Circadian cycle-dependent MeCP2 and brain chromatin changes

Alexia Martínez De Paz, Jose Vicente Sanchez-Mut, Mireia Samitier-Martí, Paolo Petazzi, Mauricio Sáez, Karolina Szczesna, Dori Huertas, Manel Esteller, Juan Ausió

Resultado de la investigación: Contribución a una revistaArtículo

13 Citas (Scopus)

Resumen

Methyl CpG binding protein 2 (MeCP2) is a chromosomal protein of the brain, very abundant especially in neurons, where it plays an important role in the regulation of gene expression. Hence it has the potential to be affected by the mammalian circadian cycle. We performed expression analyses of mice brain frontal cortices obtained at different time points and we found that the levels of MeCP2 are altered circadianly, affecting overall organization of brain chromatin and resulting in a circadian-dependent regulation of well-stablished MeCP2 target genes. Furthermore, this data suggests that alterations of MeCP2 can be responsible for the sleeping disorders arising from pathological stages, such as in autism and Rett syndrome.

Idioma originalInglés
Número de artículoe0123693
PublicaciónPLoS ONE
Volumen10
N.º4
DOI
EstadoPublicada - 13 abr 2015

Áreas temáticas de ASJC Scopus

  • Medicina (todo)
  • Bioquímica, genética y biología molecular (todo)
  • Agricultura y biología (todo)

Huella Profundice en los temas de investigación de 'Circadian cycle-dependent MeCP2 and brain chromatin changes'. En conjunto forman una huella única.

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    De Paz, A. M., Sanchez-Mut, J. V., Samitier-Martí, M., Petazzi, P., Sáez, M., Szczesna, K., Huertas, D., Esteller, M., & Ausió, J. (2015). Circadian cycle-dependent MeCP2 and brain chromatin changes. PLoS ONE, 10(4), [e0123693]. https://doi.org/10.1371/journal.pone.0136470