@article{49de98246e0a42c58eca94d9e5707749,
title = "CLPFFD-PEG functionalized NIR-absorbing hollow gold nanospheres and gold nanorods inhibit β-amyloid aggregation",
abstract = "Gold nanoparticles with specific optical properties in combination with the CLPFFD peptide that exhibits selectivity for β-amyloid (Aβ) aggregates are promising photothermal absorbers for application in Alzheimer's disease therapy. We report on hollow gold nanospheres (HAuNS) and gold nanorods (AuNR), which exhibit strong plasmonic near infrared (NIR) absorbance in the optical window of biological tissue and which are functionalized with CLPFFD in two different ways. Therefore the peptide was either directly bound to the particle surface or indirectly to a particle-protecting polyethylene glycol (PEG) ligand shell, thereby reducing the CLPFFD density on the surfaces of both types of particles. Fully PEGylated particles were used for comparison. The effects on cell viability and the fundamental suitability of the HAuNS and AuNR conjugates as photothermal absorbers to inhibit Aβ-fibrillation are analysed in vitro. The positive influence of the use of PEG ligands on the reduced cytotoxicity of the conjugates and on the Aβ-disaggregation is discussed.",
author = "J. Ruff and N. Hassan and F. Morales-Zavala and J. Steitz and E. Araya and Kogan, {M. J.} and U. Simon",
note = "Funding Information: We thank R. Liffmann for SERS measurements, C. Kl{\"o}ser for IR measurements and B. Hahn for help with experimental work at the Institute of Inorganic Chemistry, RWTH Aachen University. This research was part of the project {\textquoteleft}{\textquoteleft}ForSaTum{\textquoteright}{\textquoteright}, co-funded by the European Union (European Regional Development Fund – Investing in your future) and the German federal state North Rhine-Westphalia (NRW) (F{\"o}rderkennzeichen 005-0908-0112). Furthermore, financial support from the Deutsche Forschungs-gemeinschaft is gratefully acknowledged. MK is grateful to Fondap 15130011, Fondecyt 1130425 and 1170929 (Chile). EA is grateful to Fondecyt 11130494 and 1309/16R UNAB. N. H. acknowledges funding from Programa Fondecyt Postdoctoral number 3140489. F. M. acknowledges funding from Beca Conicyt de doctorado Folio 21120617. Funding Information: This research was part of the project {"}ForSaTum{"}, co-funded by the European Union (European Regional Development Fund-Investing in your future) and the German federal state North Rhine-Westphalia (NRW) (Frderkennzeichen 005-0908-0112). Furthermore, financial support from the Deutsche Forschungsgemeinschaft is gratefully acknowledged. MK is grateful to Fondap 15130011, Fondecyt 1130425 and 1170929 (Chile). EA is grateful to Fondecyt 11130494 and 1309/16R UNAB. N. H. acknowledges funding from Programa Fondecyt Postdoctoral number 3140489. F. M. acknowledges funding from Beca Conicyt de doctorado Folio 21120617. Publisher Copyright: {\textcopyright} 2018 The Royal Society of Chemistry.",
year = "2018",
month = jan,
day = "1",
doi = "10.1039/c8tb00655e",
language = "English",
volume = "6",
pages = "2432--2443",
journal = "Journal of Materials Chemistry B",
issn = "2050-7518",
publisher = "Royal Society of Chemistry",
number = "16",
}