Computerised Dynamic Posturography in Premanifest and Manifest individuals with Huntington’s Disease

Alvaro Reyes, Danielle Salomonczyk, Wei Peng Teo, Luis D. Medina, Danielle Bartlett, Eva Pirogovsky-Turk, Pauline Zaenker, Jody Corey Bloom, Roger W. Simmons, Mel Ziman, Paul E. Gilbert, Travis Cruickshank

Resultado de la investigación: Article

Resumen

Evidence from small-scale studies indicates that impairments in postural stability are an early and disabling feature of Huntington’s disease (HD) and may be a useful clinical endpoint for disease modifying trials. Larger studies are needed to confirm these preliminary findings and the suitability of postural stability outcomes as clinical endpoints. Static and dynamic postural stability were evaluated in 54 premanifest HD, 36 manifest HD and 45 healthy individuals using the Sensory Organization Test (SOT) and Limits of Stability (LOS) test. Manifest HD displayed significantly lower scores on all SOT conditions and on the SOT composite score and had more falls than healthy and premanifest HD (p < 0.05). Premanifest and manifest HD demonstrated significantly lower endpoint excursion (p < 0.001), maximum excursion (p ≤ 0.001), and directional control (p ≤ 0.004) values than healthy individuals on the LOS test. Deficits in LOS were found to manifest on the left side of premanifest HD. Significant but low associations were observed between UHDRS-TMS, disease burden score, diagnostic confidence level, SOT conditions and SOT composite score. We confirm here that individuals with premanifest and manifest HD display significant impairments in static and dynamic postural stability. Dynamic posturography assessments should be considered as clinical endpoints for future disease modifying trials.

Idioma originalEnglish
Número de artículo14615
PublicaciónScientific Reports
Volumen8
N.º1
DOI
EstadoPublished - 2 oct 2018

Huella dactilar

Huntington Disease

ASJC Scopus subject areas

  • General

Citar esto

Reyes, A., Salomonczyk, D., Teo, W. P., Medina, L. D., Bartlett, D., Pirogovsky-Turk, E., ... Cruickshank, T. (2018). Computerised Dynamic Posturography in Premanifest and Manifest individuals with Huntington’s Disease. Scientific Reports, 8(1), [14615]. https://doi.org/10.1038/s41598-018-32924-y
Reyes, Alvaro ; Salomonczyk, Danielle ; Teo, Wei Peng ; Medina, Luis D. ; Bartlett, Danielle ; Pirogovsky-Turk, Eva ; Zaenker, Pauline ; Bloom, Jody Corey ; Simmons, Roger W. ; Ziman, Mel ; Gilbert, Paul E. ; Cruickshank, Travis. / Computerised Dynamic Posturography in Premanifest and Manifest individuals with Huntington’s Disease. En: Scientific Reports. 2018 ; Vol. 8, N.º 1.
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abstract = "Evidence from small-scale studies indicates that impairments in postural stability are an early and disabling feature of Huntington’s disease (HD) and may be a useful clinical endpoint for disease modifying trials. Larger studies are needed to confirm these preliminary findings and the suitability of postural stability outcomes as clinical endpoints. Static and dynamic postural stability were evaluated in 54 premanifest HD, 36 manifest HD and 45 healthy individuals using the Sensory Organization Test (SOT) and Limits of Stability (LOS) test. Manifest HD displayed significantly lower scores on all SOT conditions and on the SOT composite score and had more falls than healthy and premanifest HD (p < 0.05). Premanifest and manifest HD demonstrated significantly lower endpoint excursion (p < 0.001), maximum excursion (p ≤ 0.001), and directional control (p ≤ 0.004) values than healthy individuals on the LOS test. Deficits in LOS were found to manifest on the left side of premanifest HD. Significant but low associations were observed between UHDRS-TMS, disease burden score, diagnostic confidence level, SOT conditions and SOT composite score. We confirm here that individuals with premanifest and manifest HD display significant impairments in static and dynamic postural stability. Dynamic posturography assessments should be considered as clinical endpoints for future disease modifying trials.",
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Reyes, A, Salomonczyk, D, Teo, WP, Medina, LD, Bartlett, D, Pirogovsky-Turk, E, Zaenker, P, Bloom, JC, Simmons, RW, Ziman, M, Gilbert, PE & Cruickshank, T 2018, 'Computerised Dynamic Posturography in Premanifest and Manifest individuals with Huntington’s Disease', Scientific Reports, vol. 8, n.º 1, 14615. https://doi.org/10.1038/s41598-018-32924-y

Computerised Dynamic Posturography in Premanifest and Manifest individuals with Huntington’s Disease. / Reyes, Alvaro; Salomonczyk, Danielle; Teo, Wei Peng; Medina, Luis D.; Bartlett, Danielle; Pirogovsky-Turk, Eva; Zaenker, Pauline; Bloom, Jody Corey; Simmons, Roger W.; Ziman, Mel; Gilbert, Paul E.; Cruickshank, Travis.

En: Scientific Reports, Vol. 8, N.º 1, 14615, 02.10.2018.

Resultado de la investigación: Article

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AU - Gilbert, Paul E.

AU - Cruickshank, Travis

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