Bromodomains in living cells participate in deciphering the histone code

Alejandra Loyola, Genevieve Almouzni

Resultado de la investigación: Contribución a una revistaArtículo de revisión

29 Citas (Scopus)

Resumen

The bromodomain, a module of ∼110 amino acids, is found in several chromatin-associated proteins, including histone acetyltransferases and chromatin-remodeling factors, and can bind to acetylated lysines. Such post-translational modifications occur mainly in the N-terminal tail of the histone proteins and, in combination with other modifications, are thought to participate in defining a histone code. Recent findings provide a model for how bromodomain-containing proteins participate in the recognition of acetylated histones.

Idioma originalInglés
Páginas (desde-hasta)279-281
Número de páginas3
PublicaciónTrends in Cell Biology
Volumen14
N.º6
DOI
EstadoPublicada - 1 jun 2004

Áreas temáticas de ASJC Scopus

  • Biología celular

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