Carbachol interactions with nonsteroidal anti-inflammatory drugs

H. F. Miranda, F. Sierralta, G. Pinardi

Resultado de la investigación: Article

3 Citas (Scopus)

Resumen

The inhibition of cyclooxygenase enzymes by nonsteroidal anti-inflammatory drugs (NSAIDs) does not completely explain the antinociceptive efficacy of these agents. It is known that cholinergic agonists are antinociceptive, and this study evaluates the interactions between carbachol and some NSAIDs. Antinociceptive activity was evaluated in mice by the acetic acid writhing test. Dose-response curves were constructed for NSAIDs and carbachol, administered either intraperitoncally (i.p.) or intrathecally (i.t.). The interactions of carbachol with NSAIDs were evaluated by isobolographic analysis after the simultaneous administration of fixed proportions of carbachol with each NSAID. All of the drugs were more potent after spinal than after systemic administration. The combinations of NSAIDs and carbachol administered i.p. were supra-additive; however, the i.t. combinations were only additive. Isobolographic analysis of the coadministration of NSAIDs and carbachol and the fact that atropine antagonized the synergistic effect suggest that carbachol may strongly modulate the antinociceptive activity of NSAIDs; thus, central cholinergic modulation would be an additional mechanism for the antinociceptive action of NSAIDs, unrelated to prostaglandin biosynthesis inhibition.

Idioma originalEnglish
Páginas (desde-hasta)1173-1179
Número de páginas7
PublicaciónCanadian Journal of Physiology and Pharmacology
Volumen80
N.º12
DOI
EstadoPublished - dic 2002

Huella dactilar

Carbachol
Anti-Inflammatory Agents
Pharmaceutical Preparations
Cholinergic Agonists
Prostaglandin-Endoperoxide Synthases
Atropine
Acetic Acid
Cholinergic Agents
Prostaglandins
Analgesics

ASJC Scopus subject areas

  • Medicine(all)
  • Physiology
  • Pharmacology
  • Physiology (medical)

Citar esto

Miranda, H. F. ; Sierralta, F. ; Pinardi, G. / Carbachol interactions with nonsteroidal anti-inflammatory drugs. En: Canadian Journal of Physiology and Pharmacology. 2002 ; Vol. 80, N.º 12. pp. 1173-1179.
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abstract = "The inhibition of cyclooxygenase enzymes by nonsteroidal anti-inflammatory drugs (NSAIDs) does not completely explain the antinociceptive efficacy of these agents. It is known that cholinergic agonists are antinociceptive, and this study evaluates the interactions between carbachol and some NSAIDs. Antinociceptive activity was evaluated in mice by the acetic acid writhing test. Dose-response curves were constructed for NSAIDs and carbachol, administered either intraperitoncally (i.p.) or intrathecally (i.t.). The interactions of carbachol with NSAIDs were evaluated by isobolographic analysis after the simultaneous administration of fixed proportions of carbachol with each NSAID. All of the drugs were more potent after spinal than after systemic administration. The combinations of NSAIDs and carbachol administered i.p. were supra-additive; however, the i.t. combinations were only additive. Isobolographic analysis of the coadministration of NSAIDs and carbachol and the fact that atropine antagonized the synergistic effect suggest that carbachol may strongly modulate the antinociceptive activity of NSAIDs; thus, central cholinergic modulation would be an additional mechanism for the antinociceptive action of NSAIDs, unrelated to prostaglandin biosynthesis inhibition.",
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Carbachol interactions with nonsteroidal anti-inflammatory drugs. / Miranda, H. F.; Sierralta, F.; Pinardi, G.

En: Canadian Journal of Physiology and Pharmacology, Vol. 80, N.º 12, 12.2002, p. 1173-1179.

Resultado de la investigación: Article

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AU - Pinardi, G.

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