Characterization of MgtC, a virulence factor of Salmonella enterica serovar typhi

Patricio Retamal, Mario Castillo-Ruiz, Guido C. Mora

Resultado de la investigación: Contribución a una revistaArtículo

27 Citas (Scopus)

Resumen

The MgtC is a virulence factor in Salmonella Typhimurium that is required for growth at low-Mg2+ concentrations and intramacrophage survival. This gene is codified in a conserved region of the Salmonella pathogenicity island 3 (SPI-3), and is also present in the chromosome of other Salmonella serovars. In this study we characterized the MgtC factor in S. Typhi, a human specific pathogen, by using mgtC and SPI-3 mutant strains. We found that MgtC is the most important factor codified in the SPI-3 of S. Typhi for growth in low-Mg2+ media and survival within human cells. In addition, by using reporter genes we determined that the low-Mg2+ concentration, acidic media and PhoP regulator induce mgtC expression in S. Typhi. We suggest that MgtC is the most important virulence factor codified in the SPI-3 of S. Typhi.

Idioma originalInglés
Número de artículoe5551
PublicaciónPLoS ONE
Volumen4
N.º5
DOI
EstadoPublicada - 14 may 2009

Áreas temáticas de ASJC Scopus

  • Agricultura y biología (todo)
  • Bioquímica, genética y biología molecular (todo)
  • Medicina (todo)

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