Causas de muerte en pacientes con un injerto renal funcionante. ¿Han ocurrido cambios en las últimas décadas?

Jorge Vega, Christian Videla, Hernán Borja, Helmuth Goecke, Felipe Martínez, Pablo Betancour

Resultado de la investigación: Article

2 Citas (Scopus)

Resumen

Background: Death with a functioning graft(DWGF) is now one of the main causes of renal transplant (RTx) loss. Aim: To determine whether the causes of DWGF, characteristics of donors and recipients and complications of RTx have changed in the last two decades. Subjects and Methods: Cooperative study of a cohort of 418 kidney grafts performed between 1968 and 2010. Patients were divided into two groups according to whether their kidney transplants were performed between 1968 and 1992 (Group 1) or 1993 and 2010 (Group 2). Results: Sixty eight patients experienced DWGF. Infections were the leading cause of DWGF in both groups (38 and 41%, respectively), followed by cardiovascular diseases (24 and 23% respectively), gastrointestinal disorders (21 and 26% respectively) and cancer (17 and 10% respectively). There were no significant differences in causes of death between the two groups according to the time elapsed since the renal transplantation. In patients in Group 1, the interval between diagnosis of renal failure and dialysis (HD) and the interval between the start of HD and kidney transplantation were significantly lower than in Group 2. The former had also an increased number of acute rejections in the first five years of kidney transplantation (p < 0.001). In Group 2, patients more often received their kidneys from deceased donors, had previous kidney transplantation, higher rate of antibodies to a panel of lymphocytes and an increased incidence of cardiovascular disorders after five years of RTx. Conclusions: The proportion of graftloss due to DWGF has increased over the last 2 decades, but its causes have not changed significantly. Infections are the most common causes of DWGF followed by cardiovascular and digestive diseases.

Idioma originalSpanish
Páginas (desde-hasta)295-304
Número de páginas10
PublicaciónRevista Medica de Chile
Volumen140
N.º3
DOI
EstadoPublished - 1 mar 2012

Huella dactilar

Allografts
Cause of Death
Transplants
Kidney
Kidney Transplantation
Cardiovascular Diseases
Tissue Donors
Infection
Renal Insufficiency
Renal Dialysis
Cohort Studies
Lymphocytes
Antibodies
Incidence
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Citar esto

Vega, Jorge ; Videla, Christian ; Borja, Hernán ; Goecke, Helmuth ; Martínez, Felipe ; Betancour, Pablo. / Causas de muerte en pacientes con un injerto renal funcionante. ¿Han ocurrido cambios en las últimas décadas?. En: Revista Medica de Chile. 2012 ; Vol. 140, N.º 3. pp. 295-304.
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title = "Causas de muerte en pacientes con un injerto renal funcionante. ¿Han ocurrido cambios en las {\'u}ltimas d{\'e}cadas?",
abstract = "Background: Death with a functioning graft(DWGF) is now one of the main causes of renal transplant (RTx) loss. Aim: To determine whether the causes of DWGF, characteristics of donors and recipients and complications of RTx have changed in the last two decades. Subjects and Methods: Cooperative study of a cohort of 418 kidney grafts performed between 1968 and 2010. Patients were divided into two groups according to whether their kidney transplants were performed between 1968 and 1992 (Group 1) or 1993 and 2010 (Group 2). Results: Sixty eight patients experienced DWGF. Infections were the leading cause of DWGF in both groups (38 and 41{\%}, respectively), followed by cardiovascular diseases (24 and 23{\%} respectively), gastrointestinal disorders (21 and 26{\%} respectively) and cancer (17 and 10{\%} respectively). There were no significant differences in causes of death between the two groups according to the time elapsed since the renal transplantation. In patients in Group 1, the interval between diagnosis of renal failure and dialysis (HD) and the interval between the start of HD and kidney transplantation were significantly lower than in Group 2. The former had also an increased number of acute rejections in the first five years of kidney transplantation (p < 0.001). In Group 2, patients more often received their kidneys from deceased donors, had previous kidney transplantation, higher rate of antibodies to a panel of lymphocytes and an increased incidence of cardiovascular disorders after five years of RTx. Conclusions: The proportion of graftloss due to DWGF has increased over the last 2 decades, but its causes have not changed significantly. Infections are the most common causes of DWGF followed by cardiovascular and digestive diseases.",
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Causas de muerte en pacientes con un injerto renal funcionante. ¿Han ocurrido cambios en las últimas décadas? / Vega, Jorge; Videla, Christian; Borja, Hernán; Goecke, Helmuth; Martínez, Felipe; Betancour, Pablo.

En: Revista Medica de Chile, Vol. 140, N.º 3, 01.03.2012, p. 295-304.

Resultado de la investigación: Article

TY - JOUR

T1 - Causas de muerte en pacientes con un injerto renal funcionante. ¿Han ocurrido cambios en las últimas décadas?

AU - Vega, Jorge

AU - Videla, Christian

AU - Borja, Hernán

AU - Goecke, Helmuth

AU - Martínez, Felipe

AU - Betancour, Pablo

PY - 2012/3/1

Y1 - 2012/3/1

N2 - Background: Death with a functioning graft(DWGF) is now one of the main causes of renal transplant (RTx) loss. Aim: To determine whether the causes of DWGF, characteristics of donors and recipients and complications of RTx have changed in the last two decades. Subjects and Methods: Cooperative study of a cohort of 418 kidney grafts performed between 1968 and 2010. Patients were divided into two groups according to whether their kidney transplants were performed between 1968 and 1992 (Group 1) or 1993 and 2010 (Group 2). Results: Sixty eight patients experienced DWGF. Infections were the leading cause of DWGF in both groups (38 and 41%, respectively), followed by cardiovascular diseases (24 and 23% respectively), gastrointestinal disorders (21 and 26% respectively) and cancer (17 and 10% respectively). There were no significant differences in causes of death between the two groups according to the time elapsed since the renal transplantation. In patients in Group 1, the interval between diagnosis of renal failure and dialysis (HD) and the interval between the start of HD and kidney transplantation were significantly lower than in Group 2. The former had also an increased number of acute rejections in the first five years of kidney transplantation (p < 0.001). In Group 2, patients more often received their kidneys from deceased donors, had previous kidney transplantation, higher rate of antibodies to a panel of lymphocytes and an increased incidence of cardiovascular disorders after five years of RTx. Conclusions: The proportion of graftloss due to DWGF has increased over the last 2 decades, but its causes have not changed significantly. Infections are the most common causes of DWGF followed by cardiovascular and digestive diseases.

AB - Background: Death with a functioning graft(DWGF) is now one of the main causes of renal transplant (RTx) loss. Aim: To determine whether the causes of DWGF, characteristics of donors and recipients and complications of RTx have changed in the last two decades. Subjects and Methods: Cooperative study of a cohort of 418 kidney grafts performed between 1968 and 2010. Patients were divided into two groups according to whether their kidney transplants were performed between 1968 and 1992 (Group 1) or 1993 and 2010 (Group 2). Results: Sixty eight patients experienced DWGF. Infections were the leading cause of DWGF in both groups (38 and 41%, respectively), followed by cardiovascular diseases (24 and 23% respectively), gastrointestinal disorders (21 and 26% respectively) and cancer (17 and 10% respectively). There were no significant differences in causes of death between the two groups according to the time elapsed since the renal transplantation. In patients in Group 1, the interval between diagnosis of renal failure and dialysis (HD) and the interval between the start of HD and kidney transplantation were significantly lower than in Group 2. The former had also an increased number of acute rejections in the first five years of kidney transplantation (p < 0.001). In Group 2, patients more often received their kidneys from deceased donors, had previous kidney transplantation, higher rate of antibodies to a panel of lymphocytes and an increased incidence of cardiovascular disorders after five years of RTx. Conclusions: The proportion of graftloss due to DWGF has increased over the last 2 decades, but its causes have not changed significantly. Infections are the most common causes of DWGF followed by cardiovascular and digestive diseases.

KW - Immunosuppressive agents

KW - Kidney transplantation

KW - Morbidity

KW - Mortality

KW - Prognosis

KW - Treatment outcome

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U2 - 10.4067/S0034-98872012000300003

DO - 10.4067/S0034-98872012000300003

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JO - Revista Medica de Chile

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