Resumen
Bis(morpholyldithiocarbamato)copper(II), Cu(MorDTC)2, has been studied as a scavenger of the superoxide anion, a reactive radical that can cause very negative effects in vivo. The scavenging takes place through a superoxide dismutase (SOD)-like process. The copper(II) compound has a poor solubility in water. The interaction of Cu(MorDTC)2 with β-cyclodextrin (β-CD) and its dimethyl derivative (dmβ-CD) was studied, resulting in an increase by one order in water solubility and the SOD-like activity of Cu(MorDTC)2. The inclusion constants were determined spectrophotometrically at 435 nm and 300 K. For β-CD, the values of log K11 = 3.96 (± 0.01) and log K21 = 7.47 (± 0.04) were obtained. With dmβ-CD, log K11 = 3.73 (± 0.08) and log K21 = 6.30 (± 0.01) were the values achieved.
| Idioma original | English |
|---|---|
| Páginas (desde-hasta) | 171-175 |
| Número de páginas | 5 |
| Publicación | Supramolecular Chemistry |
| Volumen | 15 |
| N.º | 3 |
| DOI | |
| Estado | Published - abr 2003 |
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- Chemistry(all)
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Complexation of bis(morpholyldithiocarbamato)copper(II), a superoxide scavenger, in β-cyclodextrins. / Martín, Rudy; Fragoso, Alex; Cao, Roberto.
En: Supramolecular Chemistry, Vol. 15, N.º 3, 04.2003, p. 171-175.Resultado de la investigación: Article
TY - JOUR
T1 - Complexation of bis(morpholyldithiocarbamato)copper(II), a superoxide scavenger, in β-cyclodextrins
AU - Martín, Rudy
AU - Fragoso, Alex
AU - Cao, Roberto
PY - 2003/4
Y1 - 2003/4
N2 - Bis(morpholyldithiocarbamato)copper(II), Cu(MorDTC)2, has been studied as a scavenger of the superoxide anion, a reactive radical that can cause very negative effects in vivo. The scavenging takes place through a superoxide dismutase (SOD)-like process. The copper(II) compound has a poor solubility in water. The interaction of Cu(MorDTC)2 with β-cyclodextrin (β-CD) and its dimethyl derivative (dmβ-CD) was studied, resulting in an increase by one order in water solubility and the SOD-like activity of Cu(MorDTC)2. The inclusion constants were determined spectrophotometrically at 435 nm and 300 K. For β-CD, the values of log K11 = 3.96 (± 0.01) and log K21 = 7.47 (± 0.04) were obtained. With dmβ-CD, log K11 = 3.73 (± 0.08) and log K21 = 6.30 (± 0.01) were the values achieved.
AB - Bis(morpholyldithiocarbamato)copper(II), Cu(MorDTC)2, has been studied as a scavenger of the superoxide anion, a reactive radical that can cause very negative effects in vivo. The scavenging takes place through a superoxide dismutase (SOD)-like process. The copper(II) compound has a poor solubility in water. The interaction of Cu(MorDTC)2 with β-cyclodextrin (β-CD) and its dimethyl derivative (dmβ-CD) was studied, resulting in an increase by one order in water solubility and the SOD-like activity of Cu(MorDTC)2. The inclusion constants were determined spectrophotometrically at 435 nm and 300 K. For β-CD, the values of log K11 = 3.96 (± 0.01) and log K21 = 7.47 (± 0.04) were obtained. With dmβ-CD, log K11 = 3.73 (± 0.08) and log K21 = 6.30 (± 0.01) were the values achieved.
KW - Copper(II)
KW - Cyclodextrin
KW - Dithiocarbamate
KW - Inclusion complex
KW - SOD-like activity
UR - http://www.scopus.com/inward/record.url?scp=0038755997&partnerID=8YFLogxK
U2 - 10.1080/1061027031000078266
DO - 10.1080/1061027031000078266
M3 - Article
AN - SCOPUS:0038755997
VL - 15
SP - 171
EP - 175
JO - Supramolecular Chemistry
JF - Supramolecular Chemistry
SN - 1061-0278
IS - 3
ER -