Characterization of MgtC, a virulence factor of Salmonella enterica serovar typhi

Patricio Retamal, Mario Castillo-Ruiz, Guido C. Mora

Resultado de la investigación: Article

27 Citas (Scopus)

Resumen

The MgtC is a virulence factor in Salmonella Typhimurium that is required for growth at low-Mg2+ concentrations and intramacrophage survival. This gene is codified in a conserved region of the Salmonella pathogenicity island 3 (SPI-3), and is also present in the chromosome of other Salmonella serovars. In this study we characterized the MgtC factor in S. Typhi, a human specific pathogen, by using mgtC and SPI-3 mutant strains. We found that MgtC is the most important factor codified in the SPI-3 of S. Typhi for growth in low-Mg2+ media and survival within human cells. In addition, by using reporter genes we determined that the low-Mg2+ concentration, acidic media and PhoP regulator induce mgtC expression in S. Typhi. We suggest that MgtC is the most important virulence factor codified in the SPI-3 of S. Typhi.

Idioma originalEnglish
Número de artículoe5551
PublicaciónPLoS ONE
Volumen4
N.º5
DOI
EstadoPublished - 14 may 2009

Huella dactilar

Salmonella Typhi
Salmonella typhi
Salmonella
pathogenicity islands
Virulence Factors
Genomic Islands
virulence
Genes
Survival
Salmonella typhimurium
Growth
Reporter Genes
reporter genes
Salmonella Typhimurium
Pathogens
Chromosomes
serotypes
chromosomes
mutants
Cells

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Citar esto

Retamal, Patricio ; Castillo-Ruiz, Mario ; Mora, Guido C. / Characterization of MgtC, a virulence factor of Salmonella enterica serovar typhi. En: PLoS ONE. 2009 ; Vol. 4, N.º 5.
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Characterization of MgtC, a virulence factor of Salmonella enterica serovar typhi. / Retamal, Patricio; Castillo-Ruiz, Mario; Mora, Guido C.

En: PLoS ONE, Vol. 4, N.º 5, e5551, 14.05.2009.

Resultado de la investigación: Article

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