Comprehensive insights into the understanding of hypoxia in ameloblastoma

Ronell Bologna-Molina, Lauren Schuch, Sven Eric Niklander

Producción científica: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

Resumen

Hypoxia is characterized by a disparity between supply and demand of oxygen. The association between hypoxia and head and neck tumors is a topic of significant interest. Tumors frequently encounter areas with inadequate oxygen supply, resulting in a hypoxic microenvironment. Ameloblastoma is one of the most common benign odontogenic tumors of the maxillofacial region. It is a slow-growing but locally invasive tumor with a high recurrence rate. The literature has demonstrated the correlation between hypoxia and ameloblastoma, revealing a discernible link between the heightened expression of hypoxic markers in low oxygen conditions. This association is intricately tied to the tumoral potential for invasion, progression, and malignant transformation. Hypoxia profoundly influences the molecular and cellular landscape within ameloblastic lesions. The present review sheds light on the mechanisms, implications, and emerging perspectives in understanding this intriguing association to clarify the dynamic relationship between hypoxia and ameloblastoma.

Idioma originalInglés
Páginas (desde-hasta)983-989
Número de páginas7
PublicaciónHistology and Histopathology
Volumen39
N.º8
DOI
EstadoPublicada - 1 ago. 2024

Áreas temáticas de ASJC Scopus

  • Patología y medicina forense
  • Histología

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