TY - JOUR
T1 - Central Role of Transforming Growth Factor Type Beta 1 in Skeletal Muscle Dysfunctions
T2 - An Update on Therapeutic Strategies
AU - Abrigo, Johanna
AU - Simon, Felipe
AU - Cabrera, Daniel
AU - Cordova, Gonzalo
AU - Trollet, Capucine
AU - Cabello-Verrugio, Claudio
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Among the soluble factors that regulate skeletal muscle function, Transforming Growth Factor type Beta 1 (TGF-β1) is one of the most studied. This factor inhibits myogenesis and regeneration by regulating the activity and function of satellite cells (SCs). Indeed, TGF-β has a central role in muscle pathologies in which there is development of fibrosis and/or atrophy of skeletal muscle. Thus, in this review we present the critical and recent antecedents regarding the mechanisms and cellular targets involved in the effects of TGF-β1 in the muscle, in pathological processes such as the inhibition of regeneration, fibrosis and atrophy. In addition, an update on the development of new strategies with therapeutic potential to inhibit the deleterious actions of TGF-β in skeletal muscle is discussed.
AB - Among the soluble factors that regulate skeletal muscle function, Transforming Growth Factor type Beta 1 (TGF-β1) is one of the most studied. This factor inhibits myogenesis and regeneration by regulating the activity and function of satellite cells (SCs). Indeed, TGF-β has a central role in muscle pathologies in which there is development of fibrosis and/or atrophy of skeletal muscle. Thus, in this review we present the critical and recent antecedents regarding the mechanisms and cellular targets involved in the effects of TGF-β1 in the muscle, in pathological processes such as the inhibition of regeneration, fibrosis and atrophy. In addition, an update on the development of new strategies with therapeutic potential to inhibit the deleterious actions of TGF-β in skeletal muscle is discussed.
KW - blocking antibodies
KW - dystrophy
KW - fibrosis
KW - Muscle atrophy
KW - renin angiotensin system
KW - therapy.
UR - http://www.scopus.com/inward/record.url?scp=85054774498&partnerID=8YFLogxK
U2 - 10.2174/1389203718666171117101916
DO - 10.2174/1389203718666171117101916
M3 - Article
C2 - 29150918
AN - SCOPUS:85054774498
SN - 1389-2037
VL - 19
SP - 1189
EP - 1200
JO - Current protein & peptide science
JF - Current protein & peptide science
IS - 12
ER -