Clearance of levonorgestrel from the circulation following removal of NORPLANTR subdermal implants

H. B. Croxatto, S. Díaz, M. Pavez, H. Cárdenas, M. Larsson, E. D B Johansson

Resultado de la investigación: Article

24 Citas (Scopus)

Resumen

The disappearance of levonorgestrel from plasma after the removal of NORPLANTR subdermal implants was studied in 12 women who had been treated from 5.5 to 78 months. The existence of one or two half-lives for the rate of disappearance was assessed. The influence of body weight, body fat and length of treatment upon levonorgestrel clearance was studied through stepwise regression analysis. It was found that the levonorgestrel decay rate after implant removal can be entirely accounted assuming one half-life of 42 ± 16 h ( x ̄ ± SD; range 13 to 62 h). Stepwise regression analysis showed that levonorgestrel half-life is positively correlated with body weight and not significantly correlated with the length of treatment or body fat. It is concluded that, after long-term administration of levonorgestrel via subdermal implants, the major part of the steroid is cleared from plasma within 96 h and that only trace amounts are detected in the following days.

Idioma originalEnglish
Páginas (desde-hasta)509-523
Número de páginas15
PublicaciónContraception
Volumen38
N.º5
DOI
EstadoPublished - 1988

Huella dactilar

Levonorgestrel
Half-Life
Adipose Tissue
Body Weight
Regression Analysis
Steroids
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynaecology
  • Reproductive Medicine

Citar esto

Croxatto, H. B. ; Díaz, S. ; Pavez, M. ; Cárdenas, H. ; Larsson, M. ; Johansson, E. D B. / Clearance of levonorgestrel from the circulation following removal of NORPLANTR subdermal implants. En: Contraception. 1988 ; Vol. 38, N.º 5. pp. 509-523.
@article{593a75ca3a1c47939b5a7ef477cc7463,
title = "Clearance of levonorgestrel from the circulation following removal of NORPLANTR subdermal implants",
abstract = "The disappearance of levonorgestrel from plasma after the removal of NORPLANTR subdermal implants was studied in 12 women who had been treated from 5.5 to 78 months. The existence of one or two half-lives for the rate of disappearance was assessed. The influence of body weight, body fat and length of treatment upon levonorgestrel clearance was studied through stepwise regression analysis. It was found that the levonorgestrel decay rate after implant removal can be entirely accounted assuming one half-life of 42 ± 16 h ( x ̄ ± SD; range 13 to 62 h). Stepwise regression analysis showed that levonorgestrel half-life is positively correlated with body weight and not significantly correlated with the length of treatment or body fat. It is concluded that, after long-term administration of levonorgestrel via subdermal implants, the major part of the steroid is cleared from plasma within 96 h and that only trace amounts are detected in the following days.",
author = "Croxatto, {H. B.} and S. D{\'i}az and M. Pavez and H. C{\'a}rdenas and M. Larsson and Johansson, {E. D B}",
year = "1988",
doi = "10.1016/0010-7824(88)90155-2",
language = "English",
volume = "38",
pages = "509--523",
journal = "Contraception",
issn = "0010-7824",
publisher = "Elsevier USA",
number = "5",

}

Clearance of levonorgestrel from the circulation following removal of NORPLANTR subdermal implants. / Croxatto, H. B.; Díaz, S.; Pavez, M.; Cárdenas, H.; Larsson, M.; Johansson, E. D B.

En: Contraception, Vol. 38, N.º 5, 1988, p. 509-523.

Resultado de la investigación: Article

TY - JOUR

T1 - Clearance of levonorgestrel from the circulation following removal of NORPLANTR subdermal implants

AU - Croxatto, H. B.

AU - Díaz, S.

AU - Pavez, M.

AU - Cárdenas, H.

AU - Larsson, M.

AU - Johansson, E. D B

PY - 1988

Y1 - 1988

N2 - The disappearance of levonorgestrel from plasma after the removal of NORPLANTR subdermal implants was studied in 12 women who had been treated from 5.5 to 78 months. The existence of one or two half-lives for the rate of disappearance was assessed. The influence of body weight, body fat and length of treatment upon levonorgestrel clearance was studied through stepwise regression analysis. It was found that the levonorgestrel decay rate after implant removal can be entirely accounted assuming one half-life of 42 ± 16 h ( x ̄ ± SD; range 13 to 62 h). Stepwise regression analysis showed that levonorgestrel half-life is positively correlated with body weight and not significantly correlated with the length of treatment or body fat. It is concluded that, after long-term administration of levonorgestrel via subdermal implants, the major part of the steroid is cleared from plasma within 96 h and that only trace amounts are detected in the following days.

AB - The disappearance of levonorgestrel from plasma after the removal of NORPLANTR subdermal implants was studied in 12 women who had been treated from 5.5 to 78 months. The existence of one or two half-lives for the rate of disappearance was assessed. The influence of body weight, body fat and length of treatment upon levonorgestrel clearance was studied through stepwise regression analysis. It was found that the levonorgestrel decay rate after implant removal can be entirely accounted assuming one half-life of 42 ± 16 h ( x ̄ ± SD; range 13 to 62 h). Stepwise regression analysis showed that levonorgestrel half-life is positively correlated with body weight and not significantly correlated with the length of treatment or body fat. It is concluded that, after long-term administration of levonorgestrel via subdermal implants, the major part of the steroid is cleared from plasma within 96 h and that only trace amounts are detected in the following days.

UR - http://www.scopus.com/inward/record.url?scp=0023685220&partnerID=8YFLogxK

U2 - 10.1016/0010-7824(88)90155-2

DO - 10.1016/0010-7824(88)90155-2

M3 - Article

VL - 38

SP - 509

EP - 523

JO - Contraception

JF - Contraception

SN - 0010-7824

IS - 5

ER -