Clostridioides (Clostridium) difficile infection

Current and alternative therapeutic strategies

Resultado de la investigación: Review article

2 Citas (Scopus)

Resumen

Clostridioides difficile (C. difficile) has become a pathogen of worldwide importance considering that epidemic strains are disseminated in hospitals of several countries, where community-acquired infections act as a constant source of new C. difficile strains into hospitals. Despite the advances in the treatment of infections, more effective therapies against C. difficile are needed but, at the same time, these therapies should be less harmful to the resident gastrointestinal microbiota. The purpose of this review is to present a description of issues associated to C. difficile infection, a summary of current therapies and those in developmental stage, and a discussion of potential combinations that may lead to an increased efficacy of C. difficile infection treatment.

Idioma originalEnglish
Páginas (desde-hasta)469-482
Número de páginas14
PublicaciónFuture Microbiology
Volumen13
N.º4
DOI
EstadoPublished - 1 mar 2018

Huella dactilar

Clostridium Infections
Clostridium difficile
Infection
Community-Acquired Infections
Therapeutics

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Citar esto

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title = "Clostridioides (Clostridium) difficile infection: Current and alternative therapeutic strategies",
abstract = "Clostridioides difficile (C. difficile) has become a pathogen of worldwide importance considering that epidemic strains are disseminated in hospitals of several countries, where community-acquired infections act as a constant source of new C. difficile strains into hospitals. Despite the advances in the treatment of infections, more effective therapies against C. difficile are needed but, at the same time, these therapies should be less harmful to the resident gastrointestinal microbiota. The purpose of this review is to present a description of issues associated to C. difficile infection, a summary of current therapies and those in developmental stage, and a discussion of potential combinations that may lead to an increased efficacy of C. difficile infection treatment.",
keywords = "Clostridioides difficile infection, Clostridioides difficile treatment, Clostridium",
author = "Fernando Gil and Calder{\'o}n, {Iv{\'a}n L.} and Fuentes, {Juan A.} and Daniel Paredes-Sabja",
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T1 - Clostridioides (Clostridium) difficile infection

T2 - Current and alternative therapeutic strategies

AU - Gil, Fernando

AU - Calderón, Iván L.

AU - Fuentes, Juan A.

AU - Paredes-Sabja, Daniel

PY - 2018/3/1

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AB - Clostridioides difficile (C. difficile) has become a pathogen of worldwide importance considering that epidemic strains are disseminated in hospitals of several countries, where community-acquired infections act as a constant source of new C. difficile strains into hospitals. Despite the advances in the treatment of infections, more effective therapies against C. difficile are needed but, at the same time, these therapies should be less harmful to the resident gastrointestinal microbiota. The purpose of this review is to present a description of issues associated to C. difficile infection, a summary of current therapies and those in developmental stage, and a discussion of potential combinations that may lead to an increased efficacy of C. difficile infection treatment.

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KW - Clostridioides difficile treatment

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