellite glial cells, can they influence sensory neuron activity? / Retamal, Mauricio A.; Riquelme, Manuel A.; Stehberg, Jimmy; Alcayaga, Julio.

En: Frontiers in Molecular Neuroscience, Vol. 10, 374, 16.11.2017.

Resultado de la investigación: Review article

TY - JOUR

T1 - Connexin43 hemichannels in satellite glial cells, can they influence sensory neuron activity?

AU - Retamal, Mauricio A.

AU - Riquelme, Manuel A.

AU - Stehberg, Jimmy

AU - Alcayaga, Julio

PY - 2017/11/16

Y1 - 2017/11/16

N2 - In this review article, we summarize the current insight on the role of Connexin- and Pannexin-based channels as modulators of sensory neurons. The somas of sensory neurons are located in sensory ganglia (i.e., trigeminal and nodose ganglia). It is well known that within sensory ganglia, sensory neurons do not form neither electrical nor chemical synapses. One of the reasons for this is that each soma is surrounded by glial cells, known as satellite glial cells (SGCs). Recent evidence shows that connexin43 (Cx43) hemichannels and probably pannexons located at SGCs have an important role in paracrine communication between glial cells and sensory neurons. This communication may be exerted via the release of bioactive molecules from SGCs and their subsequent action on receptors located at the soma of sensory neurons. The glio-neuronal communication seems to be relevant for the establishment of chronic pain, hyperalgesia and pathologies associated with tissue inflammation. Based on the current literature, it is possible to propose that Cx43 hemichannels expressed in SGCs could be a novel pharmacological target for treating chronic pain, which need to be directly evaluated in future studies.

AB - In this review article, we summarize the current insight on the role of Connexin- and Pannexin-based channels as modulators of sensory neurons. The somas of sensory neurons are located in sensory ganglia (i.e., trigeminal and nodose ganglia). It is well known that within sensory ganglia, sensory neurons do not form neither electrical nor chemical synapses. One of the reasons for this is that each soma is surrounded by glial cells, known as satellite glial cells (SGCs). Recent evidence shows that connexin43 (Cx43) hemichannels and probably pannexons located at SGCs have an important role in paracrine communication between glial cells and sensory neurons. This communication may be exerted via the release of bioactive molecules from SGCs and their subsequent action on receptors located at the soma of sensory neurons. The glio-neuronal communication seems to be relevant for the establishment of chronic pain, hyperalgesia and pathologies associated with tissue inflammation. Based on the current literature, it is possible to propose that Cx43 hemichannels expressed in SGCs could be a novel pharmacological target for treating chronic pain, which need to be directly evaluated in future studies.

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