1. Chronic pretreatment of rats with oxypertine induced the appearance of spontaneous contractions in the isolated vasa deferentia, with initial hyposensitivity but late hypersensitivity to noradrenaline, without changes in ED50 to dopamine and with enhanced maximal responses to both agonists. 2. These effects are compared to the different profiles induced by chronic pretreatment with haloperidol, imipramine and reserpine.
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