Circadian cycle-dependent MeCP2 and brain chromatin changes

Alexia Martínez De Paz, Jose Vicente Sanchez-Mut, Mireia Samitier-Martí, Paolo Petazzi, Mauricio Sáez, Karolina Szczesna, Dori Huertas, Manel Esteller, Juan Ausió

Resultado de la investigación: Article

12 Citas (Scopus)

Resumen

Methyl CpG binding protein 2 (MeCP2) is a chromosomal protein of the brain, very abundant especially in neurons, where it plays an important role in the regulation of gene expression. Hence it has the potential to be affected by the mammalian circadian cycle. We performed expression analyses of mice brain frontal cortices obtained at different time points and we found that the levels of MeCP2 are altered circadianly, affecting overall organization of brain chromatin and resulting in a circadian-dependent regulation of well-stablished MeCP2 target genes. Furthermore, this data suggests that alterations of MeCP2 can be responsible for the sleeping disorders arising from pathological stages, such as in autism and Rett syndrome.

Idioma originalEnglish
Número de artículoe0123693
PublicaciónPLoS ONE
Volumen10
N.º4
DOI
EstadoPublished - 13 abr 2015

Huella dactilar

Methyl-CpG-Binding Protein 2
Chromatin
chromatin
binding proteins
Brain
brain
Rett Syndrome
gene expression regulation
Gene Expression Regulation
Frontal Lobe
Autistic Disorder
Gene expression
Neurons
Genes
neurons
mice
Proteins
genes
proteins

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Citar esto

De Paz, A. M., Sanchez-Mut, J. V., Samitier-Martí, M., Petazzi, P., Sáez, M., Szczesna, K., ... Ausió, J. (2015). Circadian cycle-dependent MeCP2 and brain chromatin changes. PLoS ONE, 10(4), [e0123693]. https://doi.org/10.1371/journal.pone.0136470
De Paz, Alexia Martínez ; Sanchez-Mut, Jose Vicente ; Samitier-Martí, Mireia ; Petazzi, Paolo ; Sáez, Mauricio ; Szczesna, Karolina ; Huertas, Dori ; Esteller, Manel ; Ausió, Juan. / Circadian cycle-dependent MeCP2 and brain chromatin changes. En: PLoS ONE. 2015 ; Vol. 10, N.º 4.
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abstract = "Methyl CpG binding protein 2 (MeCP2) is a chromosomal protein of the brain, very abundant especially in neurons, where it plays an important role in the regulation of gene expression. Hence it has the potential to be affected by the mammalian circadian cycle. We performed expression analyses of mice brain frontal cortices obtained at different time points and we found that the levels of MeCP2 are altered circadianly, affecting overall organization of brain chromatin and resulting in a circadian-dependent regulation of well-stablished MeCP2 target genes. Furthermore, this data suggests that alterations of MeCP2 can be responsible for the sleeping disorders arising from pathological stages, such as in autism and Rett syndrome.",
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De Paz, AM, Sanchez-Mut, JV, Samitier-Martí, M, Petazzi, P, Sáez, M, Szczesna, K, Huertas, D, Esteller, M & Ausió, J 2015, 'Circadian cycle-dependent MeCP2 and brain chromatin changes', PLoS ONE, vol. 10, n.º 4, e0123693. https://doi.org/10.1371/journal.pone.0136470

Circadian cycle-dependent MeCP2 and brain chromatin changes. / De Paz, Alexia Martínez; Sanchez-Mut, Jose Vicente; Samitier-Martí, Mireia; Petazzi, Paolo; Sáez, Mauricio; Szczesna, Karolina; Huertas, Dori; Esteller, Manel; Ausió, Juan.

En: PLoS ONE, Vol. 10, N.º 4, e0123693, 13.04.2015.

Resultado de la investigación: Article

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AU - De Paz, Alexia Martínez

AU - Sanchez-Mut, Jose Vicente

AU - Samitier-Martí, Mireia

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AU - Sáez, Mauricio

AU - Szczesna, Karolina

AU - Huertas, Dori

AU - Esteller, Manel

AU - Ausió, Juan

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De Paz AM, Sanchez-Mut JV, Samitier-Martí M, Petazzi P, Sáez M, Szczesna K y otros. Circadian cycle-dependent MeCP2 and brain chromatin changes. PLoS ONE. 2015 abr 13;10(4). e0123693. https://doi.org/10.1371/journal.pone.0136470