Complexation of bis(morpholyldithiocarbamato)copper(II), a superoxide scavenger, in β-cyclodextrins

Rudy Martín; Alex Fragoso; Roberto Cao

doi:10.1080/1061027031000078266

Complexation of bis(morpholyldithiocarbamato)copper(II), a superoxide scavenger, in β-cyclodextrins

Rudy Martín, Alex Fragoso, Roberto Cao

Facultad Ciencias Exactas

Resultado de la investigación: Contribución a una revista › Artículo

13 Citas (Scopus)

Resumen

Bis(morpholyldithiocarbamato)copper(II), Cu(MorDTC)₂, has been studied as a scavenger of the superoxide anion, a reactive radical that can cause very negative effects in vivo. The scavenging takes place through a superoxide dismutase (SOD)-like process. The copper(II) compound has a poor solubility in water. The interaction of Cu(MorDTC)₂ with β-cyclodextrin (β-CD) and its dimethyl derivative (dmβ-CD) was studied, resulting in an increase by one order in water solubility and the SOD-like activity of Cu(MorDTC)₂. The inclusion constants were determined spectrophotometrically at 435 nm and 300 K. For β-CD, the values of log K₁₁ = 3.96 (± 0.01) and log K₂₁ = 7.47 (± 0.04) were obtained. With dmβ-CD, log K₁₁ = 3.73 (± 0.08) and log K₂₁ = 6.30 (± 0.01) were the values achieved.

Idioma original	Inglés
Páginas (desde-hasta)	171-175
Número de páginas	5
Publicación	Supramolecular Chemistry
Volumen	15
N.º	3
DOI	https://doi.org/10.1080/1061027031000078266
Estado	Publicada - abr 2003

Áreas temáticas de ASJC Scopus

Química (todo)

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10.1080/1061027031000078266

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Citar esto

Martín, R., Fragoso, A., & Cao, R. (2003). Complexation of bis(morpholyldithiocarbamato)copper(II), a superoxide scavenger, in β-cyclodextrins. Supramolecular Chemistry, 15(3), 171-175. https://doi.org/10.1080/1061027031000078266

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title = "Complexation of bis(morpholyldithiocarbamato)copper(II), a superoxide scavenger, in β-cyclodextrins",

abstract = "Bis(morpholyldithiocarbamato)copper(II), Cu(MorDTC)2, has been studied as a scavenger of the superoxide anion, a reactive radical that can cause very negative effects in vivo. The scavenging takes place through a superoxide dismutase (SOD)-like process. The copper(II) compound has a poor solubility in water. The interaction of Cu(MorDTC)2 with β-cyclodextrin (β-CD) and its dimethyl derivative (dmβ-CD) was studied, resulting in an increase by one order in water solubility and the SOD-like activity of Cu(MorDTC)2. The inclusion constants were determined spectrophotometrically at 435 nm and 300 K. For β-CD, the values of log K11 = 3.96 (± 0.01) and log K21 = 7.47 (± 0.04) were obtained. With dmβ-CD, log K11 = 3.73 (± 0.08) and log K21 = 6.30 (± 0.01) were the values achieved.",

keywords = "Copper(II), Cyclodextrin, Dithiocarbamate, Inclusion complex, SOD-like activity",

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AU - Martín, Rudy

AU - Fragoso, Alex

AU - Cao, Roberto

PY - 2003/4

Y1 - 2003/4

N2 - Bis(morpholyldithiocarbamato)copper(II), Cu(MorDTC)2, has been studied as a scavenger of the superoxide anion, a reactive radical that can cause very negative effects in vivo. The scavenging takes place through a superoxide dismutase (SOD)-like process. The copper(II) compound has a poor solubility in water. The interaction of Cu(MorDTC)2 with β-cyclodextrin (β-CD) and its dimethyl derivative (dmβ-CD) was studied, resulting in an increase by one order in water solubility and the SOD-like activity of Cu(MorDTC)2. The inclusion constants were determined spectrophotometrically at 435 nm and 300 K. For β-CD, the values of log K11 = 3.96 (± 0.01) and log K21 = 7.47 (± 0.04) were obtained. With dmβ-CD, log K11 = 3.73 (± 0.08) and log K21 = 6.30 (± 0.01) were the values achieved.

AB - Bis(morpholyldithiocarbamato)copper(II), Cu(MorDTC)2, has been studied as a scavenger of the superoxide anion, a reactive radical that can cause very negative effects in vivo. The scavenging takes place through a superoxide dismutase (SOD)-like process. The copper(II) compound has a poor solubility in water. The interaction of Cu(MorDTC)2 with β-cyclodextrin (β-CD) and its dimethyl derivative (dmβ-CD) was studied, resulting in an increase by one order in water solubility and the SOD-like activity of Cu(MorDTC)2. The inclusion constants were determined spectrophotometrically at 435 nm and 300 K. For β-CD, the values of log K11 = 3.96 (± 0.01) and log K21 = 7.47 (± 0.04) were obtained. With dmβ-CD, log K11 = 3.73 (± 0.08) and log K21 = 6.30 (± 0.01) were the values achieved.

KW - Copper(II)

KW - Cyclodextrin

KW - Dithiocarbamate

KW - Inclusion complex

KW - SOD-like activity

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