Carbachol interactions with nonsteroidal anti-inflammatory drugs

H. F. Miranda, F. Sierralta, G. Pinardi

Resultado de la investigación: Contribución a una revistaArtículo

3 Citas (Scopus)


The inhibition of cyclooxygenase enzymes by nonsteroidal anti-inflammatory drugs (NSAIDs) does not completely explain the antinociceptive efficacy of these agents. It is known that cholinergic agonists are antinociceptive, and this study evaluates the interactions between carbachol and some NSAIDs. Antinociceptive activity was evaluated in mice by the acetic acid writhing test. Dose-response curves were constructed for NSAIDs and carbachol, administered either intraperitoncally (i.p.) or intrathecally (i.t.). The interactions of carbachol with NSAIDs were evaluated by isobolographic analysis after the simultaneous administration of fixed proportions of carbachol with each NSAID. All of the drugs were more potent after spinal than after systemic administration. The combinations of NSAIDs and carbachol administered i.p. were supra-additive; however, the i.t. combinations were only additive. Isobolographic analysis of the coadministration of NSAIDs and carbachol and the fact that atropine antagonized the synergistic effect suggest that carbachol may strongly modulate the antinociceptive activity of NSAIDs; thus, central cholinergic modulation would be an additional mechanism for the antinociceptive action of NSAIDs, unrelated to prostaglandin biosynthesis inhibition.

Idioma originalInglés
Páginas (desde-hasta)1173-1179
Número de páginas7
PublicaciónCanadian Journal of Physiology and Pharmacology
EstadoPublicada - dic 2002

Áreas temáticas de ASJC Scopus

  • Medicina (todo)
  • Fisiología
  • Farmacología
  • Fisiología (médica)

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