Combinatorial organization of the transcriptional regulatory machinery in biological control and cancer

Gary S. Stein, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, Amjad Javed, Martin Montecino, Sayyed K. Zaidi, Daniel W. Young, Je Yong Choi, Jitesh Pratap

Resultado de la investigación: Contribución a una revistaArtículo de revisión

10 Citas (Scopus)

Resumen

The architecturally associated subnuclear organization of nucleic acids and cognate regulatory factors suggests functional interrelationships between nuclear structure and gene expression. Mechanisms that contribute to the spatial distribution of transcription factors within the three dimensional context of nuclear architecture control the sorting and integration of regulatory information as well as the combinatorial assembly, organization and activities of transcriptional machinery at scaffold-associated subnuclear sites that support gene expression. During the past several years our laboratory has been addressing intranuclear trafficking mechanisms that direct transcription factors to transcriptionally active nuclear microenvironments. We are pursuing these studies using the AML/Runx/Cbfa transcription factors that govern hematopoietic and bone-specific transcription as a paradigm. Our objective is to gain insight into linkage of intranuclear organization of genes, transcripts, and regulatory proteins with fidelity of biological control and contributions of aberrant nuclear structure/function relationships to the onset and progression of tumorigenesis.

Idioma originalInglés
Páginas (desde-hasta)136-154
Número de páginas19
PublicaciónAdvances in Enzyme Regulation
Volumen45
N.º1
DOI
EstadoPublicada - 1 ene 2005

Áreas temáticas de ASJC Scopus

  • Medicina molecular
  • Biología molecular
  • Genética
  • Investigación sobre el cáncer

Huella Profundice en los temas de investigación de 'Combinatorial organization of the transcriptional regulatory machinery in biological control and cancer'. En conjunto forman una huella única.

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    Stein, G. S., Lian, J. B., Stein, J. L., Van Wijnen, A. J., Javed, A., Montecino, M., Zaidi, S. K., Young, D. W., Choi, J. Y., & Pratap, J. (2005). Combinatorial organization of the transcriptional regulatory machinery in biological control and cancer. Advances in Enzyme Regulation, 45(1), 136-154. https://doi.org/10.1016/j.advenzreg.2005.02.009