TY - JOUR
T1 - Clinical assessment of treatments for prolonged bleeding in users of norplantR implants
AU - Dĺaz, Soledad
AU - Croxatto, Horacio B.
AU - Pavez, Margarita
AU - Belhadj, Hedia
AU - Stern, Janet
AU - Sivin, Irving
PY - 1990/1/1
Y1 - 1990/1/1
N2 - The effectiveness of three drugs in controlling prolonged bleeding in the first year of NORPLANTR implants use was tested. The drugs were levonorgestrel (L-Ng, 0.03 mg twice a day for 20 days), ethinylestradiol (EE, 0.05 mg per day for 20 days) and ibuprofen (Ib, 800 mg three times a day for 5 days) and were given orally. A control group received a placebo (PL, one pill of lactose for 20 days). Treatment should start each time a woman experienced eight consecutive days of bleeding or spotting. The 183 volunteers were not aware of the drug administered. A daily record of bleeding and spotting and of treatment intake was maintained. One-hundred-forty women completed the study period; 60 never used the prescribed treatment. Women treated with the three test drugs had significantly fewer bleeding and spotting days during the treated month and also throughout the study year than women using the placebo. The mean number of bleeding plus spotting days per actually treated subject in the first year was 77, 94, 101 and 129 days for the EE, Ib, L-Ng and PL groups, respectively. The administration of EE might help in the management of prolonged bleeding during the first year of NORPLANTR implants use.
AB - The effectiveness of three drugs in controlling prolonged bleeding in the first year of NORPLANTR implants use was tested. The drugs were levonorgestrel (L-Ng, 0.03 mg twice a day for 20 days), ethinylestradiol (EE, 0.05 mg per day for 20 days) and ibuprofen (Ib, 800 mg three times a day for 5 days) and were given orally. A control group received a placebo (PL, one pill of lactose for 20 days). Treatment should start each time a woman experienced eight consecutive days of bleeding or spotting. The 183 volunteers were not aware of the drug administered. A daily record of bleeding and spotting and of treatment intake was maintained. One-hundred-forty women completed the study period; 60 never used the prescribed treatment. Women treated with the three test drugs had significantly fewer bleeding and spotting days during the treated month and also throughout the study year than women using the placebo. The mean number of bleeding plus spotting days per actually treated subject in the first year was 77, 94, 101 and 129 days for the EE, Ib, L-Ng and PL groups, respectively. The administration of EE might help in the management of prolonged bleeding during the first year of NORPLANTR implants use.
UR - http://www.scopus.com/inward/record.url?scp=0025286256&partnerID=8YFLogxK
U2 - 10.1016/0010-7824(90)90094-C
DO - 10.1016/0010-7824(90)90094-C
M3 - Article
C2 - 2117517
AN - SCOPUS:0025286256
VL - 42
SP - 97
EP - 109
JO - Contraception
JF - Contraception
SN - 0010-7824
IS - 1
ER -