Central Role of Transforming Growth Factor Type Beta 1 in Skeletal Muscle Dysfunctions

An Update on Therapeutic Strategies

Johanna Abrigo, Felipe Simon, Daniel Cabrera, Gonzalo Cordova, Capucine Trollet, Claudio Cabello-Verrugio

Resultado de la investigación: Article

3 Citas (Scopus)

Resumen

Among the soluble factors that regulate skeletal muscle function, Transforming Growth Factor type Beta 1 (TGF-β1) is one of the most studied. This factor inhibits myogenesis and regeneration by regulating the activity and function of satellite cells (SCs). Indeed, TGF-β has a central role in muscle pathologies in which there is development of fibrosis and/or atrophy of skeletal muscle. Thus, in this review we present the critical and recent antecedents regarding the mechanisms and cellular targets involved in the effects of TGF-β1 in the muscle, in pathological processes such as the inhibition of regeneration, fibrosis and atrophy. In addition, an update on the development of new strategies with therapeutic potential to inhibit the deleterious actions of TGF-β in skeletal muscle is discussed.

Idioma originalEnglish
Páginas (desde-hasta)1189-1200
Número de páginas12
PublicaciónCurrent protein & peptide science
Volumen19
N.º12
DOI
EstadoPublished - 1 ene 2018

Huella dactilar

Transforming Growth Factors
Transforming Growth Factor beta
Muscle
Skeletal Muscle
Atrophy
Regeneration
Fibrosis
Muscles
Muscle Development
Pathologic Processes
Therapeutics
Pathology
Satellites

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Citar esto

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abstract = "Among the soluble factors that regulate skeletal muscle function, Transforming Growth Factor type Beta 1 (TGF-β1) is one of the most studied. This factor inhibits myogenesis and regeneration by regulating the activity and function of satellite cells (SCs). Indeed, TGF-β has a central role in muscle pathologies in which there is development of fibrosis and/or atrophy of skeletal muscle. Thus, in this review we present the critical and recent antecedents regarding the mechanisms and cellular targets involved in the effects of TGF-β1 in the muscle, in pathological processes such as the inhibition of regeneration, fibrosis and atrophy. In addition, an update on the development of new strategies with therapeutic potential to inhibit the deleterious actions of TGF-β in skeletal muscle is discussed.",
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Central Role of Transforming Growth Factor Type Beta 1 in Skeletal Muscle Dysfunctions : An Update on Therapeutic Strategies. / Abrigo, Johanna; Simon, Felipe; Cabrera, Daniel; Cordova, Gonzalo; Trollet, Capucine; Cabello-Verrugio, Claudio.

En: Current protein & peptide science, Vol. 19, N.º 12, 01.01.2018, p. 1189-1200.

Resultado de la investigación: Article

TY - JOUR

T1 - Central Role of Transforming Growth Factor Type Beta 1 in Skeletal Muscle Dysfunctions

T2 - An Update on Therapeutic Strategies

AU - Abrigo, Johanna

AU - Simon, Felipe

AU - Cabrera, Daniel

AU - Cordova, Gonzalo

AU - Trollet, Capucine

AU - Cabello-Verrugio, Claudio

PY - 2018/1/1

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N2 - Among the soluble factors that regulate skeletal muscle function, Transforming Growth Factor type Beta 1 (TGF-β1) is one of the most studied. This factor inhibits myogenesis and regeneration by regulating the activity and function of satellite cells (SCs). Indeed, TGF-β has a central role in muscle pathologies in which there is development of fibrosis and/or atrophy of skeletal muscle. Thus, in this review we present the critical and recent antecedents regarding the mechanisms and cellular targets involved in the effects of TGF-β1 in the muscle, in pathological processes such as the inhibition of regeneration, fibrosis and atrophy. In addition, an update on the development of new strategies with therapeutic potential to inhibit the deleterious actions of TGF-β in skeletal muscle is discussed.

AB - Among the soluble factors that regulate skeletal muscle function, Transforming Growth Factor type Beta 1 (TGF-β1) is one of the most studied. This factor inhibits myogenesis and regeneration by regulating the activity and function of satellite cells (SCs). Indeed, TGF-β has a central role in muscle pathologies in which there is development of fibrosis and/or atrophy of skeletal muscle. Thus, in this review we present the critical and recent antecedents regarding the mechanisms and cellular targets involved in the effects of TGF-β1 in the muscle, in pathological processes such as the inhibition of regeneration, fibrosis and atrophy. In addition, an update on the development of new strategies with therapeutic potential to inhibit the deleterious actions of TGF-β in skeletal muscle is discussed.

KW - blocking antibodies

KW - dystrophy

KW - fibrosis

KW - Muscle atrophy

KW - renin angiotensin system

KW - therapy.

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U2 - 10.2174/1389203718666171117101916

DO - 10.2174/1389203718666171117101916

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JO - Current Protein and Peptide Science

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