Complexation of bis(morpholyldithiocarbamato)copper(II), a superoxide scavenger, in β-cyclodextrins

Rudy Martín, Alex Fragoso, Roberto Cao

Resultado de la investigación: Article

13 Citas (Scopus)

Resumen

Bis(morpholyldithiocarbamato)copper(II), Cu(MorDTC)2, has been studied as a scavenger of the superoxide anion, a reactive radical that can cause very negative effects in vivo. The scavenging takes place through a superoxide dismutase (SOD)-like process. The copper(II) compound has a poor solubility in water. The interaction of Cu(MorDTC)2 with β-cyclodextrin (β-CD) and its dimethyl derivative (dmβ-CD) was studied, resulting in an increase by one order in water solubility and the SOD-like activity of Cu(MorDTC)2. The inclusion constants were determined spectrophotometrically at 435 nm and 300 K. For β-CD, the values of log K11 = 3.96 (± 0.01) and log K21 = 7.47 (± 0.04) were obtained. With dmβ-CD, log K11 = 3.73 (± 0.08) and log K21 = 6.30 (± 0.01) were the values achieved.

Idioma originalEnglish
Páginas (desde-hasta)171-175
Número de páginas5
PublicaciónSupramolecular Chemistry
Volumen15
N.º3
DOI
EstadoPublished - abr 2003

Huella dactilar

Cyclodextrins
Complexation
Superoxides
Superoxide Dismutase
Copper
Solubility
Copper compounds
Water
Scavenging
Derivatives

ASJC Scopus subject areas

  • Chemistry(all)

Citar esto

Martín, Rudy ; Fragoso, Alex ; Cao, Roberto. / Complexation of bis(morpholyldithiocarbamato)copper(II), a superoxide scavenger, in β-cyclodextrins. En: Supramolecular Chemistry. 2003 ; Vol. 15, N.º 3. pp. 171-175.
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Complexation of bis(morpholyldithiocarbamato)copper(II), a superoxide scavenger, in β-cyclodextrins. / Martín, Rudy; Fragoso, Alex; Cao, Roberto.

En: Supramolecular Chemistry, Vol. 15, N.º 3, 04.2003, p. 171-175.

Resultado de la investigación: Article

TY - JOUR

T1 - Complexation of bis(morpholyldithiocarbamato)copper(II), a superoxide scavenger, in β-cyclodextrins

AU - Martín, Rudy

AU - Fragoso, Alex

AU - Cao, Roberto

PY - 2003/4

Y1 - 2003/4

N2 - Bis(morpholyldithiocarbamato)copper(II), Cu(MorDTC)2, has been studied as a scavenger of the superoxide anion, a reactive radical that can cause very negative effects in vivo. The scavenging takes place through a superoxide dismutase (SOD)-like process. The copper(II) compound has a poor solubility in water. The interaction of Cu(MorDTC)2 with β-cyclodextrin (β-CD) and its dimethyl derivative (dmβ-CD) was studied, resulting in an increase by one order in water solubility and the SOD-like activity of Cu(MorDTC)2. The inclusion constants were determined spectrophotometrically at 435 nm and 300 K. For β-CD, the values of log K11 = 3.96 (± 0.01) and log K21 = 7.47 (± 0.04) were obtained. With dmβ-CD, log K11 = 3.73 (± 0.08) and log K21 = 6.30 (± 0.01) were the values achieved.

AB - Bis(morpholyldithiocarbamato)copper(II), Cu(MorDTC)2, has been studied as a scavenger of the superoxide anion, a reactive radical that can cause very negative effects in vivo. The scavenging takes place through a superoxide dismutase (SOD)-like process. The copper(II) compound has a poor solubility in water. The interaction of Cu(MorDTC)2 with β-cyclodextrin (β-CD) and its dimethyl derivative (dmβ-CD) was studied, resulting in an increase by one order in water solubility and the SOD-like activity of Cu(MorDTC)2. The inclusion constants were determined spectrophotometrically at 435 nm and 300 K. For β-CD, the values of log K11 = 3.96 (± 0.01) and log K21 = 7.47 (± 0.04) were obtained. With dmβ-CD, log K11 = 3.73 (± 0.08) and log K21 = 6.30 (± 0.01) were the values achieved.

KW - Copper(II)

KW - Cyclodextrin

KW - Dithiocarbamate

KW - Inclusion complex

KW - SOD-like activity

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